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Basidiomycetes

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By Targets:	Antibiotic (4) Bacterial (3) Biochemical Assay Reagents (2) DNA/RNA Synthesis (1) Drug Derivative (1) Endogenous Metabolite (2) Environmental Pollutants (3) Fungal (15) Glycosidase (1) Interleukin Related (1) Mitochondrial Metabolism (1) Phosphatase (1) PKC (1) PPAR (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) SOD (1) Succinate Dehydrogenase (1) TNF Receptor (2)
By Research Areas:	Cancer (2) Endocrinology (1) Infection (18) Inflammation/Immunology (2) Metabolic Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126224

*Driselase, Basidiomycetes* sp**	Biochemical Assay Reagents	Others
Driselase, Basidiomycetes sp, a complex mixt. of wall-digesting enzymes, is a specific commercial fungal protoplasting enzyme preparation. Driselase can be used in combination with lyase to promote protoplast formation in fungi. Driselase is by far the most potent of the enzymes tested for polysaccharide digestion and greatly increases both tensile and indentation compliances, yet it does not induce wall creep, even after 6 h of digestion .

HY-A0278

Hexaconazole (-)-Hexaconazol	Environmental Pollutants Reactive Oxygen Species (ROS) Fungal SOD	Infection Endocrinology
Hexaconazole is a demethylation enzyme inhibitor and a synthetic fungicide that targets many fungi, especially ascomycetes and basidiomycetes, and it can enhance the activity of SOD and peroxidase. Hexaconazole causes endocrine disorders in zebrafish larvae .

HY-17520

Penthiopyrad 1 Publications Verification MTF-753	Environmental Pollutants Fungal	Infection
Penthiopyrad (MTF-753) is a carboxamide Fungicide. Penthiopyrad inhibits SDH. Penthiopyrad exhibits broad-spectrum antifungal activity, being effective not only against Basidiomycetes, but also against Ascomycetes and Deuteromycetes. Penthiopyrad inhibits the mycelial growth of Alternaria mali, Botrytis cinerea, Monilinia mali, Rhizoctonia solani and Sclerotinia sclerotiorum on PDA medium, with EC₅₀ values ranging from <0.4 ppm to 0.34 ppm and MIC values ranging from 6.6 ppm to 47.9 ppm .

HY-B2011

Flutolanil	Environmental Pollutants Succinate Dehydrogenase Fungal Mitochondrial Metabolism	Infection
Flutolanil is a succinate dehydrogenase complex inhibitor and fungicide. Flutolanil blocks electron transfer between the redox center of succinate dehydrogenase and coenzyme Q, inhibits mycelial oxygen consumption, and suppresses mycelial growth. Flutolanil induces acute and sublethal toxicity in zebrafish at different life stages. Flutolanil can be used in studies on plant disease control .

HY-N9768

(10E,12E)-9-Oxo-10,12-octadecadienoic acid 9-oxo-ODA	Fungal PPAR	Infection
(10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist that can be isolated from the basidiomycete Gomphus floccosus. (10E,12E)-9-Oxo-10,12-octadecadienoic acid enhances fatty acid oxidation through PPARα activation, thereby inhibiting triglyceride accumulation. (10E,12E)-9-Oxo-10,12-octadecadienoic acid also has antifungal (Fungal) activity .

HY-121387

Furmecyclox	Fungal	Infection
Furmecyclox is an effective fungicide. Furmecyclox shows great effects against basidiomycetes .

HY-148054

Antifungal agent 36	Fungal	Infection
Antifungal agent 36 is a potent anti-fungal agent. Antifungal agent 36 shows anti-fungal activity for Basidiomycetes .

HY-125652

Macrosphelide A	Antibiotic	Infection
Macrosphelide A is a macrolide antibiotic. Macrosphelide A inhibits growth of some ascomycetes, basidiomycetes, oomycetes and all four Gram-positive bacteria tested, including the medically important Staphylococcus aureus with a MIC of ≤500 μg/mL .

