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Results for "

AT2

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

2

Fluorescent Dye

3

Peptides

2

Natural
Products

4

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100113
    Buloxibutid
    5 Publications Verification

    AT2 receptor agonist C21

    		 Angiotensin Receptor p38 MAPK TGF-beta/Smad TGF-β Receptor MMP Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Buloxibutid (AT2 receptor agonist C21) is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis [2] .
    Buloxibutid
  • HY-12405
    CGP-42112
    2 Publications Verification

    CGP42112A

    		 Angiotensin Receptor Cardiovascular Disease Neurological Disease Endocrinology
    CGP-42112 (CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist .
    CGP-42112
  • HY-D1296
    Green DND-26
    2 Publications Verification

    		 Fluorescent Dye Others
    Green DND-26 is a green fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 504/511 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and generally gather on spherical organelles. Green DND-26 is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes .
    Green DND-26
  • HY-10259A
    PD 123319 ditrifluoroacetate
    Maximum Cited Publications
    11 Publications Verification

    		 Angiotensin Receptor Cardiovascular Disease Endocrinology
    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
    PD 123319 ditrifluoroacetate
  • HY-P0080
    Novokinin

    		Angiotensin Receptor Metabolic Disease
    Novokinin is a peptide agonist of the angiotensin AT2 receptor .
    Novokinin
  • HY-121767
    PD 123177

    		Angiotensin Receptor Cardiovascular Disease
    PD 123177 is a nonpeptide antagonist specific for angiotensin II (AII) subtype AT2 receptor in mammalian systems .
    PD 123177
  • HY-145425
    PAIR2

    		IRE1 Apoptosis FGFR Inflammation/Immunology
    PAIR2 is a highly selective inhibitor targeting the kinase domain of human IRE1α, with a Ki value of 8.8 nM against human IRE1α. PAIR2 fully occupies the ATP-binding site of the IRE1α kinase domain, partially antagonizes the ribonuclease activity of IRE1α, specifically inhibits regulated IRE1α-dependent decay (RIDD) and its mediated substrate cleavage, while preserving the splicing function of Xbp1 mRNA. PAIR2 also promotes the differentiation of B cells into plasma cells, blocks IRE1α-induced cell apoptosis, and restores the expression of Fgfr2 mRNA in AT2 cells. PAIR2 effectively reaches a steady-state concentration in the lung tissues of Mus musculus, and serves as an important tool for investigating the function of the IRE1α signaling pathway in diseases such as pulmonary fibrosis [2].
    PAIR2
  • HY-112824
    L-162313

    		Angiotensin Receptor Cardiovascular Disease
    L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC50 values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth .
    L-162313
  • HY-10259
    PD 123319

    (S)-(+)-PD 123319

    		 Angiotensin Receptor Cardiovascular Disease Endocrinology
    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
    PD 123319
  • HY-114285
    L-161638

    		Angiotensin Receptor Cardiovascular Disease
    L-161638 is a potent, selective and orally active AT2 receptor antagonist. L-161638 can be used for the research of cardiovascular disease, such as hypertension .
    L-161638
  • HY-162125
    AT2 receptor ligand-1

    		Angiotensin Receptor Cardiovascular Disease
    AT2 receptor ligand-1(compound 14) is a potent angiotensin AT2 receptor ligand with the Ki 4.9 nM. AT2 receptor ligand-1 shows high stability in microsomes of the sulfonamide ligands .
    AT2 receptor ligand-1
  • HY-108120
    L-162537

    		Angiotensin Receptor Cardiovascular Disease
    L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC50=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension .
    L-162537
  • HY-146410
    AT2R antagonist 1

    		Angiotensin Receptor Others
    AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes .
    AT2R antagonist 1
  • HY-P11389
    (Sar1,Gly8)-Angiotensin II

    		Angiotensin Receptor Neurological Disease
    (Sar1,Gly8)-Angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist (Ki: 52 nM for AT2 receptor in rat adrenal). (Sar1,Gly8)-Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II .
    (Sar1,Gly8)-Angiotensin II
  • HY-100113A
    Buloxibutid hydrochloride

    AT2 receptor agonist C21 hydrochloride

    		 Angiotensin Receptor p38 MAPK TGF-β Receptor TGF-beta/Smad MMP Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Buloxibutid (AT2 receptor agonist C21) hydrochloride is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid hydrochloride exerts vasodilatory, anti-inflammatory, antifibrotic (promoting the expression of collagenase MMP-13) and tissue repair effects mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway and inflammatory NF-κB pathway. Buloxibutid hydrochloride can be used in research related to idiopathic pulmonary fibrosis, hypertension, systemic sclerosis and other conditions [2] .
    Buloxibutid hydrochloride
  • HY-100113R
    Buloxibutid (Standard)

    AT2 receptor agonist C21 (Standard)

