4 Results for "

AZ5104

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "AZ5104" in MCE Product Catalog:

6
6 Cited Publications
Referencia número: HY-B0793
No. CAS: 1421373-98-9
Target:  

EGFR

Áreas de investigación:  

Cancer

AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an EGFR inhibitor with IC50s of 1, 6, 1, 25 and 7 nM for EGFR L858R/T790M, EGFR L858R, EGFR L861Q, EGFR and ErbB4, respectively.
loading...
    loading...
Referencia número: HY-B0793G
No. CAS: 1421373-98-9
AZ-5104 GMP is a GMP-grade form of AZ-5104 (HY-B0793). AZ-5104 is an orally active RORγ receptor-active compound, and also a circulating metabolite of AZD9291. AZ-5104 inhibits sensitizing EGFR mutants, EGFR T790M drug-resistant EGFR mutants and wild-type EGFR, while showing no activity against the IGF-1R family . AZ-5104 can be used in the research of non-small cell lung cancer .
loading...
    loading...
Referencia número: HY-B0793GL
No. CAS: 1421373-98-9
AZ-5104 (GMP-like) is the GMP-like grade of AZ-5104 (HY-B0793). AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an EGFR inhibitor with IC50s of 1, 6, 1, 25 and 7 nM for EGFR L858R/T790M, EGFR L858R, EGFR L861Q, EGFR and ErbB4, respectively.
loading...
    loading...
Referencia número: HY-B0793S1
No. CAS: 2719691-01-5
AZ-5104-d2 is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC50s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively .
loading...
    loading...