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75644-95-0

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "75644-95-0" in MCE Product Catalog:

[Trp11]-Neurotensin
[Trp11]-Neurotensin
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Cat. No.: HY-P3057A
CAS No.: 75644-95-0
Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease

[Trp11]-Neurotensin is a neurotensin analog and neurotensin receptor agonist. The Tyr11 residue of neurotensin is replaced by L-Trp. [Trp11]-Neurotensin competes for neurotensin receptor binding sites, with an IC50 of 4.3 nM in rat brain synaptic membranes, and activates neurotensin receptor-mediated smooth muscle responses, with an EC50 of 1.7 nM in rat ileum, exhibiting significant species-dependent differences in receptor recognition. [Trp11]-Neurotensin can be used in studies related to neurotensin receptor pharmacology, gastrointestinal smooth muscle, and species-dependent receptor recognition .
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