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Results for "

APN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (5) Akt (1) Aminopeptidase (18) Androgen Receptor (2) Antibiotic (7) Apoptosis (2) Bacterial (8) Biochemical Assay Reagents (1) COX (1) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Drug Derivative (1) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (1) Enteropeptidase (2) ERK (2) Farnesyl Transferase (1) Fluorescent Dye (2) HDAC (1) IKK (1) Isotope-Labeled Compounds (2) Liposome (1) mTOR (3) MyD88 (1) Neprilysin (2) NF-κB (1) NO Synthase (1) NOD-like Receptor (NLR) (1) Opioid Receptor (2) p38 MAPK (1) PERK (1) PPAR (1) PROTAC Linkers (5) Reference Standards (2) Small Interfering RNA (siRNA) (4) Tau Protein (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (28) Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (5)
Click Chemistry:	ADC Synthesis (4) DBCO (1) PROTAC Synthesis (2) Azide (2) BCN (1) Tetrazine (2) Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (1) siRNAs (4)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0134

Bestatin 10+ Cited Publications Ubenimex	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-B0134A

Bestatin hydrochloride 10+ Cited Publications Ubenimex hydrochloride	Antibiotic Bacterial Aminopeptidase	Infection Cancer
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-P9933

Dinutuximab APN-311; Ch14.18; MAb-14.18	Apoptosis PERK mTOR	Cancer
Dinutuximab (APN-311) is a chimeric human-mouse anti-GD2 monoclonal antibody. Dinutuximab can bind to GD2 on the cell surface, triggering antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, and promoting tumor regression. Dinutuximab can inhibit the growth, invasion, and migration and induce apoptosis of tumor cells. Dinutuximab can be used in the research of tumors such as neuroblastoma and breast cancer .

HY-137557

Florzolotau APN1607; PM-PBB3	Tau Protein	Neurological Disease
Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used for the detection of Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-sheet of paired helical filaments (PHFs) and straight filaments (SFs) of tau protein, as well as in the C-shaped cavity of SFs. In addition, APN-1607 binds to intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART) and posterior cortical atrophy (PCA). Florzolotau shows promise for PET imaging studies of neurological disorders, particularly tau proteinopathies .

HY-E70199

Aminopeptidase N (rat) APN/CD13	Aminopeptidase	Cardiovascular Disease
Aminopeptidase N (rat) (APN/CD13) is a Zn ²⁺-dependent membrane-bound exopeptidase that preferentially degrades proteins and peptides with N-terminal neutral amino acids. Aminopeptidase N (rat) is inhibited by angiotensin IV and participates in the regulation of angiotensin IV half-life in the rat striatum .

HY-170704

DSPE-PEG2000-TCO	Liposome	Metabolic Disease Cancer
DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and *APN*-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis .

HY-B0134AS

Bestatin-d7 hydrochloride Ubenimex-d7 hydrochloride	Isotope-Labeled Compounds Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-P1043

NGR peptide 1 Publications Verification	Aminopeptidase	Cancer
NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging .

HY-163549

APN-PEG5-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
APN-PEG5-VC-PAB-MMAE is a drug-linker conjugate part of INA03 (a transferrin-competitive antibody-drug conjugate against CD71) .

HY-N2150

Psammaplin A	HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial Aminopeptidase Farnesyl Transferase PPAR Apoptosis	Infection Inflammation/Immunology Cancer
Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC₅₀: 45 nM), DNA methyltransferases (IC₅₀: 18.6 nM) and aminopeptidase N (APN) (IC₅₀: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis .

HY-140841

APN-C3-PEG4-azide	PROTAC Linkers	Cancer
APN-C3-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . APN-C3-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P1043A

NGR peptide Trifluoroacetate 1 Publications Verification	Aminopeptidase	Cancer
NGR peptide Trifluoroacetatecontaining the Asn-Gly-Arg (NGR) motif. NGR peptide Trifluoroacetate binds to APN/CD13. NGR peptide Trifluoroacetate is directly conjugated to imaging agents that can be used for tumor imaging .

