Search Result

Isoforms Recommended:	Chk2

Results for "

CHK2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Checkpoint Kinase (Chk) (43) 5-HT Receptor (1) Amyloid-β (2) Apoptosis (18) Aryl Hydrocarbon Receptor (1) ATM/ATR (4) Aurora Kinase (2) Autophagy (1) Bcl-2 Family (2) c-Fms (2) Calmodulin (2) Casein Kinase (1) Caspase (2) CDK (5) Choline Kinase (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (4) E1/E2/E3 Enzyme (1) ERK (1) FGFR (2) FLT3 (3) Histamine Receptor (1) Isotope-Labeled Compounds (1) MAP3K (2) MAPKAPK2 (MK2) (2) MDM-2/p53 (1) MEK (1) Microtubule‐associated serine/threonine kinase (MAST) (1) Mitosis (1) p38 MAPK (1) PARP (2) Phosphatase (2) PIN1 (1) PKC (1) Polo-like Kinase (PLK) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) RET (2) Small Interfering RNA (siRNA) (3) Src (2) STAT (1) VEGFR (3)
By Research Areas:	Cancer (48) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Checkpoint Kinase (Chk)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18174

Prexasertib Maximum Cited Publications 33 Publications Verification LY2606368	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity ^[2].

HY-13946

BML-277 5+ Cited Publications CHK2 Inhibitor II	Checkpoint Kinase (Chk) Apoptosis	Cancer
BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor with an IC₅₀ of 15 nM.

HY-15532

SCH900776 10+ Cited Publications MK-8776	Checkpoint Kinase (Chk)	Cancer
SCH900776 (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC₅₀ of 3 nM. SCH900776 shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively ^[2].

HY-14715B

CCT241533 hydrochloride 5+ Cited Publications	Checkpoint Kinase (Chk)	Cancer
CCT241533 hydrochloride is a potent and selective *CHK2* inhibitor with an IC₅₀ of 3 nM and a K_i of 1.16 nM .

HY-10032

PF 477736 4 Publications Verification PF 00477736	Checkpoint Kinase (Chk) VEGFR Src c-Fms Aurora Kinase FGFR FLT3 RET CDK	Cancer
PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of *Chk1, with a K_i* of 0.49 nM, it is also a *Chk2* inhibitor, with a K_i of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over *VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret* (IC₅₀=8 (K_i), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo ^[2].

HY-18174A

Prexasertib dihydrochloride Maximum Cited Publications 33 Publications Verification LY2606368 dihydrochloride	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib dihydrochloride inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity ^[2].

HY-B1165

Cyproheptadine (hydrochloride sesquihydrate) 3 Publications Verification	p38 MAPK Checkpoint Kinase (Chk) Histamine Receptor 5-HT Receptor CDK PARP Apoptosis	Cancer
Cyproheptadine hydrochloride sesquihydrate acts as a p38 MAP kinase activator, *CHK2* activator, histamine H1 receptor inhibitor and serotonin receptor inhibitor. Cyproheptadine hydrochloride sesquihydrate mediates cell cycle arrest via G1 phase arrest, G1/S transition arrest, G0/G1 phase arrest, reduced expression of cyclins *D1/D2/D3, upregulated expression of HBP1, p16, p21, p27, and decreased phosphorylation of retinoblastoma protein. Cyproheptadine hydrochloride sesquihydrate induces Apoptosis* by increasing PARP and cleaved PARP, as well as activating the mitochondrial caspase pathway. Cyproheptadine hydrochloride sesquihydrate inhibits tumor growth with extremely low toxicity to normal cells. Cyproheptadine hydrochloride sesquihydrate can be used in research related to hepatocellular carcinoma, multiple myeloma and acute myeloid leukemia ^[2].

HY-125203

PV-1019 2 Publications Verification NSC 744039	Checkpoint Kinase (Chk)	Cancer
PV-1019 (NSC 744039) is a potent, selective *Chk2* inhibitor with an IC₅₀ value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768)-induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis .

HY-117693

(E/Z)-Mirin 5+ Cited Publications	ATM/ATR	Cancer
(E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity ^[2].

HY-18174E

Prexasertib dimesylate Maximum Cited Publications 33 Publications Verification LY2606368 dimesylate	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity ^[2].

