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BMI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BMI1 (11) Aminopeptidase (1) Apoptosis (7) Autophagy (4) CDK (1) E1/E2/E3 Enzyme (4) Estrogen Receptor/ERR (1) Fluorescent Dye (1) Histone Methyltransferase (1) HIV (1) HIV Integrase (1) Ligands for Target Protein for PROTAC (1) Microtubule/Tubulin (1) PROTACs (2) Reference Standards (1) Small Interfering RNA (siRNA) (3) γ-Glutamyl Transferase (GGT) (1)
By Research Areas:	Cancer (17) Infection (1) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
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Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139514

RB-3	E1/E2/E3 Enzyme	Cancer
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to *RING1B-BMI1f, with a K_d* of 2.8 μM .

HY-15888

PTC-209 Maximum Cited Publications 16 Publications Verification	BMI1 Autophagy	Cancer
PTC-209 is a specific *BMI-1* inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment .

HY-112041

Unesbulin 3 Publications Verification PTC596	BMI1 Apoptosis	Cancer
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity .

HY-W010937

1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide BMIM-TFSI; BMI-TFSI	HIV HIV Integrase	Infection
1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMIM-TFSI; BMI-TFSI) is an HIV-1 integrase inhibitor. 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide weakly inhibits recombinant HIV-1 integrase 3'-processing or strand transfer activity. 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide can be used for the research of HIV-1 .

HY-103696

PTC-028 2 Publications Verification	BMI1 Apoptosis	Cancer
PTC-028 is an orally bioavailable inhibitor of stem cell factor *BMI-1* in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis .

HY-160924

MS147	PROTACs BMI1 E1/E2/E3 Enzyme Histone Methyltransferase	Cancer
MS147 is a VHL-based PROTAC degrader of *BMI1* and RING1B (polycomb repressive complex 1 core components). MS147 directly binds EED and VHL E3 ligase, recruiting the ligase to the EED-BMI1/RING1B complex to induce time-dependent, ubiquitination-mediated degradation of BMI1 and RING1B. MS147 reduces histone H₂A Lys119 mono-ubiquitination without altering histone H₃ Lys27 tri-methylation and inhibits cancer cells proliferation. MS147 can be used for the research of cancer, such as chronic myelogenous leukemia and b-cell lymphoma . (Pink: BMI1/RING1B ligand (HY-183634); Blue: VHL ligand (HY-125845); Black: linker)

HY-170823

PRC1-IN-1	E1/E2/E3 Enzyme	Cancer
PRC1-IN-1 is a PRC1 complex inhibitor. PRC1-IN-1 binds to both RING1A and RING1B proteins, and inhibits the activities of RING1B-BMI1 and RING1B-PCGF1. PRC1-IN-1 effectively inhibits H2AK119 ubiquitination and induces cell differentiation in leukemia cells. PRC1-IN-1 can be used for the research of leukemia .

HY-158239

MS181	PROTACs E1/E2/E3 Enzyme	Cancer
MS181 (compound 1) is a potent cereblon (CRBN)-recruiting and EED-binding polycomb repressive complex 1 (PRC1) PROTAC degrader. MS181 decreases the expression of EED, EZH2, SUZ12, BMI1 and RING1B. MS181 shows antiproliferative activity (Strtucture Note: Red, EED binder (HY-158771); Blue, CRBN ligand (HY-41547); Black, Linker HY-131717) .

HY-15888A

PTC-209 hydrobromide Maximum Cited Publications 16 Publications Verification	BMI1 Autophagy	Cancer
PTC-209 hydrobromide is a specific *BMI-1* inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment .

HY-123369

BMI-1026	CDK Apoptosis	Cancer
BMI-1026 is a cyclin-dependent kinase 1 (Cdk1) inhibitor with IC₅₀ of 2.3 nM. BMI-1026 induces apoptosis by arresting the G2-M phase .

HY-143655

QW24	BMI1 Autophagy	Cancer
QW24 exerts potent anti-tumor activity by down-regulating *BMI-1* and is used as an effective therapeutic agent for clinical colorectal cancer research.

HY-116126

Leuhistin	Aminopeptidase	Cancer
Leuhistin is an AP-M (aminopeptidase-M) inhibitor. AP-M is an inactivating enzyme of bioactive peptides in cerebral membranes. Leuhistin can be produced by Bacillus laterosporus BMI156-14F1 .