HY-136044

APN-PEG4-BCN	ADC Linker	Cancer
APN-PEG4-BCN is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-136045

APN-PEG4-tetrazine	ADC Linker	Cancer
APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-145244

APN/AKT-IN-1	Akt	Cancer
APN/AKT-IN-1 is a potent and dual inhibitor of APN and AKT with IC₅₀s of 0.21 and 0.27 μM, respectively. APN/AKT-IN-1 can effectively inhibit the phosphorylation of GSK3β, the intracellular substrate of AKT .

HY-B0134R

Bestatin (Standard) Ubenimex (Standard)	Reference Standards Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-P11642A

Sialorphin TFA	Enteropeptidase Aminopeptidase Opioid Receptor ERK mTOR Androgen Receptor	Inflammation/Immunology
Sialorphin TFA is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin TFA blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin TFA regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin TFA exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin TFA also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin TFA is also a copper (II) ion-binding ligand. Sialorphin TFA has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-139859

APN-PEG36-tetrazine	ADC Linker	Cancer
APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG36-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-140348

APN-NH2	PROTAC Linkers	Cancer
APN- NH2 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . APN- NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-136030

APN-PEG4-PFP	PROTAC Linkers	Cancer
APN-PEG4-PFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . APN-PEG4-PFP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-136049

APN-PEG4-DBCO	ADC Linker	Cancer
APN-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-130939

APN-PEG4-Amine hydrochloride	ADC Linker	Cancer
APN-PEG4-Amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-Amine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-116306

Probestin	Aminopeptidase	Others
Probestin is a potent aminopeptidase N (APN) inhibitor produced by Streptomyces cyanogens MH663-2F6 .

HY-W123012

APN-Azide 3-(4-Azidophenyl)propiolonitrile	Fluorescent Dye
APN-Azide (3-(4-Azidophenyl)propiolonitrile) is a codon-active compound that can achieve specific labeling of target molecules in biological systems through its unique chemical structure. APN-Azide can be used for bioimaging and the development of molecular probes to study biological processes within cells.

HY-116025

APN-C3-PEG4-alkyne	PROTAC Linkers	Cancer
APN-C3-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . APN-C3-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-140347

APN-C3-NH-Boc tert-Butyl 3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylcarbamate	PROTAC Linkers	Cancer
APN-C3-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . APN-C3-NH-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-RS18648

Anpep Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Anpep Mouse Pre-designed siRNA Set A contains three designed siRNAs for Anpep gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Anpep Mouse Pre-designed siRNA Set A Anpep Mouse Pre-designed siRNA Set A

HY-RS25133

Anpep Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Anpep Rat Pre-designed siRNA Set A contains three designed siRNAs for Anpep gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Anpep Rat Pre-designed siRNA Set A Anpep Rat Pre-designed siRNA Set A

HY-170962

SDUY817	Neprilysin Aminopeptidase	Neurological Disease
SDUY817 is a dual *APN/NEP* inhibitor, with IC₅₀ values of 0.29 μM for *APN* and 7.4 μM for NEP. SDUY817 exerts analgesic effects in a concentration- and time-dependent manner, and can be used for research in the field of neuropathic pain disorders .

HY-RS00754

ANPEP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ANPEP Human Pre-designed siRNA Set A contains three designed siRNAs for ANPEP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ANPEP Human Pre-designed siRNA Set A ANPEP Human Pre-designed siRNA Set A

HY-B0134B

Bestatin trifluoroacetate Ubenimex trifluoroacetate	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin trifluoroacetate is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-172879

Aminopeptidase N inhibitor 2	Aminopeptidase	Cancer
Aminopeptidase N inhibitor 2 (Compound 2k) is an *APN* inhibitor (IC₅₀: 4.3 μM) and has antitumor activity.