HY-153857

Lasmotinib PHI-101	FLT3 Checkpoint Kinase (Chk)	Cancer
Lasmotinib (PHI-101) is a FLT3 and *CHK2* inhibitor. Lasmotinib potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. Lasmotinib synergizes with Venetoclax (HY-15531) or Azacytidine to inhibit leukemia. Lasmotinib exhibits anticancer activity against ovarian and breast cancer ^[2] .

HY-103241

Ro 90-7501 3 Publications Verification	Amyloid-β ATM/ATR Phosphatase Apoptosis	Neurological Disease Cancer
Ro 90-7501 is an amyloid β₄₂ (Aβ₄₂) fibril assembly inhibitor that reduces Aβ₄₂-induced cytotoxicity (EC₅₀ of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response ^[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .

HY-100195

SAR-020106 1 Publications Verification	Checkpoint Kinase (Chk)	Cancer
SAR-020106 is an ATP-competitive, potent, and selective *CHK1* inhibitor with an IC₅₀ of 13.3 nM for human CHK1. SAR-020106 shows excellent selectivity over CHK2. SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion. SAR-020106 can enhance antitumor activity with selected anticancer agents ^[2].

HY-15883

GNE-900	Checkpoint Kinase (Chk) Apoptosis	Cancer
GNE-900 is a an ATP-competitive, selective, and orally active *ChK1* inhibitor with IC₅₀s of 0.0011, 1.5 μM for ChKl, ChK2, respectively. GNE-900 abrogates the G2-M checkpoint, enhances DNA damage, and induces Apoptosis. Gemcitabine (HY-17026) and GNE-900 administration shows anti-tumor activity .

HY-16129

CBP-501	Calmodulin Checkpoint Kinase (Chk) MAPKAPK2 (MK2) MAP3K	Cancer
CBP-501, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser ²¹⁶-specific kinases, such as *MAPKAP-K2, C-Tak1, CHK1* and *CHK2*, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 is used for various types of cancer ^[2].

HY-117102

ANI-7	Aryl Hydrocarbon Receptor Checkpoint Kinase (Chk)	Cancer
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI₅₀ of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines ^[2] .

HY-14715

CCT241533	Checkpoint Kinase (Chk)	Cancer
CCT241533 is a potent and selective ATP competitive inhibitor of *CHK2* with an IC₅₀ of 3 nM and K_i of 1.16 nM .

HY-14429

(-)-Irofulven 1 Publications Verification MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863	DNA Alkylator/Crosslinker Apoptosis	Cancer
(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity ^[2].

HY-112477

Chk2-IN-1 Hymenialdisine analogue-1	Checkpoint Kinase (Chk) Choline Kinase	Cancer
Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC₅₀s of 13.5 nM and 220.4 nM for *Chk2* and *Chk1, respectively. Chk2-IN-1* can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect .

HY-P5961

Chktide	Checkpoint Kinase (Chk)	Cancer
Chktide is a substrate for CHK1 and CHK2. Chktide can be used in kinase assays ^[2].

HY-18174H

Prexasertib lactate LY2606368 lactate	Checkpoint Kinase (Chk) Apoptosis DNA/RNA Synthesis	Cancer
Prexasertib lactate (LY2606368 lactate) is the lactate form of Prexasertib (HY-18174). Prexasertib lactate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib lactate inhibits *CHK2* (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib lactate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib lactate shows potent anti-tumor activity ^[2].

HY-106009

VRX0466617	Checkpoint Kinase (Chk)	Cancer
VRX0466617 is a selective and ATP-competitive *Chk2* inhibitor with an IC₅₀ of 120 nM and a K_i of 11 nM. VRX0466617 does not inhibit the related Chk1 activity. VRX0466617 can be used in the study of cancer.

HY-164523

PV1162	Checkpoint Kinase (Chk)	Cancer
PV1162 is a selective *Chk2* inhibitor with an IC₅₀ of 0.29 nM. PV1162 inhibits ATP binding to *Chk2* by targeting the gatekeeper-dependent hydrophobic pocket, which is specific to *Chk2* and located behind the ATP-binding site (adenine-binding region), thereby inhibiting the phosphorylation activity of *Chk2*. PV1162 holds potential application value in the field of cancer therapy .

