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Results for "

CXCR7/ACKR3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CXCR (5) Arrestin (2) Fluorescent Dye (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (2) Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Recombinant Proteins

Targets Recommended: CXCR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123813

CCX-777	CXCR Arrestin	Cancer
CCX-777 is an orthosteric binder and partial agonist of *CXCR7/ACKR3. CCX-777 induces the recruitment of β-arrestin 2* and affects the rebinding of chemokines to ACKR3. CCX-777 functions to stabilize the ACKR3 receptor and promotes the formation of a monodisperse, stable complex of the receptor in DDM/CHS micelles. CCX-777 is widely used in cancer-related research ^[3] .

HY-P10333A

LIH383 TFA	CXCR	Neurological Disease Inflammation/Immunology
LIH383 TFA is an agonist of **ACKR3 (CXCR7) (EC₅₀*=0.61 nM). LIH383 TFA efficiently induces the recruitment of β-arrestin to ACKR3* but does not trigger typical G protein signaling .

HY-P10333

LIH383	CXCR	Neurological Disease Inflammation/Immunology
LIH383 is an agonist of **ACKR3 (CXCR7) (EC₅₀*=0.61 nM). LIH383 efficiently induces the recruitment of β-arrestin to ACKR3* but does not trigger typical G protein signaling .

HY-182533

LN5972	CXCR	Cardiovascular Disease
LN5972 is a selective *ACKR3* agonist with an EC₅₀ of 3.40 μM, showing higher selectivity for *ACKR3* over *CXCR4. LN5972 induces β-arrestin recruitment to ACKR3/CXCR7. LN5972 reduces the surface expression of P-selectin*. LN5972 is applicable to studies related to platelet-mediated thrombosis .

HY-123813A

CCX-777 formic	CXCR Arrestin	Cancer
CCX-777 formic is an orthosteric binder and partial agonist of *CXCR7/ACKR3. CCX-777 formic induces the recruitment of β-arrestin 2* and affects the rebinding of chemokines to ACKR3. CCX-777 formic functions to stabilize the ACKR3 receptor and promotes the formation of a monodisperse, stable complex of the receptor in DDM/CHS micelles. CCX-777 formic is widely used in cancer-related research ^[3] .

HY-D2201

Fluorescent ACKR3 antagonist 1	Fluorescent Dye	Cancer
Fluorescent ACKR3 antagonist 1(compound 18a) is a atypical chemokine receptor 3 antagonist .

Fluorescent ACKR3 antagonist 1	Fluorescent Dyes
Fluorescent ACKR3 antagonist 1(compound 18a) is a atypical chemokine receptor 3 antagonist .

Cat. No.	Product Name	Target	Research Area

HY-P10333A

LIH383 TFA	CXCR	Neurological Disease Inflammation/Immunology
LIH383 TFA is an agonist of **ACKR3 (CXCR7) (EC₅₀*=0.61 nM). LIH383 TFA efficiently induces the recruitment of β-arrestin to ACKR3* but does not trigger typical G protein signaling .

HY-P10333

LIH383	CXCR	Neurological Disease Inflammation/Immunology
LIH383 is an agonist of **ACKR3 (CXCR7) (EC₅₀*=0.61 nM). LIH383 efficiently induces the recruitment of β-arrestin to ACKR3* but does not trigger typical G protein signaling .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700537

	ACKR3 Protein, Human (His-SUMO) RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159;	Human	E. coli
	ACKR3 is an atypical chemokine receptor that precisely controls chemokine levels and localization through high-affinity binding, operating independently of ligand-driven signaling. It acts as an interceptor, internalization receptor, and chemokine scavenger for CXCL11 and CXCL12/SDF1, inducing β-arrestin recruitment, ligand internalization, and MAPK pathway activation. ACKR3 Protein, Human (His-SUMO) is the recombinant human-derived ACKR3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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