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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
91 Results for "
ADH
" in MedChemExpress (MCE) Product Catalog:
Products (91)
91 Results for "ADH" in MCE Product Catalog:
12
ADH-1 (Exherin) is a cyclic pentapeptide N-cadherin antagonist. ADH-1 binds to N-cadherin EC1-2 as an HAV mimetic, competitively blocks homophilic trans interactions, forms a stable protein-drug complex, and induces conformational rearrangement. ADH-1 targets tumor microvasculature, causing vascular injury and apoptosis. ADH-1 inhibits tumor growth and metastasis in mouse tumor models. ADH-1 can be used in cancer-related research .
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12 Cited Publications
Synonyms: Exherin TFA
ADH-1 TFA (Exherin TFA) is a cyclic pentapeptide N-cadherin antagonist. ADH-1 TFA binds to N-cadherin EC1-2 as an HAV mimetic, competitively blocks homophilic trans interactions, forms a stable protein-drug complex, and induces conformational rearrangement. ADH-1 TFA targets tumor microvasculature, causing vascular injury and apoptosis. ADH-1 TFA inhibits tumor growth and metastasis in mouse tumor models. ADH-1 TFA can be used in cancer-related research .
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7 Cited Publications
Cat. No.: HY-B1811
CAS No.: 11000-17-2
Synonyms: Arginine vasopressin; Antidiuretic hormone
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3 Cited Publications
Synonyms: (Z)-LeukADHerin-1 choline
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ADH-503 ((Z)-Leukadherin-1 choline) is an orally active and allosteric CD11b agonist. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses .
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Triterpenes Plant Taraxacum mongolicum Hand.-Mazz. Extract Terpenoids Crassulaceae Extract Sedum sarmentosum Bunge Extract Compositae/Asteraceae Extract Disease Research Fields Inflammation/Immunology
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Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively.
Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family.
ADH and ALDH are enzymes that work together to metabolize alcohol .
ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases .
Cat. No.: HY-164690A
CAS No.: 2600354-60-5
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Nicotinamide-guanine dinucleotide sodium, a NAD sodium (HY-B0445A) analog, is an oxidized forms of nicotinamide guanine dinucleotide. Nicotinamide-guanine dinucleotide sodium serves as coenzymes for alcohol dehydrogenase (ADH) in vitro .
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Alcohol dehydrogenase, yeast is an alcohol dehydrogenase derived from yeast. Alcohol dehydrogenase is a class of oxidoreductases that catalyze the reversible oxidation of alcohols to aldehydes or ketones, with the concomitant reduction of NAD + or NADP +. Alcohol dehydrogenase represents a large family of enzymes, which can be subdivided into at least three distinct enzyme superfamilies: medium-chain dehydrogenase/reductase (MDR), short-chain dehydrogenase/reductase, and iron-activated alcohol dehydrogenase (ADH) .
Cat. No.: HY-145785
CAS No.: 2227429-65-2
ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].
Cat. No.: HY-RS00370
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ADH5 Human Pre-designed siRNA Set A contains three designed siRNAs for ADH5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P0049A
CAS No.: 75499-44-4
Synonyms: Arg8-vasopressin diacetate; AVP diacetate; ADH
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Trimethylacetaldehyde (Pivalic aldehyde; Pivalaldehyde) is an inhibitor of E. coli betaine aldehyde dehydrogenase (ALDH) with a Ki of 4.5 mM. Trimethylacetaldehyde serves as a substrate for Drosophila melanogaster alcohol dehydrogenase (AdhS), undergoing oxidation and disproportionation reactions with the release of NADH, and also forms an inactive binary enzyme-aldehyde complex via a compulsory ordered reaction mechanism .
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Adipic acid dihydrazide (Adipodihydrazide) is a crosslinking agent that reacts with aldehyde groups to form pH-sensitive hydrazone bonds. Adipic acid dihydrazide can be used to prepare oxi‑HA/ADH8 injectable hydrogels for nucleus pulposus regeneration and can also be used to construct Paclitaxel (HY-B0015)-loaded nanoformulations. Adipic acid dihydrazide can serve as an intermediate for organic synthesis-related research .
Cat. No.: HY-D0200S
CAS No.: 1202865-37-9
Synonyms: Adipodihydrazide-d8
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Adipic acid dihydrazide-d8 (Adipodihydrazide-d8) is the deuterated-labeled Adipic acid dihydrazide (HY-D0200). Adipic acid dihydrazide (Adipodihydrazide) is a crosslinking agent that reacts with aldehyde groups to form pH-sensitive hydrazone bonds. Adipic acid dihydrazide can be used to prepare oxi‑HA/ADH8 injectable hydrogels for nucleus pulposus regeneration and can also be used to construct Paclitaxel (HY-B0015)-loaded nanoformulations. Adipic acid dihydrazide can serve as an intermediate for organic synthesis-related research .
Cat. No.: HY-122297A
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Cat. No.: HY-33914
CAS No.: 25222-43-9
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Methoxyflurane (DA-759) is a volatile anesthetic and nephrotoxic agent. Methoxyflurane is metabolized by CYP450 to inorganic fluoride, dichloroacetic acid, and oxalate-related products, which accumulate in the renal tubules and inhibit Na, K-ATPase and Na-K-2Cl transport, leading to proximal tubular mitochondrial injury, ADH-resistant polyuria, and renal dysfunction. Methoxyflurane enhances chloride currents of GABAA α2β1 and glycine α1 receptors, positively modulates 5-HT3 receptors, and inhibits nicotinic acetylcholine receptors and voltage-gated calcium channels, reducing catecholamine secretion. Methoxyflurane is used in research on neurological diseases and kidney diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