HY-N15600

Merulidial (-)-Merulidial	Antibiotic Fungal Bacterial DNA/RNA Synthesis	Infection Cancer
Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC₅₀ s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .

HY-124408

Mepronil	Fungal	Infection
Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection .

HY-124408R

Mepronil (Standard)	Reference Standards Fungal	Infection
Mepronil (Standard) is the analytical standard of Mepronil. This product is intended for research and analytical applications. Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection .

HY-N8409

FD-838	Others	Others
FD-838 is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .

HY-N9533

16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid	Others	Others
16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid is a lanostanoid that can be found in the Sri Lankan basidiomycete Ganoderma applanatum .

HY-N14548

Cryptosporiopsin	Antibiotic Bacterial	Infection
Cryptosporiopsin can be isolated from the strain of Cryptosporiopsis sp. and Sporormia affinis. Cryptosporiopsin has antibacterial activity to many kinds of basidiomycetes, algal fungi, ascomycetes and hemiplegia fungi that cause wood rot, and can inhibit spore germination of Phytophthora potatoes. Cryptosporiopsin also has certain activity against gram-positive bacteria and negative bacteria .

HY-N12776

Illudalic acid	Phosphatase	Cancer
Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC₅₀ value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue .

HY-W746764

E-α-Bisabolene	Endogenous Metabolite Fungal	Infection
E-α-Bisabolene is a non-cyclic sesquiterpene. E-α-Bisabolene holds a central position in the metabolic network of Phanerochaete chrysosporium. E-α-Bisabolene can be utilized by white-rot fungi for the biosynthesis of secondary metabolites .

HY-W043791

4-Dodecyl-2,6-dimethylmorpholine	Fungal	Infection
4-Dodecyl-2,6-dimethylmorpholine is a morpholine fungicide and plant-growth regulator. 4-Dodecyl-2,6-dimethylmorpholine targets phytopathogenic fungi including Oomycetes, Ascomycetes and Basidiomycetes. 4-Dodecyl-2,6-dimethylmorpholine acts synergistically with acylalanine fungicides to enhance antifungal efficacy and regulate plant growth. 4-Dodecyl-2,6-dimethylmorpholine can be applied to the study of plant fungal diseases and phytopathogenic fungal infections .

HY-N8403

Vibralactone B	Others	Others
Vibralactone B is a Sesquiterpenoids product that can be isolated from From the cultures of the Basidiomycete Boreostereum vibrans. .

HY-N3104

Paxiphylline E Daphnilongeranine A N-oxide	Others	Others
Paxiphylline E (Daphnilongeranine A N-oxide) is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .

HY-N8942

(S)-17-Hydroxy-18,20-ene-neogrifolin	Others	Others
(S)-17-Hydroxy-18,20-ene-neogrifolin is a natural product that can be isolated from the Basidiomycete Albatrellus Caeruleoporus .

HY-N9255

2-Methyl-6-(p-tolyl)heptane-2,3-diol	Drug Derivative	Others
2-Methyl-6-(p-tolyl)heptane-2,3-diol is a natural sesquiterpene.

HY-N8523

Vibralactone D	Others	Metabolic Disease
Vibralactone D (Compound 1) is a metabolite isolated and cultured from natural basidiomycetes Boreostereum vibrans. Vibralactone D shows weak inhibitory activity against isoenzymes of 11b-hydroxysteroid dehydrogenase (HSD) (IC₅₀ 85.7 μM).

HY-182477

Siccayne	Antibiotic Bacterial Fungal	Infection
Siccayne, found in the marine basidiomycete Halocyphina villosa and deuteromycete Helminthosporium siccans, is an antibiotic. Siccayne interferes with nucleotide incorporation into DNA and RNA, precursor transport enzymatic reactions, and essential macromolecule synthesis. Siccayne inhibits Gram-positive bacteria and some fungi. Siccayne can be used for research on infections caused by bacteria and fungi .