HY-110331

CCT241533 dihydrochloride	Checkpoint Kinase (Chk)	Cancer
CCT241533 dihydrochloride is a potent and selective ATP competitive inhibitor of *CHK2* with an IC₅₀ of 3 nM and K_i of 1.16 nM .

HY-158303

Chk2-IN-2	Checkpoint Kinase (Chk)	Cancer
Chk2-IN-2 (compound 2) is a selective inhibitor of CHK2 with potential anticancer activity .

HY-18942

VER-00158411	Checkpoint Kinase (Chk)	Cancer
VER-00158411 is a checkpoint kinase 1 (CHK1) and *CHK2* inhibitor with IC₅₀ values of 4.4 nM and 4.5 nM, respectively .

HY-156916

ST045945	Microtubule‐associated serine/threonine kinase (MAST)	Metabolic Disease
WAY-230563 (ST045945) is a serine/threonine kinase inhibitor that can block CHK1/CHK2-mediated cell cycle checkpoints. WAY-230563 can induce G2/M phase arrest and DNA damage in tumor cells .

HY-124122

BPTQ	VEGFR Checkpoint Kinase (Chk) Apoptosis Caspase Bcl-2 Family	Cancer
BPTQ is a potent inhibitor against VEGFR1 and *CHK2* with IC₅₀ values of 0.54 and 1.70 µmol/L, respectively. BPTQ is also an intercalator of DNA with anticancer activities. BPTQ inhibits the proliferation of HL-60 cells by arresting cells at S and G2/M phase with an IC₅₀ value of 12 µmol/L. BPTQ also activates the mitochondria-mediated Apoptosis pathway by a decrease in mitochondrial membrane potential, increase in the Bax:Bcl-2 ratio and activation of caspases ^[2].

HY-119699

PV1115	Checkpoint Kinase (Chk)	Cancer
PV1115 is a potent and highly selective *Chk2* inhibitor with an IC₅₀ of 0.14 nM, 66000 nM, >100000 nM for Chk2, Chk1 and RSK2, respectively. PV1115 is situated within the ATP-binding pocket of Chk2 .

HY-124774

XL-844 EXEL-9844	Checkpoint Kinase (Chk)	Cancer
XL-844 (EXEL-9844) is an inhibitor of **Chk1 and Chk2**. XL-844 exhibits antineoplastic activity. XL-844 can result in tumor cell apoptosis through inhibition of cell cycle arrest. XL-844 inhibits VEGFR1 and VEGFR3. XL-844 can be studied in anti-cancer research .

HY-18174B

Prexasertib Mesylate Hydrate LY2606368 Mesylate Hydrate; LY2940930	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib Mesylate Hydrate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib Mesylate Hydrate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib Mesylate Hydrate shows potent anti-tumor activity ^[2].

HY-18174C

Prexasertib mesylate LY2606368 mesylate	Checkpoint Kinase (Chk) DNA/RNA Synthesis Apoptosis	Cancer
Prexasertib mesylate (LY2606368 mesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib mesylate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib mesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib mesylate shows potent anti-tumor activity ^[2].

HY-125010

Dicycloplatin	DNA/RNA Synthesis Apoptosis	Cancer
Dicycloplatin is a DNA damage inducer. Dicycloplatin induces DNA damage by activating biphosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1) and triphosphorylated p53. Dicycloplatin can induce cell cycle arrest, inhibit proliferation and lead to apoptosis in prostate cancer PC3 cells and lung cancer NCI/H446 cells. Dicycloplatin can be used in cancer researchr .

HY-P10574

Phosphorylated CHKtide	Checkpoint Kinase (Chk)	Cancer
Phosphorylated CHKtide is a synthetic peptide substrate derived from CDC25C, which is phosphorylated by *CHK1/CHK2* in one of the DNA repair pathways. Phosphorylated CHKtide is used in the assays of cell cycle checkpoint kinases 1 and 2 (CHK1/CHK2) and salt-inducible kinases (SIKs) .

HY-16129A

CBP-501 acetate	Calmodulin MAP3K MAPKAPK2 (MK2) Checkpoint Kinase (Chk)	Cancer
CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser ²¹⁶-specific kinases, such as *MAPKAP-K2, C-Tak1, CHK1* and *CHK2*, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer ^[2].

