25222-43-9
25222-43-9
Chemical Structure
4-Hydroxymethylpyrazole
- CAS 番号: 25222-43-9
- Formula:C4H6N2O
- Molecular Weight:98.11
IUPAC Name: (1H-pyrazol-4-yl)methanol
InChIKey: JRMKJOOJKCAEJK-UHFFFAOYSA-N
SMILES: OCC1=CNN=C1
Biological Activity: 4-Hydroxymethylpyrazole is the major phase I oxidative metabolite of 4-Methylpyrazole (HY-B0876) in rats and can be further oxidized to form 4-Carboxypyrazole (HY-W002065). 4-Hydroxymethylpyrazole acts as a substrate and competitive inhibitor of alcohol dehydrogenase (ADH). 4-Hydroxymethylpyrazole can be used in metabolism-related research[1][2].
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4-Hydroxymethylpyrazole | 99.74% | 4-Hydroxymethylpyrazole is the major phase I oxidative metabolite of 4-Methylpyrazole (HY-B0876) in rats and can be further oxidized to form 4-Carboxypyrazole (HY-W002065). 4-Hydroxymethylpyrazole acts as a substrate and competitive inhibitor of alcohol dehydrogenase (ADH). 4-Hydroxymethylpyrazole can be used in metabolism-related research. | ||||||||||||||||||||
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4-Hydroxymethylpyrazole (Standard) | ≥98% | 4-Hydroxymethylpyrazole (Standard) is the analytical standard of 4-Hydroxymethylpyrazole (HY-33914). This product is intended for research and analytical applications. 4-Hydroxymethylpyrazole is the major phase I oxidative metabolite of 4-Methylpyrazole (HY-B0876) in rats and can be further oxidized to form 4-Carboxypyrazole (HY-W002065). 4-Hydroxymethylpyrazole acts as a substrate and competitive inhibitor of alcohol dehydrogenase (ADH). 4-Hydroxymethylpyrazole can be used in metabolism-related research. | ||||||||||||||||||||
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References
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[1]. Pietruszko R. Human liver alcohol dehydrogenase—inhibition of methanol activity by pyrazole, 4-methylpyrazole, 4-hydroxymethylpyrazole and 4-carboxypyrazole. Biochemical Pharmacology, 1975, 24: 1603-1607.
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[2]. Blomstrand R. Studies on the metabolism of LADH-inhibitor 4-methylpyrazole in the rat. Life Sciences, 1973, 13(2): 107-112.