HY-170961

SDUY816	Aminopeptidase Neprilysin	Neurological Disease
SDUY816 is an oral active dual *APN/NEP* inhibitor, with IC₅₀ values of 0.68 μM for *APN* and 6.9 μM for NEP. SDUY816 exhibits analgesic effects and demonstrates good safety and pharmacokinetic profiles, with an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral administration, 10 mg/kg). SDUY816 has potential applications in the research of neuropathic pain disorders .

HY-B0134AR

Bestatin hydrochloride (Standard) Ubenimex hydrochloride (Standard)	Reference Standards Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin (hydrochloride) (Standard) is the analytical standard of Bestatin (hydrochloride). This product is intended for research and analytical applications. Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-B0134S1

Bestatin-d10 Ubenimex-d₁₀	Isotope-Labeled Compounds Bacterial Antibiotic Aminopeptidase	Infection Cancer
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-RS17562

Adipoq Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Adipoq Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adipoq gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adipoq Mouse Pre-designed siRNA Set A Adipoq Mouse Pre-designed siRNA Set A

HY-D2973

YH-APN	Fluorescent Dye	Others
YH-APN is a high-performance APN activated near-infrared fluorescent probe. YH-APN has high sensitivity, high selectivity, fast response, and can achieve extremely high tumor/normal tissue signal-to-noise ratio through in situ spraying. YH-APN can specifically distinguish cancer cells with high expression of APN from normal cells and monitor the migration of cancer cells .

HY-W190925

APN-C3-biotin	Biochemical Assay Reagents	Others
APN-C3-biotin is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and Biotin. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.

HY-137557A

(E/Z)-Florzolotau (E/Z)-APN1607; (E/Z)-PM-PBB3	Tau Protein	Neurological Disease
(E/Z)-Florzolotau ((E/Z)-APN1607) is a mixed configuration or unspecified configuration of Florzolotau (HY-137557). Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used for the detection of Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-sheet of paired helical filaments (PHFs) and straight filaments (SFs) of tau protein, as well as in the C-shaped cavity of SFs. In addition, APN-1607 binds to intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART) and posterior cortical atrophy (PCA). Florzolotau shows promise for PET imaging studies of neurological disorders, particularly tau proteinopathies .

HY-N19847

LYRM03	Drug Derivative Aminopeptidase Endogenous Metabolite Toll-like Receptor (TLR) MyD88 NOD-like Receptor (NLR) NF-κB p38 MAPK IKK NO Synthase COX	Inflammation/Immunology Cancer
LYRM03 is a derivative of Ubenimex (HY-B0134) and a Aminopeptidase N inhibitor. LYRM03 is isolated from Streptomyces HCCB10043. LYRM03 inhibits TLR4, MyD88, NLRP3, ASC, NF-κB and p38 MAPK, stabilizes IκB, and suppresses LPS-induced expression of iNOS and COX-2. LYRM03 reduces the levels of inflammatory cytokines and oxidative stress markers, and alleviates pulmonary edema. LYRM03 exhibits anticancer activity against breast cancer. LYRM03 has anti-inflammatory activity. LYRM03 can be used in the research of acute lung injury and breast cancer .

HY-P11642

Sialorphin	ERK Androgen Receptor Opioid Receptor Enteropeptidase mTOR Aminopeptidase	Neurological Disease Inflammation/Immunology Cancer
Sialorphin is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin is also a copper (II) ion-binding ligand. Sialorphin has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

YH-APN	Fluorescent Dye
YH-APN is a high-performance APN activated near-infrared fluorescent probe. YH-APN has high sensitivity, high selectivity, fast response, and can achieve extremely high tumor/normal tissue signal-to-noise ratio through in situ spraying. YH-APN can specifically distinguish cancer cells with high expression of APN from normal cells and monitor the migration of cancer cells .

Cat. No.	Product Name	Target	Research Area