HY-103366

NSC 109555 ditosylate	Checkpoint Kinase (Chk)	Cancer
NSC 109555 ditosylate is a potent, selective, ATP-competitive checkpoint kinase 2 (Chk2) inhibitor with an IC₅₀ of 240 nM. NSC 109555 ditosylate can be used for the research of cancer .

HY-123597

NSC 109555 DDUG; NCI C04808	Autophagy Checkpoint Kinase (Chk)	Cancer
NSC 109555 is an ATP-competitive inhibitor of checkpoint kinase 2 (Chk2; IC₅₀=200 nM in a cell-free kinase assay). It is selective for Chk2 over Chk1 and 16 kinases in a panel but does inhibit Brk, c-Met, IGFR, and LCK with IC₅₀ values of 210, 6,000, 7,400, and 7,100 nM, respectively. NSC 109555 inhibits Chk2 autophosphorylation and phosphorylation of the Chk2 substrate histone H1 in vitro (IC₅₀=240 nM). It inhibits the growth of, and induces autophagy in, L1210 leukemia cells in vitro.2 NSC 109555 (1,250 nM) potentiates gemcitabine-induced cytotoxicity in MIA PaCa-2, CFPAC-1, PANC-1, and BxPC-3 pancreatic cancer cells, as well as reduces gemcitabine-induced increases in Chk2 phosphorylation and enhances gemcitabine-induced production of reactive oxygen species (ROS) in MIA PaCa-2 cells.

HY-U00345

CHK-IN-1	Checkpoint Kinase (Chk)	Cancer
CHK-IN-1 is an inhibitor of *CHK1* and *CHK2*, with anti-proliferative activities.

HY-157954

WRN inhibitor 6	DNA/RNA Synthesis Apoptosis	Cancer
WRN inhibitor 6 (compound 3ci) is a potent WRN inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression .

HY-112477A

*(E/Z)-Chk2-IN-1* (E/Z)-Hymenialdisine analogue-1	Checkpoint Kinase (Chk) Casein Kinase MEK PKC	Cancer
(E/Z)-Chk2-IN-1 ((E/Z)-Hymenialdisine analogue-1) (Compound 1) is a potent and selective cell cycle kinase Chk2 inhibitor with an IC₅₀ of 8 nM. (E/Z)-Chk2-IN-1 exhibits low inhibitory activity against other kinases (such as CK1δ, MEK1, and PKCα/βⅡ) with IC₅₀ values both >89 nM. (E/Z)-Chk2-IN-1 can be used for the research of cancer .

HY-128766A

CHK1-IN-4 hydrochloride	Checkpoint Kinase (Chk)	Cancer
CHK1-IN-4 hydrochloride is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC₅₀ ≤ 1 nM. The IC₅₀ value of CHK1-IN-4 hydrochloride against Chk2 ranges from 50 to 100 nM. CHK1-IN-4 hydrochloride inhibits cancer cell proliferation and exhibits antitumor activity in colon cancer xenograft models. CHK1-IN-4 hydrochloride can be used for the research of colon cancer and breast cancer .

HY-128766

CHK1-IN-4	Checkpoint Kinase (Chk)	Cancer
CHK1-IN-4 is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC₅₀ ≤ 1 nM. The IC₅₀ value of CHK1-IN-4 against Chk2 ranges from 50 to 100 nM. CHK1-IN-4 inhibits cancer cell proliferation and exhibits antitumor activity in colon cancer xenograft models. CHK1-IN-4 can be used for the research of colon cancer and breast cancer .

HY-18174S

Prexasertib-d4 LY2606368-d₄	Isotope-Labeled Compounds Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib-d₄ (LY2606368-d₄) is the deuterium labeled Prexasertib (HY-18174). Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity ^[2].

HY-12135

Poloxipan	Polo-like Kinase (PLK) PIN1 STAT	Cancer
Poloxipan is a pan-specific polo-like kinase (PLK) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain (PBD) found in kinases. The IC₅₀ values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 μM, 1.7 μM, and 3.0 μM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of *CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase (PIN1), and the phospho-tyrosine binding domains of STAT1/3/5* and lymphocyte-specific protein tyrosine kinase's SH2 domain. Poloxipan can be used in cancer research .

HY-10032R

PF 477736 (Standard) PF 00477736 (Standard)	Checkpoint Kinase (Chk) Reference Standards VEGFR Src c-Fms Aurora Kinase FGFR FLT3 RET CDK	Cancer
PF 477736 (Standard) is the analytical standard of PF 477736 (HY-10032). This product is intended for research and analytical applications. PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo ^[2].

