87-99-0
87-99-0
Chemical Structure
Xylitol
Synonym(s): Xylite
- CAS No.: 87-99-0
- Formula:C5H12O5
- Molecular Weight:152.15
IUPAC Name: (2R,3r,4S)-pentane-1,2,3,4,5-pentaol
InChIKey: HEBKCHPVOIAQTA-SCDXWVJYSA-N
SMILES: OC[C@@H](O)[C@H](O)[C@@H](O)CO
Biological Activity: Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Xylitol | 99.5% | Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model. | ||||||||||||||||||||
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Xylitol (Standard) | 98.94% | Xylitol (Standard) is the analytical standard of Xylitol. This product is intended for research and analytical applications. Xylitol can be classified as polyols and sugar alcohols. | ||||||||||||||||||||
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Xylitol-5-13C | 99.91% | Xylitol-5-13C is the 13C labeled Xylit. | ||||||||||||||||||||
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Xylitol-13C5 | Xylitol-13C5 (Xylite-13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model. | |||||||||||||||||||||
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Xylitol-1-13C | 99.0% | Xylitol-1-13C is the 13C labeled Xylit. | ||||||||||||||||||||
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Xylitol-2-13C | Xylitol-2-13C is the 13C labeled Xylit. | |||||||||||||||||||||
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Xylitol-d7 | Xylitol-d7 is the deuterium labeled Xylit. | |||||||||||||||||||||
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Ribitol | 99.93% | Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol. | ||||||||||||||||||||
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D-Sorbitol-13C6 | 99.94% | D-Sorbitol-13C6 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement. | ||||||||||||||||||||
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D-Mannitol-13C | 99.9% | D-Mannitol-13C is the 13C labeled D-Mannitol (HY-N0378). D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed. | ||||||||||||||||||||
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D-Mannitol-13C6 | 99.93% | D-Mannitol-13C6 is the 13C labeled D-Mannitol (HY-N0378). D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed. | ||||||||||||||||||||
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DL-Arabitol | DL-Arabitol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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D-Arabitol (Standard) | 99.92% | D-Arabitol (Standard) is the analytical standard of D-Arabitol (HY-N3686). This product is intended for research and analytical applications. D-Arabitol is an orally active D-enantiomer of arabitol. D-Arabitol modulates the composition of gut microbiota, increases short-chain fatty acids, and promotes AMPK-PGC-1α-related browning of white adipose tissue. D-Arabitol improves weight gain, fat accumulation, insulin resistance, lipid deposition and inflammatory responses. D-Arabitol serves as the sole carbon/energy source for Bacillus methanolicus MGA3, a strain that can co-utilize it with mannitol. D-Arabitol is applicable to obesity-related research. | ||||||||||||||||||||
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DL-Mannitol-13C | DL-Mannitol-13C is the 13C-labeled DL-Mannitol. DL-Mannitol is obtained by combining D-mannitol with a sample of Lmannitol obtained by reduction of L-mannono-1, Clactone. | |||||||||||||||||||||
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L-Arabinitol | 98.0% | L-Arabinitol is a potential biomarker for the comsuption of the food products such as sweet potato, deerberry, moth bean, and is also associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency. | ||||||||||||||||||||
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D-Iditol | 98.0% | D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity. | ||||||||||||||||||||
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Dulcite-13C | Dulcite-13C is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact. | |||||||||||||||||||||
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References
- [1]. Cannon M, et al. Effects of Xylitol on Tumor Progression in Syngeneic Mice Cancer Models[J]. Nutraceuticals, 2025, 5(1): 4.
- [2]. Uebanso T, et al. Effects of consuming xylitol on gut microbiota and lipid metabolism in mice[J]. Nutrients, 2017, 9(7): 756. [Content Brief]
- [3]. Park E, et al. Xylitol induces cell death in lung cancer A549 cells by autophagy. Biotechnol Lett. 2015 May;37(5):983-90. [Content Brief]
- [4]. Uittamo J, et al. Xylitol inhibits carcinogenic acetaldehyde production by Candida species. Int J Cancer. 2011 Oct 15;129(8):2038-41. [Content Brief]
