2390-54-7
2390-54-7
Chemical Structure
Thioflavin T
Synonym(s): Basic Yellow 1
- CAS No.: 2390-54-7
- Formula:C17H19ClN2S
- Molecular Weight:318.86
IUPAC Name: 2-(4-(dimethylamino)phenyl)-3,6-dimethylbenzo[d]thiazol-3-ium chloride
InChIKey: JADVWWSKYZXRGX-UHFFFAOYSA-M
SMILES: CC1=CC=C2[N+](C)=C(C3=CC=C(N(C)C)C=C3)SC2=C1.[Cl-]
Biological Activity: Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Excitation max.: ~385 nm (free); ~450 nm (bound); Emission max.: ~445 nm (free); ~485 nm (bound)[1][2][3].
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Thioflavin T | 99.40% | Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Excitation max.: ~385 nm (free); ~450 nm (bound); Emission max.: ~445 nm (free); ~485 nm (bound). | ||||||||||||||||||||
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Thioflavin T (solution) | Thioflavin T (solution) is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Excitation max.: ~385 nm (free) ; ~450 nm (bound) ; Emission max.: ~445 nm (free) ; ~485 nm (bound) . Solvent and Concentration: Sterile water: 10 mM The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base. |
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References
- [1]. Khurana R, et al. Mechanism of thioflavin T binding to amyloid fibrils. J Struct Biol. 2005 Sep;151(3):229-38. [Content Brief]
- [2]. Nakano H, et al. Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation. Neurobiol Dis. 2025 Feb;205:106775. [Content Brief]
- [3]. Muramatsu D, et al. ALZ-801 prevents amyloid β-protein assembly and reduces cytotoxicity: A preclinical experimental study. FASEB J. 2025 Feb 15;39(3):e70382. [Content Brief]