HY-182630

CJ-14897	Interleukin Related TNF Receptor	Inflammation/Immunology
CJ-14897 is a cytokine production inhibitor, with IC₅₀ values of 0.059 μM and 0.59 μM for IL-1β and TNF-α production, respectively, and an IC₅₀ of 180 μM for leucine uptake. CJ-14897 is isolated from the fermentation broth of the basidiomycete Marasmius strain CL21624 .

HY-132188A

Manganese Peroxidase, Nematoloma frowardii	Biochemical Assay Reagents	Metabolic Disease
Manganese Peroxidase, Nematoloma frowardii (EC 1.11.1.13) is a hemecontaining glycoprotein that is produced by ligninolytic basidiomycetes. It requires hydrogen peroxide as an oxidant. Manganese Peroxidase, Nematoloma frowardii (EC 1.11.1.13) oxidizes Mn2+ to Mn3+. Mn3+ oxidizes phenolic rings to phenoxy radicals which results in the decomposition of various compounds.

HY-149151

Variegatic acid	Endogenous Metabolite PKC Glycosidase TNF Receptor Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Variegatic acid is a secondary metabolite derived from basidiomycete fungi. Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM. Variegatic acid inhibits antigen- or calcium ionophore-induced β-hexosaminidase release (IC₅₀ values of 10.4 μM and 22.2 μM, respectively) and TNF-α secretion (IC₅₀ values of 16.8 μM and 20.1 μM, respectively). Variegatic acid suppresses the enzymatic activity of calcium-activated PKCβ1 and reduces Fe(III) to Fe(II) in a pH-dependent manner, enabling the generation of hydroxyl radicals (·OH) through reaction with H₂O₂, which facilitates the degradation of lignocellulose. Variegatic acid is useful for studying biological degradation and allergic responses.

HY-182471

Aminopyrifen	Fungal	Infection
Aminopyrifen is a GWT-1 inhibitor. Aminopyrifen inhibits the inositol acylation of phosphatidylinositol, disrupting the maturation process of GPI-anchored proteins and the integrity of fungal cell walls. Aminopyrifen strongly inhibits germ tube elongation of Botrytis cinerea, delays spore germination, prevents appressorium formation, and blocks the infection of plant tissues by pathogenic fungi. Aminopyrifen is effective against field populations of eggplant gray mold and cucumber powdery mildew, and can be used for research on various plant fungal diseases such as gray mold and powdery mildew .

HY-165191

LY214352	Fungal	Infection
LY214352 is an antifungal agent that targets dihydroorotate dehydrogenase (DHO-DH). LY214352 exhibits antifungal activity against Aspergillus nidulans and agriculturally important ascomycete fungi. LY214352 can be used in studies related to grape gray mold, apple scab, and fungal infections caused by ascomycetes .

HY-121443

Cyflufenamid	Fungal	Infection
Cyflufenamid is an oxime amide fungicide. Cyflufenamid inhibits the formation of haustoria, colonies and spores of Blumeria graminis f. sp. tritici, and prevents germ tube elongation of Monilinia fructicola. Cyflufenamid is applicable to research related to powdery mildew and brown rot .

(10E,12E)-9-Oxo-10,12-octadecadienoic acid 9-oxo-ODA	Microorganisms Ketones, Aldehydes, Acids Source Classification	Fungal PPAR
(10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist that can be isolated from the basidiomycete Gomphus floccosus. (10E,12E)-9-Oxo-10,12-octadecadienoic acid enhances fatty acid oxidation through PPARα activation, thereby inhibiting triglyceride accumulation. (10E,12E)-9-Oxo-10,12-octadecadienoic acid also has antifungal (Fungal) activity .

Macrosphelide A	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	Antibiotic
Macrosphelide A is a macrolide antibiotic. Macrosphelide A inhibits growth of some ascomycetes, basidiomycetes, oomycetes and all four Gram-positive bacteria tested, including the medically important Staphylococcus aureus with a MIC of ≤500 μg/mL .