HY-RS02621

Chek2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Checkpoint Kinase (Chk)	Others
Chek2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Chek2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Chek2 Rat Pre-designed siRNA Set A Chek2 Rat Pre-designed siRNA Set A

HY-N18301

Americanin A	ATM/ATR Checkpoint Kinase (Chk) MDM-2/p53 E1/E2/E3 Enzyme CDK Mitosis Reactive Oxygen Species (ROS) Apoptosis	Cancer
Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana. Americanin A activates ATM and ATR, initiating the subsequent signal transduction cascades that include Chk1, *Chk2, and tumor suppressor p53. Americanin A targets selectively Skp2* for degradation and thereby stabilizes p27. Americanin A suppresses the activity of Cyclin B1 and its partner *cdc2* to prevent entry into Mitosis. Americanin A induces Apoptosis by producing excessive ROS. Americanin A has anti-cancer activity against colorectal cancer .

HY-RS02620

Chek2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Checkpoint Kinase (Chk)	Others
Chek2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chek2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Chek2 Mouse Pre-designed siRNA Set A Chek2 Mouse Pre-designed siRNA Set A

HY-RS02619

CHEK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Checkpoint Kinase (Chk)	Others
CHEK2 Human Pre-designed siRNA Set A contains three designed siRNAs for CHEK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CHEK2 Human Pre-designed siRNA Set A CHEK2 Human Pre-designed siRNA Set A

HY-103241R

Ro 90-7501 (Standard)	Reference Standards Amyloid-β ATM/ATR Phosphatase Apoptosis	Neurological Disease Cancer
Ro 90-7501 (Standard) is the analytical standard of Ro 90-7501 (HY-103241). This product is intended for research and analytical applications. Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC₅₀ of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response ^[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .

Cat. No.	Product Name	Target	Research Area

HY-16129

CBP-501	Calmodulin Checkpoint Kinase (Chk) MAPKAPK2 (MK2) MAP3K	Cancer
CBP-501, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser ²¹⁶-specific kinases, such as *MAPKAP-K2, C-Tak1, CHK1* and *CHK2*, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 is used for various types of cancer ^[2].

HY-P5961

Chktide	Checkpoint Kinase (Chk)	Cancer
Chktide is a substrate for CHK1 and CHK2. Chktide can be used in kinase assays ^[2].

HY-P10574

Phosphorylated CHKtide	Checkpoint Kinase (Chk)	Cancer
Phosphorylated CHKtide is a synthetic peptide substrate derived from CDC25C, which is phosphorylated by *CHK1/CHK2* in one of the DNA repair pathways. Phosphorylated CHKtide is used in the assays of cell cycle checkpoint kinases 1 and 2 (CHK1/CHK2) and salt-inducible kinases (SIKs) .

HY-16129A

CBP-501 acetate	Calmodulin MAP3K MAPKAPK2 (MK2) Checkpoint Kinase (Chk)	Cancer
CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser ²¹⁶-specific kinases, such as *MAPKAP-K2, C-Tak1, CHK1* and *CHK2*, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer ^[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N18301

Americanin A	Structural Classification Monophenols Phenols Plants Phytolacca americana L. Phytolaccaceae Source Classification	ATM/ATR Checkpoint Kinase (Chk) MDM-2/p53 E1/E2/E3 Enzyme CDK Mitosis Reactive Oxygen Species (ROS) Apoptosis
Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana. Americanin A activates ATM and ATR, initiating the subsequent signal transduction cascades that include Chk1, *Chk2, and tumor suppressor p53. Americanin A targets selectively Skp2* for degradation and thereby stabilizes p27. Americanin A suppresses the activity of Cyclin B1 and its partner *cdc2* to prevent entry into Mitosis. Americanin A induces Apoptosis by producing excessive ROS. Americanin A has anti-cancer activity against colorectal cancer .

