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Benzothiazole

" in MedChemExpress (MCE) Product Catalog:

45

Inhibitors & Agonists

3

Fluorescent Dye

1

Biochemical Assay Reagents

1

Peptides

2

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Products

1

Isotope-Labeled Compounds

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0218
    Thioflavin T
    25+ Cited Publications

    Basic Yellow 1

    		 Amyloid-β Others
    Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Excitation max.: ~385 nm (free); ~450 nm (bound); Emission max.: ~445 nm (free); ~485 nm (bound) .
    Thioflavin T
  • HY-W012634
    Benzothiazole

    		Environmental Pollutants Bacterial Infection Metabolic Disease Inflammation/Immunology Cancer
    Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent [1][2][3][4].
    Benzothiazole
  • HY-108896
    Icatibant acetate
    10+ Cited Publications

    HOE 140 acetate

    		 Bradykinin Receptor Inflammation/Immunology
    Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively .
    Icatibant acetate
  • HY-10862
    FAAH inhibitor 1

    Benzothiazole analog 3

    		 FAAH Autophagy Neurological Disease Cancer
    FAAH inhibitor 1 (compound 3) is a selective reversible FAAH inhibitor. FAAH inhibitor 1 has no off-target activity with respect to other serine hydrolases. FAAH inhibitor 1 is exclusively specific against FAAH in rat brain with an IC50 value of 18 nM and had no missing protein bands in all the other tissues. FAAH inhibitor 1 can be used for neurological disorders research .
    FAAH inhibitor 1
  • HY-W040269
    Dehydrothio-p-toluidine
    1 Publications Verification

    DHPT

    		 Fluorescent Dye Others
    Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production. Dehydrothio-p-toluidine shows inhalation toxicity in acute and subchronic conditions .
    Dehydrothio-p-toluidine
  • HY-DY1049
    Thioflavin T (solution)

    		Amyloid-β Others
    Thioflavin T (solution) is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Excitation max.: ~385 nm (free) ; ~450 nm (bound) ; Emission max.: ~445 nm (free) ; ~485 nm (bound) .
    Solvent and Concentration: Sterile water: 10 mM
    The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
    Thioflavin T (solution)
  • HY-W012634S
    Benzothiazole-d4

    		Isotope-Labeled Compounds Bacterial Cancer
    Benzothiazole-d4 is a deuterium labeled Benzothiazole (HY-W012634). Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral .
    Benzothiazole-d4
  • HY-D2344
    3-BTD

    3-Benzothiazole-daphnetin

    		 Fluorescent Dye Others
    3-BTD (3-Benzothiazole-daphnetin) is a Catechol-O-methyltransferase (COMT) two-photon fluorescence probe. 3-BTD can also be used for biological imaging of endogenous COMT in living cells and tissue sections .
    3-BTD
  • HY-134801
    CID1231538

    		GPR35 Metabolic Disease Inflammation/Immunology
    CID1231538, a benzothiazole analog, is a potent GPR35 antagonist with no significant activity against rodent orthologs of GPR35, which is also a G protein-coupled receptor (GPCR) .
    CID1231538
  • HY-18402
    2-(Methylthio)benzothiazole

    		Drug Derivative Cardiovascular Disease
    2-(Methylthio)benzothiazole is a derivative of 2-Mercaptobenzothiazole (HY-W017113). 2-(Methylthio)benzothiazole reduces heart rate, causes pericardial edema and deformity, delays cardiac maturation, decreases stroke volume and cardiac output, and leads to vascular structural defects in zebrafish larvae .
    2-(Methylthio)benzothiazole
  • HY-145766
    Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine

    		Biochemical Assay Reagents Others
    Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine is an active compound .
    Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine
  • HY-105084A
    Lubeluzole dihydrochloride

