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83182-58-5

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8α-Tigloyloxyhirsutinolide 13-O-acetate
8α-Tigloyloxyhirsutinolide 13-O-acetate
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Cat. No.: HY-138071
CAS No.: 83182-58-5
Synonyms: 8αTGH
Category:  

Terpenoids Sesquiterpenes Plants Compositae Dalbergia frutescens (Vell.) Britton

Target:  

STAT Pyroptosis Apoptosis Reactive Oxygen Species (ROS) c-Myc Bcl-2 Family TrxR

8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo .
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