HY-167237

Calactin	Apocynaceae Asclepias curassavica L. Triterpenes Structural Classification Terpenoids Plants Source Classification	Apoptosis Caspase CDK PARP Bcl-2 Family ERK
Calactin is a glycoside that can be isolated from Asclepias curassavica L.. Calactin activates caspase-3, caspase-8, caspase-9, and phosphorylates ERK. Calactin induces DNA damage, apoptosis, PARP cleavage, G2/M phase cell cycle arrest, shifts *Bax/Bcl-2* expression, and shows anti-proliferation effects in leukemia cells. Calactin can be used for the research of leukemia .

Recombinant Proteins Recommended:

Species:	Human (3) Mouse (1)
Tag:	His (3) Strep (2) GST (4)
Source:	sf9 insect cells (2) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75349

	CHEK2 Protein, Human (Active, sf9, GST) Serine/threonine-protein kinase CHK2; Hucds1; Checkpoint kinase 2; CDS1; CHK2; RAD53	Human	Sf9 insect cells
	The CHEK2 protein is a serine/threonine protein kinase that critically coordinates checkpoint-mediated cell cycle arrest, DNA repair activation, and apoptosis in response to DNA double-strand breaks. Activated CHEK2 phosphorylates CDC25A, CDC25B, and CDC25C, inhibiting their phosphatase activities and preventing the CDK-cyclin complex from activating cell cycle progression. CHEK2 Protein, Human (sf9, GST) is the recombinant human-derived CHEK2 protein, expressed by Sf9 insect cells , with GST labeled tag.

HY-P75348

	CHEK2 Protein, Mouse (sf9, His-GST) Serine/threonine-protein kinase CHK2; Hucds1; Checkpoint kinase 2; CDS1; CHK2; RAD53	Mouse	Sf9 insect cells
	CHEK2 is a serine/threonine protein kinase that coordinates cellular responses to DNA double-strand breaks by activating cell cycle arrest, DNA repair, and apoptosis. It phosphorylates effectors and inhibits CDC25A, CDC25B, and CDC25C, thereby enhancing CDK cyclin inhibition and cell cycle arrest. CHEK2 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CHEK2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P705759

	CHEK2 Protein, Human (Active, I157T, sf9, His-GST, Strep) Serine/threonine-protein kinase CHK2; Hucds1; Checkpoint kinase 2; CDS1; CHK2; RAD53	Human	sf9 insect cells

HY-P705760

	CHEK2 Protein, Human (Active, R145W, sf9, His-GST, Strep) Serine/threonine-protein kinase CHK2; Hucds1; Checkpoint kinase 2; CDS1; CHK2; RAD53	Human	sf9 insect cells

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-18174S

Prexasertib-d4

Prexasertib-d₄ (LY2606368-d₄) is the deuterium labeled Prexasertib (HY-18174). Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity ^[2].

Host:	Mouse (2) Rabbit (5)
Reactivity:	Human (7) Rat (3) Mouse (4)
Application:	IHC-P (7) ICC/IF (7) IP (4) WB (7) ELISA (5)
Isotype:	IgG,Kappa (1) IgG (3) IgG, Kappa (1) IgG2b (2)
Conjugation:	Non-conjugated (7)
Clonality:	Polyclonal (1) Monoclonal (4) Monoclonal Antibody (1) Recombinant (3)
Modification:	Phosphorylated (2) Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86494

	Chk2 Antibody (YA6186) CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase CHK2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Chk2 Antibody (YA6186) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Chk2.

HY-P80083

	Chk2 Antibody (YA504)	WB, ICC/IF, IHC-P, IP	Human
	Chk2 Antibody (YA504) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Chk2.

HY-P87898

	Chk2 Antibody (YA7583)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse
	Chk2 Antibody (YA7583) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Chk2.

HY-P80799

	*Phospho-Chk2* (Thr68) Antibody** 2 Publications Verification CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase CHK2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Phospho-Chk2 (Thr68) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-Chk2 (Thr68).

HY-P83884

	CHK2 Antibody (YA3581) CDS1; LFS2; CHEK2	WB, IHC-P, ICC/IF, ELISA	Human
	CHK2 Antibody (YA3581) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CHK2.

HY-P83884A

	CHK2 Antibody (YA3581)(PBS only) CDS1; LFS2; CHEK2	WB, IHC-P, ICC/IF, ELISA	Human
	CHK2 Antibody (YA3581) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CHK2.

HY-P87725

	*Phospho-Chk2* (Thr68) Antibody (YA7410)**	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-Chk2 (Thr68) Antibody (YA7410) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-Chk2 (Thr68).