2127107-15-5

Lasmotinib Chemical Structure
2127107-15-5

Chemical Structure

Lasmotinib

Synonym(s): PHI-101

  • CAS No.: 2127107-15-5
  • Formula:C19H19FN4O2S
  • Molecular Weight:386.44

InChIKey: ULVAGWVTXBTFRN-AWEZNQCLSA-N

SMILES: NC(NC1=C(SC(C#CC2=CC(F)=CC=C2)=C1)C(N[C@H]3CCCNC3)=O)=O

Biological Activity: Lasmotinib (PHI-101) is a FLT3 and CHK2 inhibitor. Lasmotinib potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. Lasmotinib synergizes with Venetoclax (HY-15531) or Azacytidine to inhibit leukemia. Lasmotinib exhibits anticancer activity against ovarian and breast cancer[1][2][3][4].

Cat. No. Nom du produit Pureté Description Pricing
HY-153857 		Lasmotinib 98.16% Lasmotinib (PHI-101) is a FLT3 and CHK2 inhibitor. Lasmotinib potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. Lasmotinib synergizes with Venetoclax (HY-15531) or Azacytidine to inhibit leukemia. Lasmotinib exhibits anticancer activity against ovarian and breast cancer.
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