3046451-91-3
Chemical Structure
Antiparasitic agent-15
- CAS No.: 3046451-91-3
- Formula:C17H16N4OS
- Molecular Weight:324.40
IUPAC Name: (E)-5,5-dimethyl-3-phenyl-2-(((E)-pyridin-2-ylmethylene)hydrazono)thiazolidin-4-one
InChIKey: KQSJQJNXYXDHPK-YEFHWUCQSA-N
SMILES: CC1(S/C(N(C1=O)C2=CC=CC=C2)=N/N=C/C3=CC=CC=N3)C
Biological Activity: Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes[1].
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Antiparasitic agent-15 | Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes. | |||||||||||||||||||||
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Keywords
