2227429-65-2
Chemical Structure
ADH-6
- CAS No.: 2227429-65-2
- Formula:C29H36N8O9
- Molecular Weight:640.64
IUPAC Name: methyl 6-(3-aminopropoxy)-5-(6-(3-aminopropoxy)-5-(6-butoxy-5-nitropicolinamido)picolinamido)picolinate
InChIKey: KDVRSKDEDDWURT-UHFFFAOYSA-N
SMILES: O=C(C1=NC(OCCCN)=C(NC(C2=NC(OCCCN)=C(NC(C3=NC(OCCCC)=C([N+]([O-])=O)C=C3)=O)C=C2)=O)C=C1)OC
Biological Activity: ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].
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ADH-6 | ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases. | |||||||||||||||||||||
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