    		Sodium Channel Calcium Channel Cardiovascular Disease Infection Neurological Disease Cancer
    Lubeluzole dihydrochloride is the dihydrochloride salt of Lubeluzole (HY-105084). Lubeluzole dihydrochloride is the S-isomer of benzothiazole derivative. Lubeluzole dihydrochloride can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole dihydrochloride exhibits anti-ischemic and neuroprotective effects. Lubeluzole dihydrochloride also shows anti-bacterial and anti-diarrheal potential. Lubeluzole dihydrochloride can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole dihydrochloride can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole dihydrochloride can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .
    Lubeluzole dihydrochloride
  • HY-75577
    4-Amino-3-methoxybenzoic acid

    		Drug Intermediate Cancer
    4-Amino-3-methoxybenzoic acid is a drug intermediate that can be used to construct benzothiazole compounds with anti-breast cancer activity .
    4-Amino-3-methoxybenzoic acid
  • HY-139432
    2-(Morpholinothio)benzothiazole

    		Biochemical Assay Reagents Others
    2-(Morpholinothio)benzothiazole is an accelerator that can be used for amperometric measurements .
    2-(Morpholinothio)benzothiazole
  • HY-147973
    IZTZ-1

    		c-Myc Apoptosis Cancer
    IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research .
    IZTZ-1
  • HY-151581
    HCVcc-IN-1

    		Virus Protease Infection
    HCVcc-IN-1 is a benzothiazole-2-thiophene S-glycoside derivative with low toxic and antiviral activity .
    HCVcc-IN-1
  • HY-105084
    Lubeluzole

    		Sodium Channel Calcium Channel Infection Cardiovascular Disease Neurological Disease Cancer
    Lubeluzole is the S-isomer of benzothiazole derivative. Lubeluzole can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole exhibits anti-ischemic and neuroprotective effects. Lubeluzole also shows anti-bacterial and anti-diarrheal potential. Lubeluzole can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .
    Lubeluzole
  • HY-179415
    DHFR-IN-24

    		Dihydrofolate reductase (DHFR) Bacterial Infection
    DHFR-IN-24, a benzothiazole derivative, is a dihydrofolate reductase (DHFR) inhibitor. DHFR-IN-24 has intrinsic antibacterial activity against both Gram-positive and Gram-negative strains. DHFR-IN-24 synergistically combines DHFR inhibition with photodynamic therapy (PDT) for enhanced antibacterial activity against multidrug-resistant pathogens .
    DHFR-IN-24
  • HY-W012634R
    Benzothiazole (Standard)

    		Reference Standards Bacterial Infection Metabolic Disease Inflammation/Immunology Cancer
    Benzothiazole (Standard) is the analytical standard of Benzothiazole. This product is intended for research and analytical applications. Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent .
    Benzothiazole (Standard)
  • HY-W019633
    Benzothiazole-5-boronic acid pinacol ester

    		Biochemical Assay Reagents Others
    Benzothiazole-5-boronic acid pinacol ester is a compound that can be used in the boronate part of Suzuki coupling reactions .
    Benzothiazole-5-boronic acid pinacol ester
  • HY-151536
    meso-Benzothiazole-BODIPY 505/515

    		Fluorescent Dye Neurological Disease
    meso-Benzothiazole-BODIPY 505/515 is a boron dipyrromethenes (BODIPY) -based fluorescent probeBenzothiazole-BODIPY 505/515 can monitor cellular viscosity changes and autophagy. meso-Benzothiazole-BODIPY 505/515 can be used for the research of Alzheimer’s diseases, lysosomal storage diseases and neural degeneration diseases .
    meso-Benzothiazole-BODIPY 505/515
  • HY-141043
    N,N'-bis-(Acid-PEG3)-benzothiazole Cy5

    		PROTAC Linkers Cancer
    N,N'-bis-(Acid-PEG3)-benzothiazole Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    N,N'-bis-(Acid-PEG3)-benzothiazole Cy5
  • HY-145755
    Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine

