2396639-29-3
2396639-29-3
Chemical Structure
PRC1-IN-1
- CAS No.: 2396639-29-3
- Formula:C24H19ClFN3O2
- Molecular Weight:435.88
InChIKey: CWMDJTCNUCJTSW-UHFFFAOYSA-N
SMILES: CC(C1=C(NC(C(O)=O)=C1C2=C(C=CC3=C2C=CN3)Cl)C4=CC(F)=CC5=C4C=CN5)C
Biological Activity: PRC1-IN-1 is a PRC1 complex inhibitor. PRC1-IN-1 binds to both RING1A and RING1B proteins, and inhibits the activities of RING1B-BMI1 and RING1B-PCGF1. PRC1-IN-1 effectively inhibits H2AK119 ubiquitination and induces cell differentiation in leukemia cells. PRC1-IN-1 can be used for the research of leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PRC1-IN-1 | 97.30% | PRC1-IN-1 is a PRC1 complex inhibitor. PRC1-IN-1 binds to both RING1A and RING1B proteins, and inhibits the activities of RING1B-BMI1 and RING1B-PCGF1. PRC1-IN-1 effectively inhibits H2AK119 ubiquitination and induces cell differentiation in leukemia cells. PRC1-IN-1 can be used for the research of leukemia. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.85
HY-139514RB-3 -
Similarity Score 0.50
HY-141858Lynamicin B -
Similarity Score 0.47
HY-173472MBL-IN-5 -
Similarity Score 0.45
HY-10617DRucaparib acetate -
Similarity Score 0.45
HY-108343RWEE1-IN-4 (Standard) -
Similarity Score 0.45
HY-155736MAPK-IN-2 -
Similarity Score 0.44
HY-139970VPC-13789 -
Similarity Score 0.44
HY-113567GSK2324 -
Similarity Score 0.44
HY-108531ER 50891 -
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