87-99-0
Chemical Structure
Xylitol
Synonym(s): Xylite
- CAS No.: 87-99-0
- Formula:C5H12O5
- Molecular Weight:152.15
IUPAC Name: (2R,3r,4S)-pentane-1,2,3,4,5-pentaol
InChIKey: HEBKCHPVOIAQTA-SCDXWVJYSA-N
SMILES: OC[C@@H](O)[C@H](O)[C@@H](O)CO
Biological Activity: Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Xylitol | 99.5% | Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xylitol (Standard) | 98.94% | Xylitol (Standard) is the analytical standard of Xylitol. This product is intended for research and analytical applications. Xylitol can be classified as polyols and sugar alcohols. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xylitol-5-13C | 98.0% | Xylitol-5-13C is the 13C labeled Xylit. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xylitol-13C5 | Xylitol-13C5 (Xylite-13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xylitol-1-13C | 99.0% | Xylitol-1-13C is the 13C labeled Xylit. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xylitol-2-13C | Xylitol-2-13C is the 13C labeled Xylit. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xylitol-d7 | Xylitol-d7 is the deuterium labeled Xylit. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Cannon M, et al. Effects of Xylitol on Tumor Progression in Syngeneic Mice Cancer Models[J]. Nutraceuticals, 2025, 5(1): 4.
- [2]. Uebanso T, et al. Effects of consuming xylitol on gut microbiota and lipid metabolism in mice[J]. Nutrients, 2017, 9(7): 756. [Content Brief]
- [3]. Park E, et al. Xylitol induces cell death in lung cancer A549 cells by autophagy. Biotechnol Lett. 2015 May;37(5):983-90. [Content Brief]
- [4]. Uittamo J, et al. Xylitol inhibits carcinogenic acetaldehyde production by Candida species. Int J Cancer. 2011 Oct 15;129(8):2038-41. [Content Brief]
