11 Results for "

ATG12

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "ATG12" in MCE Product Catalog:

Cat. No.: HY-N0538
CAS No.: 87-99-0
Synonyms: Xylite
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
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Cat. No.: HY-156966
CAS No.: 333351-38-5
Purity:  99.31%
Target:  

Autophagy

Research Areas:  

Cancer

ATG12-ATG3 inhibitor 1 (compound 189) is a potent inhibitor of autophage .
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Cat. No.: HY-RS01140
Research Areas:  

Others

ATG12 Human Pre-designed siRNA Set A contains three designed siRNAs for ATG12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS28006
Research Areas:  

Others

Atg12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Atg12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Cat. No.: HY-RS21488
Research Areas:  

Others

Atg12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atg12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-162932
CAS No.: 2950162-68-0
Target:  

Autophagy

Research Areas:  

Cancer

ATG12-IN-1 (compound 4) is an autophagy inhibitor (IC50=9 μM) targeting the ATG12-ATG3 protein-protein interaction, which can be used in cancer research .
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Cat. No.: HY-P80021

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-W768347
Synonyms: Xylite-13C5
Xylitol- 13C5 (Xylite- 13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
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Cat. No.: HY-P86775
Synonyms: Apg12 antibody; APG12-like antibody; APG12L antibody; ATG12 antibody; ATG12 autophagy related 12 homolog (S. cerevisiae) antibody; ATG12 autophagy related 12 homolog antibody; ATG12_HUMAN antibody; Autophagy 12 antibody; Autophagy-related protein 12 antibody; FBR93 antibody; Apg12 antibody; APG12-like antibody; APG12L antibody; ATG12 antibody; ATG12 autophagy related 12 homolog (S. cerevisiae) antibody; ATG12 autophagy related 12 homolog antibody; ATG12_HUMAN antibody; Autophagy 12 antibody; Autophagy-related protein 12 antibody; FBR93 antibody; HAPG12 antibody; Ubiquitin-like protein ATG12 antibody;

Host:  

Rabbit

Application:  

WB, ICC/IF, FC

Reactivity:  

Human

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Cat. No.: HY-183826
CAS No.: 2841473-91-2
Target:  

Autophagy

Research Areas:  

Infection Cancer

ATG5 PPI-IN-4 is an autophagy inhibitor targeting ATG5, with an IC50 of 12.78 μM against ATG5-ATG16L1 and an IC50 of 12.00 μM against ATG5-TECAIR. ATG5 PPI-IN-4 blocks the protein interactions between ATG5 and ATG16L1, as well as between ATG5 and TECAIR, disrupts the assembly of the ATG12-ATG5-ATG16L1 ternary complex, inhibits the lipidation modification of LC3/ATG8, and ultimately downregulates cellular autophagy levels. ATG5 PPI-IN-4 can be used in autophagy-related research, such as studies on infection and cancer .
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Cat. No.: HY-P86509
Synonyms: Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like protein;

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat

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