    		Biochemical Assay Reagents Others
    Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine alters the lifespan of a eukaryotic organism .
    Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine
  • HY-141038
    N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5

    		PROTAC Linkers Cancer
    N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5
  • HY-141064
    N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5

    		PROTAC Linkers Cancer
    N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5
  • HY-163826
    Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph

    		Ligands for E3 Ligase Cancer
    Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand for E3 ubiquitin ligase. Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph can be connected to the ligand for protein by a linker to form 22-SLF (HY-163807) .
    Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph
  • HY-19054
    CGP-20376

    		Parasite Infection
    CGP-20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of Benzothiazole (HY-W012634), is an orally active and potent antifilarial drug. CGP-20376 has anthelmintic activity .
    CGP-20376
  • HY-120622
    BMS-243117

    		Src Cancer
    BMS-243117 is a potent, and selective benzothiazole based p56 Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck .
    BMS-243117
  • HY-151588
    Anticancer agent 90

    		Virus Protease Cancer
    Anticancer agent 90 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity. Anticancer agent 90 has high inhibition against the two cell line from ovarian cancer (OVCAR-4), renal cancer (A498) .
    Anticancer agent 90
  • HY-151592
    Anticancer agent 91

    		Antibiotic Cancer
    Anticancer agent 91 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. Anticancer agent 91 has high inhibition against the two cell line from CNS cancer (SF-539 and SNB-75) .
    Anticancer agent 91
  • HY-151587
    Anticancer agent 89

    		Others Cancer
    Anticancer agent 89 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity, has high inhibition against the three cell line from ovarian cancer (OVCAR-4), renal cancer (A498), and melanoma (SK-MEL-5) .
    Anticancer agent 89
  • HY-151589
    HCVcc-IN-2

    		Virus Protease Infection Cancer
    HCVcc-IN-2 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. HCVcc-IN-2 has high inhibition against the three cell line from CNS cancer (SF-539 and SNB-75), colon cancer (HCT-116), and renal cancer (A498) .
    HCVcc-IN-2
  • HY-179046
    VEGFR-2-IN-78

    		VEGFR Cancer
    VEGFR-2-IN-78 (Compound 6b) is a potent VEGFR-2 inhibitor with an IC50 of 0.21 μM. VEGFR-2-IN-78 exhibits selective cytotoxicity against A-498 and MDA-MB-231 cells. VEGFR-2-IN-78 has antioxidant activity. VEGFR-2-IN-78 can be used in anti-angiogenesis research .
    VEGFR-2-IN-78
  • HY-149925
    DNA Gyrase-IN-6

    		Bacterial DNA/RNA Synthesis Topoisomerase Infection
    Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor .
    DNA Gyrase-IN-6
  • HY-W176465
    BTA-2

    		Amyloid-β Others
    BTA-2, a benzothiazole dye, is structurally similar to thioflavin T (ThT), which exhibits an enhanced fluorescence signal when bound to amyloid fibrils. BTA-2 has distinct absorption and emission characteristics in solution and when bound to amyloid fibrils, which makes it can used for identifying amyloid fibrils using spectroscopy .
    BTA-2
  • HY-149311
    PPO-IN-2

    		Protoporphyrinogen IX oxidase Others
    PPO-IN-2 is an inhibitor of protoporphyrinogen IX oxidase with an Ki of 16 nM .
    PPO-IN-2
  • HY-147901
    KDM1/CDK1-IN-1

    		Histone Demethylase CDK Apoptosis Caspase Cancer
    KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively .
    KDM1/CDK1-IN-1
  • HY-146239
    EGFR/HER2/TS-IN-2

    		EGFR Thymidylate Synthase Cancer
    EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM .
    EGFR/HER2/TS-IN-2
  • HY-W017355
    4-Hydroxythiobenzamide