HY-164463

BMI-135	Estrogen Receptor/ERR Apoptosis	Cancer
BMI-135 is a selective estrogen mimic, that exhibits agonist activity for estrogen receptor. BMI-135 induces rapid endoplasmic reticulum stress response (UPR) and apoptosis in breast cancer cells .

HY-146343

BMI-Glu	Fluorescent Dye γ-Glutamyl Transferase (GGT)	Inflammation/Immunology Cancer
BMI-Glu is a selective γ-glutamyl transpeptidase (GGT) fluorescent probe with a K_m of 69.63 µM. BMI-Glu has high sensitivity, good water solubility and biocompatibility .

HY-RS01532

BMI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMI1 Human Pre-designed siRNA Set A contains three designed siRNAs for BMI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMI1 Human Pre-designed siRNA Set A BMI1 Human Pre-designed siRNA Set A

HY-RS18603

Bmi1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bmi1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmi1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bmi1 Mouse Pre-designed siRNA Set A Bmi1 Mouse Pre-designed siRNA Set A

HY-143658

SH498	BMI1 Autophagy	Cancer
SH498, a novel *Bmi-1-mediated* antitumor agent, shows potent antiproliferative activity.

HY-172617

APD-94	BMI1 Microtubule/Tubulin Apoptosis	Cancer
APD-94 is a dual inhibitor targeting tubulin and *Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis*, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study .

HY-N0992

1,6,7-Trihydroxyxanthone	BMI1 Apoptosis	Cancer
1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16 .

HY-183634

BMI1/RING1B ligand-1	Ligands for Target Protein for PROTAC BMI1	Others
BMI1/RING1B ligand-1 is a *BMI1/RING1B* ligand. BMI1/RING1B ligand-1 can be used to synthesize PROTAC S147 (HY-160924).

HY-RS25088

Bmi1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bmi1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bmi1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bmi1 Rat Pre-designed siRNA Set A Bmi1 Rat Pre-designed siRNA Set A

HY-103696R

PTC-028 (Standard)	BMI1 Reference Standards Apoptosis	Cancer
PTC-028 (Standard) is the analytical standard of PTC-028 (HY-103696). This product is intended for research and analytical applications. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis .

Leuhistin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Aminopeptidase
Leuhistin is an AP-M (aminopeptidase-M) inhibitor. AP-M is an inactivating enzyme of bioactive peptides in cerebral membranes. Leuhistin can be produced by Bacillus laterosporus BMI156-14F1 .

1,6,7-Trihydroxyxanthone	Natural Products Goodyera oblongifolia Raf. Orchidaceae Plants Source Classification	BMI1 Apoptosis
1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16 .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701224

	BMI1 Protein, Human (His) ELAV1; Hua; HUR; MelG	Human	E. coli
	BMI1 Protein, a component of the Polycomb group PRC1-like complex, maintains transcriptional repression in genes, including Hox genes, by monoubiquitinating histone H2A. It regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. Interacts with various partners in the PRC1-like complex, such as RNF2, CBX2, CBX4, CBX8, PHC1, PHC2, PHC3, and UB2D3, forming complexes crucial for chromatin modification and gene expression control. BMI1 Protein, Human (E.coli,N-His) is the recombinant human-derived BMI1 protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (3) Rat (4) Mouse (4)
Application:	IHC-P (3) ICC/IF (5) IP (3) WB (5) FC (2) ELISA (2)
Isotype:	IgG,Kappa (1) IgG (2) IgG2a (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80034

	Bmi-1 Antibody (YA821) 1 Publications Verification	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Bmi-1 Antibody (YA821) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Bmi-1.

HY-P87926

	Bmi-1 Antibody (YA7611)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bmi-1 Antibody (YA7611) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Bmi-1.

HY-P85060

	Bmi-1 Antibody (YA4752) BMI1; PCGF4; RNF51; Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51	WB, IHC-P, ICC/IF, FC, ELISA	Human
	Bmi-1 Antibody (YA4752) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Bmi-1.

HY-P81800

	PCGF6 Antibody (YA1545) RING finger protein 134; Mel18 and BMI1-like RING finger	WB, ICC/IF, IP	Mouse, Rat
	PCGF6 Antibody (YA1545) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCGF6.

HY-P81800A

	PCGF6 Antibody (YA1545)(PBS only) RING finger protein 134; Mel18 and BMI1-like RING finger	WB, ICC/IF, IP	Mouse, Rat
	PCGF6 Antibody (YA1545) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCGF6.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

BMI1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BMI1 Human Pre-designed siRNA Set A contains three designed siRNAs for BMI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bmi1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bmi1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmi1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bmi1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bmi1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bmi1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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