1370032-20-4
Chemical Structure
CUR5g
- CAS No.: 1370032-20-4
- Formula:C22H20N2O2
- Molecular Weight:344.41
IUPAC Name: (E)-3-((1H-indol-3-yl)methylene)-5-((E)-4-hydroxybenzylidene)-1-methylpiperidin-4-one
InChIKey: JMVVTYLZZDOERS-ODPUSEOTSA-N
SMILES: O=C1/C(CN(C)C/C1=C\C2=CNC3=C2C=CC=C3)=C/C4=CC=C(O)C=C4
Biological Activity: CUR5g is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g improves the anticancer effect of Cisplatin (HY-17394) against A549 cells both in vitro and in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CUR5g | 98.69% | CUR5g is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g improves the anticancer effect of Cisplatin (HY-17394) against A549 cells both in vitro and in vivo. | ||||||||||||||||||||
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