    4-Hydroxybenzothioamide

    		 Drug Derivative Others
    4-Hydroxythiobenzamide (4-Hydroxybenzothioamide) (Compound HT), a benzothiazole derivative of Nootkatone (HY-N2195), serves as an intermediate .
    4-Hydroxythiobenzamide
  • HY-173263
    AChE-IN-86

    		Cholinesterase (ChE) Neurological Disease
    AChE-IN-86 (Compound 6f) is an inhibitor of enzyme acetylcholinesterase (AChE) with IC50 values of 25.33 μg/mL. AChE-IN-86 exerts inhibitory activity against AChE through forming hydrogen bonds, π-π and π-alkyl interactions with amino acid residues at the key catalytic sites of AChE. AChE-IN-86 can be used for Alzheimer's disease study .
    AChE-IN-86
  • HY-10862R
    FAAH inhibitor 1 (Standard)

    Benzothiazole analog 3 (Standard)

    		 Reference Standards FAAH Autophagy Neurological Disease Cancer
    FAAH inhibitor 1 (Standard) is the analytical standard of FAAH inhibitor 1 (HY-10862). This product is intended for research and analytical applications. FAAH inhibitor 1 (compound 3) is a selective reversible FAAH inhibitor. FAAH inhibitor 1 has no off-target activity with respect to other serine hydrolases. FAAH inhibitor 1 is exclusively specific against FAAH in rat brain with an IC50 value of 18 nM and had no missing protein bands in all the other tissues. FAAH inhibitor 1 can be used for neurological disorders research .
    FAAH inhibitor 1 (Standard)
  • HY-174454
    Antitrypanosomal agent 24

    		P-glycoprotein Infection
    Antitrypanosomal agent 24 is a benzothiazole amidoxime with strong and selective antitrypanosomal activity (IC50 = 0.92 μM). Antitrypanosomal agent 24 is a substrate of the P-glycoprotein efflux pump. Antitrypanosomal agent 24 has high membrane permeability and good metabolic stability. Antitrypanosomal agent 24 binds to DNA/RNA by intercalation .
    Antitrypanosomal agent 24
  • HY-179538
    CSH-4044

    		Biochemical Assay Reagents Pim DYRK Cancer
    CSH-4044 can be isolated from fermented wheat germ extract. CSH-4044 is a unique benzothiazole compound. CSH-4044 can inhibit PIM3-driven BAD phosphorylation in pancreatic cancer cell lines as well as reducing DYRK1A-induced Tau phosphorylation in neuronal cells .
    CSH-4044
  • HY-179708
    Cbz-QFR-kbt

    		Ser/Thr Protease Factor Xa SARS-CoV Influenza Virus Infection
    Cbz-QFR-kbt is a ketone-based benzothiazole ketone inhibitor of TMPRSS2, with an IC50 value of 0.42 nM. Cbz-QFR-kbt also has inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC50 values of 1, 1.3, 85, and 85 nM respectively. Cbz-QFR-kbt shows significant inhibitory effects against SARS-CoV-2 and H1N1 (IC50 = 60 nM). Cbz-QFR-kbt can be used in antiviral research .
    Cbz-QFR-kbt
  • HY-180976
    Arg-PEG1-Tαsyn

    		PROTACs α-synuclein Neurological Disease
    Arg-PEG1-Tαsyn is an α-syn PROTAC degrader with a DC50 of 0.28 μM in U251 cells. Arg-PEG1-Tαsyn employs the amino acid arginine (Arg) as the E3 ligase UBR1 ligand and a benzothiazole-aniline variant as the warhead for α-syn. Arg-PEG1-Tαsyn significantly reduces α-syn aggregates and improves the dopaminergic neuronal impairment and the locomotion with safety profile in vivo.Arg-PEG1-Tαsyn shows the high degradation effect in mammalian cells for both wild-type α-syn and the α-syn (A53T) mutant. Arg-PEG1-Tαsyn can be used for Parkinson’s disease research .
    Arg-PEG1-Tαsyn

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