1 Result for "

3484-65-9

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "3484-65-9" in MCE Product Catalog:

Aspergillomarasmine A
Aspergillomarasmine A
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Cat. No.: HY-129200
CAS No.: 3484-65-9
Category:  

Human Gut Microbiota Metabolites Endogenous metabolite

Target:  

Endogenous Metabolite Bacterial Beta-lactamase

Aspergillomarasmine A is a fungal secondary metabolite derived from natural amino acids, with inhibitory activity against metallo-β-lactamases. Aspergillomarasmine A selectively inhibits the metallo-β-lactamases NDM-1 and VIM-2, but shows weak inhibitory activity against IMP-7. Aspergillomarasmine A exhibits metal ion selectivity, which enables it to capture spontaneously dissociated Zn 2+ from NDM-1, inducing the monozincation and inactivation of the enzyme; the inactivated metallo-β-lactamase undergoes protein degradation in the bacterial periplasm, thereby restoring the bacteriostatic efficacy of carbapenem antibiotics. Aspergillomarasmine A can be used in studies related to bacterial infections .
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