1947313-60-1
Chemical Structure
Buloxibutid hydrochloride
Synonym(s): AT2 receptor agonist C21 hydrochloride
- CAS No.: 1947313-60-1
- Formula:C23H30ClN3O4S2
- Molecular Weight:512.09
InChIKey: BIIVOXDZWDUHOO-UHFFFAOYSA-N
SMILES: O=C(NS(=O)(C1=C(C2=CC=C(CN3C=NC=C3)C=C2)C=C(CC(C)C)S1)=O)OCCCC.Cl
Biological Activity:
Buloxibutid (AT2 receptor agonist C21) hydrochloride is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid hydrochloride exerts vasodilatory, anti-inflammatory, antifibrotic (promoting the expression of collagenase MMP-13) and tissue repair effects mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway and inflammatory NF-κB pathway. Buloxibutid hydrochloride can be used in research related to idiopathic pulmonary fibrosis, hypertension, systemic sclerosis and other conditions[1][2][3][4].
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Buloxibutid hydrochloride | Buloxibutid (AT2 receptor agonist C21) hydrochloride is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid hydrochloride exerts vasodilatory, anti-inflammatory, antifibrotic (promoting the expression of collagenase MMP-13) and tissue repair effects mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway and inflammatory NF-κB pathway. Buloxibutid hydrochloride can be used in research related to idiopathic pulmonary fibrosis, hypertension, systemic sclerosis and other conditions. |
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- [1]. Rein-Hedin E, et al. Utilizing venous occlusion plethysmography to assess vascular effects: A study with buloxibutid, an angiotensin II type 2 receptor agonist. Clin Transl Sci. 2024;17(2):e13735. [Content Brief]
- [2]. Young ON, et al. Investigational insights into the potential of angiotensin type II receptor agonists as therapeutics for idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2026;35(1):63-73. [Content Brief]
- [3]. Ozhan O, et al. Protective effects of buloxibutid and empagliflozin on hypertension-induced cardiac and vascular injury in rats. J Mol Histol. 2026;57(1):35. Published 2026 Jan 10. [Content Brief]
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[4]. Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004;47(24):5995-6008.
[Content Brief]
Keywords
