4-Amino-3-methoxybenzoic acid
Based on 1 Customer Validation
4-Amino-3-methoxybenzoic acid is a substituted aminobenzoic acid chemical intermediate. 4-Amino-3-methoxybenzoic acid also serves as a building block for the synthesis of acylurea derivatives in studies on human liver glycogen phosphorylase inhibitors. 4-Amino-3-methoxybenzoic acid can be used in organic synthesis and medicinal chemistry research.
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 2486-69-3
- Formula: C8H9NO3
- Molecular Weight:167.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
4-Amino-3-methoxybenzoic acid (compound 12) (0.05 M; 2-aminothiophenol: 0.053 M; PPA: 85 g; 220 °C; 4 h) serves as the acid component in PPA-mediated benzothiazole synthesis, yielding a mixture of 5 products[1].
4-Amino-3-methoxybenzoic acid reacts with the 2-chlorobenzoyl-derived intermediate to yield 4-[3-(2-chlorobenzoyl) ureido]-3-methoxybenzoic acid with a yield of 89%[2].
4-Amino-3-methoxybenzoic acid reacts with the 2,4-dichlorobenzoyl-derived intermediate to yield 4-[3-(2,4-dichlorobenzoyl) ureido]-3-methoxybenzoic acid with a yield of 99%[2].
4-Amino-3-methoxybenzoic acid reacts with the 2-fluorobenzoyl-derived intermediate to afford 4-[3-(2-fluorobenzoyl) ureido]-3-methoxybenzoic acid in a yield of 98%[2].
4-Amino-3-methoxybenzoic acid reacts with the 2-chloro-4-fluorobenzoyl-derived intermediate to afford 4-[3-(2-chloro-4-fluorobenzoyl) ureido]-3-methoxybenzoic acid with a yield of 97%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2486-69-3
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Appearance Solid
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Molecular Weight 167.16
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Formula C8H9NO3
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Color Light yellow to brown
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SMILES
O=C(O)C(C=C1OC)=CC=C1N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 25 mg/mL (149.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (298 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Shi DF, et al. Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. Journal of medicinal chemistry. 1996 Aug 16;39(17):3375-84. [Content Brief]
[2]. Klabunde T, et al. Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Journal of medicinal chemistry. 2005 Oct 06;48(20):6178-93. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.9823 mL | 29.9115 mL | 59.8229 mL | 149.5573 mL |
| 5 mM | 1.1965 mL | 5.9823 mL | 11.9646 mL | 29.9115 mL | |
| 10 mM | 0.5982 mL | 2.9911 mL | 5.9823 mL | 14.9557 mL | |
| 15 mM | 0.3988 mL | 1.9941 mL | 3.9882 mL | 9.9705 mL | |
| 20 mM | 0.2991 mL | 1.4956 mL | 2.9911 mL | 7.4779 mL | |
| 25 mM | 0.2393 mL | 1.1965 mL | 2.3929 mL | 5.9823 mL | |
| 30 mM | 0.1994 mL | 0.9970 mL | 1.9941 mL | 4.9852 mL | |
| 40 mM | 0.1496 mL | 0.7478 mL | 1.4956 mL | 3.7389 mL | |
| 50 mM | 0.1196 mL | 0.5982 mL | 1.1965 mL | 2.9911 mL | |
| 60 mM | 0.0997 mL | 0.4985 mL | 0.9970 mL | 2.4926 mL | |
| 80 mM | 0.0748 mL | 0.3739 mL | 0.7478 mL | 1.8695 mL | |
| 100 mM | 0.0598 mL | 0.2991 mL | 0.5982 mL | 1.4956 mL |
4-Amino-3-methoxybenzoic acid Related Classifications
HY-75577 Related Classifications
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