2854340-31-9
2854340-31-9
Chemical Structure
APN/AKT-IN-1
- CAS No.: 2854340-31-9
- Formula:C18H27N7O3
- Molecular Weight:389.45
IUPAC Name: (R)-4-amino-N-(1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
InChIKey: MKBQAJXAABAJSL-CYBMUJFWSA-N
SMILES: NC1(C(N[C@H](CC(C)C)C(NO)=O)=O)CCN(CC1)C2=NC=NC3=C2C=CN3
Biological Activity: APN/AKT-IN-1 is a potent and dual inhibitor of APN and AKT with IC50s of 0.21 and 0.27 μM, respectively. APN/AKT-IN-1 can effectively inhibit the phosphorylation of GSK3β, the intracellular substrate of AKT[1].
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APN/AKT-IN-1 | APN/AKT-IN-1 is a potent and dual inhibitor of APN and AKT with IC50s of 0.21 and 0.27 μM, respectively. APN/AKT-IN-1 can effectively inhibit the phosphorylation of GSK3β, the intracellular substrate of AKT. | |||||||||||||||||||||
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References
Keywords
