1 Result for "

CUR5g

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "CUR5g" in MCE Product Catalog:

Cat. No.: HY-152100
CAS No.: 1370032-20-4
Purity:  98.69%
Target:  

Autophagy

Research Areas:  

Cancer

CUR5g is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g improves the anticancer effect of Cisplatin (HY-17394) against A549 cells both in vitro and in vivo .
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