[Trp11]-Neurotensin

[Trp11]-Neurotensin is a neurotensin analog and neurotensin receptor agonist. The Tyr11 residue of neurotensin is replaced by L-Trp. [Trp11]-Neurotensin competes for neurotensin receptor binding sites, with an IC₅₀ of 4.3 nM in rat brain synaptic membranes, and activates neurotensin receptor-mediated smooth muscle responses, with an EC₅₀ of 1.7 nM in rat ileum, exhibiting significant species-dependent differences in receptor recognition. [Trp11]-Neurotensin can be used in studies related to neurotensin receptor pharmacology, gastrointestinal smooth muscle, and species-dependent receptor recognition.

• Custom Peptide Synthesis