Merulidial (-)-Merulidial	Microorganisms Antibiotics Source Classification	Antibiotic Fungal Bacterial DNA/RNA Synthesis
Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC₅₀ s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .

FD-838	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
FD-838 is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .

16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid	Triterpenes Microorganisms Classification of Application Fields Terpenoids Other Diseases Disease Research Fields Source Classification	Others
16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid is a lanostanoid that can be found in the Sri Lankan basidiomycete Ganoderma applanatum .

Cryptosporiopsin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Cryptosporiopsin can be isolated from the strain of Cryptosporiopsis sp. and Sporormia affinis. Cryptosporiopsin has antibacterial activity to many kinds of basidiomycetes, algal fungi, ascomycetes and hemiplegia fungi that cause wood rot, and can inhibit spore germination of Phytophthora potatoes. Cryptosporiopsin also has certain activity against gram-positive bacteria and negative bacteria .

Illudalic acid	Microorganisms Terpenoids Sesquiterpenes Source Classification	Phosphatase
Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC₅₀ value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue .

E-α-Bisabolene	Structural Classification Terpenoids Sesquiterpenes Artemisia granatensis boiss Umbelliferae Plants Source Classification	Endogenous Metabolite Fungal
E-α-Bisabolene is a non-cyclic sesquiterpene. E-α-Bisabolene holds a central position in the metabolic network of Phanerochaete chrysosporium. E-α-Bisabolene can be utilized by white-rot fungi for the biosynthesis of secondary metabolites .

Vibralactone B	Microorganisms Terpenoids Sesquiterpenes Source Classification	Others
Vibralactone B is a Sesquiterpenoids product that can be isolated from From the cultures of the Basidiomycete Boreostereum vibrans. .

Paxiphylline E Daphnilongeranine A N-oxide	Daphniphyllum paxianum K. Rosenth. Alkaloids Pyrrole Alkaloids Plants Source Classification	Others
Paxiphylline E (Daphnilongeranine A N-oxide) is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .

(S)-17-Hydroxy-18,20-ene-neogrifolin	Microorganisms Classification of Application Fields Other Diseases Phenols Polyphenols Disease Research Fields Source Classification	Others
(S)-17-Hydroxy-18,20-ene-neogrifolin is a natural product that can be isolated from the Basidiomycete Albatrellus Caeruleoporus .

2-Methyl-6-(p-tolyl)heptane-2,3-diol	Structural Classification Natural Products Microorganisms Source Classification	Drug Derivative
2-Methyl-6-(p-tolyl)heptane-2,3-diol is a natural sesquiterpene.

Vibralactone D	Natural Products Microorganisms Source Classification	Others
Vibralactone D (Compound 1) is a metabolite isolated and cultured from natural basidiomycetes Boreostereum vibrans. Vibralactone D shows weak inhibitory activity against isoenzymes of 11b-hydroxysteroid dehydrogenase (HSD) (IC₅₀ 85.7 μM).

Variegatic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite PKC Glycosidase TNF Receptor Reactive Oxygen Species (ROS)
Variegatic acid is a secondary metabolite derived from basidiomycete fungi. Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM. Variegatic acid inhibits antigen- or calcium ionophore-induced β-hexosaminidase release (IC₅₀ values of 10.4 μM and 22.2 μM, respectively) and TNF-α secretion (IC₅₀ values of 16.8 μM and 20.1 μM, respectively). Variegatic acid suppresses the enzymatic activity of calcium-activated PKCβ1 and reduces Fe(III) to Fe(II) in a pH-dependent manner, enabling the generation of hydroxyl radicals (·OH) through reaction with H₂O₂, which facilitates the degradation of lignocellulose. Variegatic acid is useful for studying biological degradation and allergic responses.

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Basidiomycetes

Inhibitors & Agonists

NaturalProducts

Natural
Products