    		 Angiotensin Receptor Reference Standards p38 MAPK TGF-beta/Smad TGF-β Receptor MMP Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Buloxibutid (AT2 receptor agonist C21) (Standard) is the analytical standard of Buloxibutid (HY-100113). This product is intended for research and analytical applications. Buloxibutid is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis.
    Buloxibutid (Standard)
  • HY-114284
    L-163958

    		Angiotensin Receptor Cardiovascular Disease
    L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases .
    L-163958
  • HY-P0080A
    Novokinin TFA

    		Angiotensin Receptor Metabolic Disease
    Novokinin TFA is a peptide agonist of the angiotensin AT2 receptor .
    Novokinin TFA
  • HY-19202
    rac-Olodanrigan

    rac-EMA401; rac-PD-126055; EMA400

    		 Angiotensin Receptor Neurological Disease
    rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve .
    rac-Olodanrigan
  • HY-N14207
    Cytosporin C

    		Angiotensin Receptor Others
    Cytosporin C is a hexahydrobenzopyran derivative and an angiotensin II receptor inhibitor. Cytosporin C has relatively strong inhibitory activity against AT2, with an IC50 of 30-40 μM .
    Cytosporin C
  • HY-N14205
    Cytosporin A

    		Angiotensin Receptor Others
    Cytosporin A is a hexahydrobenzopyran derivative and an angiotensin II receptor antagonist. Cytosporin A has IC50 values of 25-30 μM and 1.5-3 μM for AT1 and AT2, respectively .
    Cytosporin A
  • HY-120238
    RG 13647

    		Angiotensin Receptor Cardiovascular Disease
    RG 13647 is an AT2-selective ligand. RG 13647 is an analog of PD 123177 (HY-121767). RG 13647 shows weak activity in competing for [125I]angiotensin II binding with an IC50 value of 100 μM. RG 13647 can be used for research of cardiovascular disease .
    RG 13647
  • HY-146027
    Androgen receptor antagonist 4

    		Androgen Receptor Cancer
    Androgen receptor antagonist 4 (Compound AT2) is an androgen receptor (AR) antagonist with an IC50 of 0.15 μM. Androgen receptor antagonist 4 efficiently antagonizes AR transcriptional activity, suppresses downstream target gene of AR, and blocks the DHT-induced AR nuclear translocation. Androgen receptor antagonist 4 shows anticancer activities .
    Androgen receptor antagonist 4
  • HY-RS00469
    AGTR2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    AGTR2 Human Pre-designed siRNA Set A contains three designed siRNAs for AGTR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AGTR2 Human Pre-designed siRNA Set A
    AGTR2 Human Pre-designed siRNA Set A
  • HY-170687
    AT2R-IN-1

    		Angiotensin Receptor Neurological Disease
    AT2R-IN-1 (A-174) is a AT2R inhibitor, used in the research of neuropathic pain .
    AT2R-IN-1
  • HY-162998
    AT2R antagonist 2

    		Angiotensin Receptor Cancer
    AT2R antagonist 2 (compound I-16) is an orally active AT2R antagonist .
    AT2R antagonist 2
  • HY-180401
    DMP 811

    		Angiotensin Receptor Cardiovascular Disease
    DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC50 = 6 nM) over AT2 (IC50 >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension [2] .
    DMP 811
  • HY-10259AR
    PD 123319 ditrifluoroacetate (Standard)

    		Reference Standards Angiotensin Receptor Cardiovascular Disease Endocrinology
    PD 123319 ditrifluoroacetate (Standard) is the analytical standard of PD 123319 ditrifluoroacetate (HY-10259A). This product is intended for research and analytical applications. PD 123319 ditrifluoroacetate is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
    PD 123319 ditrifluoroacetate (Standard)
  • HY-114282
    L-163007

    		Angiotensin Receptor Cardiovascular Disease
    L-163007 is an orally active AT1/2 receptor antagonist. L-163007 can be used for the research of cardiovascular disease, such as hypertension .
    L-163007
  • HY-DY1082
    Green DND-26 (solution)

    		Fluorescent Dye Others
    Green DND-26 (solution) is a green fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 504/511 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and generally gather on spherical organelles. Green DND-26 is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes .
    Solvent and concentration: DMSO: 2 mM
    Green DND-26 (solution)
  • HY-181439
    SNX3-IN-1

    		Wnt β-catenin Inflammation/Immunology
    SNX3-IN-1 is a sorting nexin 3 (SNX3) inhibitor. SNX3-IN-1 reduces SNX3 protein expression and inhibits SNX3-mediated activation of the Wnt/β-catenin signaling pathway. SNX3-IN-1 inhibits the proliferation and migration of pulmonary fibrosis-related cells, and decreases the expression of fibrosis markers α-SMA and COL-1. SNX3-IN-1 can be used in research related to pulmonary fibrosis .
    SNX3-IN-1

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