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B0445

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By Targets:	Aldehyde Dehydrogenase (ALDH) (1) Drug Derivative (2) Endogenous Metabolite (11) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (1) Reference Standards (1)
By Research Areas:	Metabolic Disease (10)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0445

NAD+ 40+ Cited Publications β-DPN; β-NAD; β-Nicotinamide Adenine Dinucleotide	Endogenous Metabolite	Metabolic Disease
NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-B0445A

NAD sodium 40+ Cited Publications β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium	Endogenous Metabolite	Metabolic Disease
NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .

HY-B0445S

NAD+-13C5 ammonium β-DPN-13C5 ammonium; β-NAD-13C5 ammonium; β-Nicotinamide Adenine Dinucleotide-13C5 ammonium	Isotope-Labeled Compounds	Metabolic Disease
NAD+-13C5 (ammonium) is the ¹³C labled NAD+ (HY-B0445), with an ammonium .

HY-B0445GL

NAD+ (GMP Like) β-DPN (GMP Like); β-NAD (GMP Like); β-Nicotinamide Adenine Dinucleotide (GMP Like)	Endogenous Metabolite	Metabolic Disease
NAD+ (GMP Like) is NAD+ (HY-B0445) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-B0445B

α-NAD α-Nicotinamide Adenine Dinucleotide	Mitochondrial Metabolism Endogenous Metabolite	Metabolic Disease
α-NAD (α-Nicotinamide Adenine Dinucleotide) serves as a substrate for reninase, functions as an analog of β-NAD, affects the kinetics of NAD-dependent enzymes, and also plays a critical role as a cofactor in mitochondrial redox reactions .

HY-B0445AR

NAD sodium (Standard) β-DPN sodium (Standard); β-NAD sodium (Standard); β-Nicotinamide Adenine Dinucleotide sodium (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease
NAD sodium (Standard) is the analytical standard of NAD sodium. This product is intended for research and analytical applications. NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .

HY-W654288

NAD+-d4 β-DPN-d₄; β-NAD-d₄; β-Nicotinamide Adenine Dinucleotide-d₄	Isotope-Labeled Compounds	Others
NAD+-d₄ is the deuterium-labeled NAD+ (HY-B0445). NAD+-d₄ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-164690A

Nicotinamide-guanine dinucleotide sodium	Endogenous Metabolite	Metabolic Disease
Nicotinamide-guanine dinucleotide sodium, a NAD sodium (HY-B0445A) analog, is an oxidized forms of nicotinamide guanine dinucleotide. Nicotinamide-guanine dinucleotide sodium serves as coenzymes for alcohol dehydrogenase (ADH) in vitro .

HY-127127

Deamino-NAD	Endogenous Metabolite	Others
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-127127A

Deamino-NAD sodium	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Metabolic Disease
Deamino-NAD sodium is a structural analog of NAD+ (HY-B0445). Deamino-NAD sodium is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-175106

8-(4-Azidophenacylthio) NAD+ sodium	Drug Derivative	Metabolic Disease
8-(4-Azidophenacylthio) NAD+ sodium is a clickable form of NAD ⁺ (HY-B0445). NAD ⁺ is a coenzyme that transfers hydrogen ions.

HY-134270A

8-Br-7-CH-NAD+ sodium	Drug Derivative	Metabolic Disease
8-Br-7-CH-NAD+ sodium is a derivative of NAD+ (HY-B0445). 8-Br-7-CH-NAD+ sodium can be used to synthesize an antagonist for TRPM2 .

HY-134300A

8-DMA-NAD+ sodium 8-Dimethylamino-NAD+ sodium	Endogenous Metabolite	Others
8-DMA-NAD+ (sodium) (8-Dimethylamino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+ (HY-B0445). 8-DMA-NAD+ (sodium) can be used in the screening of analog-sensitive poly (ADP-ribose) polymerase 1 (PARP1) gatekeeper mutations .

HY-134349A

8-PIP-NAD+ sodium 8-Piperidino-NAD+ sodium	Endogenous Metabolite	Others
8-PIP-NAD+ (sodium) (8-Piperidino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+ (HY-B0445). 8-PIP-NAD+ (sodium) can be used in the determination of poly(ADP-ribose) polymerase (PARP) target proteins. 8-PIP-NAD+ (sodium) is a synthetic intermediate in the synthesis of cyclic ADP-ribose (cADPR) derivatives .

HY-134305A

8-MA-NAD+ sodium 8-Methylamino-NAD+ sodium	Endogenous Metabolite	Others
8-MA-NAD+ (sodium) (8-Methylamino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+ (HY-B0445). 8-MA-NAD+ (sodium) can be used in the screening of analog-sensitive poly (ADP-ribose) polymerase 1 (PARP1) gatekeeper mutations. 8-MA-NAD+ (sodium) can be used in the synthesis of cyclic ADP-ribose (cADPR) derivatives .

NAD+ (GMP Like) β-DPN (GMP Like); β-NAD (GMP Like); β-Nicotinamide Adenine Dinucleotide (GMP Like)	Fluorescent Dyes
NAD+ (GMP Like) is NAD+ (HY-B0445) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

Cat. No.	Product Name	Type

HY-B0445A

NAD sodium 40+ Cited Publications β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium	Biochemical Assay Reagents
NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .

NAD sodium

40+ Cited Publications

β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium

Biochemical Assay Reagents

NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .

HY-B0445GL

NAD+ (GMP Like) β-DPN (GMP Like); β-NAD (GMP Like); β-Nicotinamide Adenine Dinucleotide (GMP Like)	Biochemical Assay Reagents
NAD+ (GMP Like) is NAD+ (HY-B0445) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-B0445AR

NAD sodium (Standard) β-DPN sodium (Standard); β-NAD sodium (Standard); β-Nicotinamide Adenine Dinucleotide sodium (Standard)	Biochemical Assay Reagents
NAD sodium (Standard) is the analytical standard of NAD sodium. This product is intended for research and analytical applications. NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .

NAD sodium (Standard)

β-DPN sodium (Standard); β-NAD sodium (Standard); β-Nicotinamide Adenine Dinucleotide sodium (Standard)

Biochemical Assay Reagents

NAD sodium (Standard) is the analytical standard of NAD sodium. This product is intended for research and analytical applications. NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0445

NAD+ 40+ Cited Publications β-DPN; β-NAD; β-Nicotinamide Adenine Dinucleotide	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-127127

Deamino-NAD	Microorganisms Source Classification	Endogenous Metabolite
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

Cat. No.	Product Name	Chemical Structure

HY-B0445S

NAD+-13C5 ammonium
NAD+-13C5 (ammonium) is the ¹³C labled NAD+ (HY-B0445), with an ammonium .

HY-W654288

NAD+-d4
NAD+-d₄ is the deuterium-labeled NAD+ (HY-B0445). NAD+-d₄ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0445GL

NAD+ (GMP Like) β-DPN (GMP Like); β-NAD (GMP Like); β-Nicotinamide Adenine Dinucleotide (GMP Like)	Endogenous Metabolite	Metabolic Disease
NAD+ (GMP Like) is NAD+ (HY-B0445) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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B0445

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

GMP Molecules

Natural
Products