1226686-36-7
Chemical Structure
CCX-777
- CAS No.: 1226686-36-7
- Formula:C31H43N7O3S
- Molecular Weight:593.78
IUPAC Name: 3-(4-(7-methoxyquinolin-8-yl)-1,4-diazepan-1-yl)-3-(2-morpholinothiazol-4-yl)-N-(2-(pyrrolidin-1-yl)ethyl)propanamide
InChIKey: PUPJAMOHYJWOKK-UHFFFAOYSA-N
SMILES: O=C(NCCN1CCCC1)CC(N2CCN(C3=C4N=CC=CC4=CC=C3OC)CCC2)C5=CSC(N6CCOCC6)=N5
Biological Activity: CCX-777 is an orthosteric binder and partial agonist of CXCR7/ACKR3. CCX-777 induces the recruitment of β-arrestin 2 and affects the rebinding of chemokines to ACKR3. CCX-777 functions to stabilize the ACKR3 receptor and promotes the formation of a monodisperse, stable complex of the receptor in DDM/CHS micelles. CCX-777 is widely used in cancer-related research[1][2][3][4].
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CCX-777 | 98.47% | CCX-777 is an orthosteric binder and partial agonist of CXCR7/ACKR3. CCX-777 induces the recruitment of β-arrestin 2 and affects the rebinding of chemokines to ACKR3. CCX-777 functions to stabilize the ACKR3 receptor and promotes the formation of a monodisperse, stable complex of the receptor in DDM/CHS micelles. CCX-777 is widely used in cancer-related research. | ||||||||||||||||||||
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References
- [1]. Santagata S, et al. CXCR4 and CXCR7 Signaling Pathways: A Focus on the Cross-Talk Between Cancer Cells and Tumor Microenvironment. Front Oncol. 2021;11:591386. Published 2021 Apr 15. [Content Brief]
- [2]. Gustavsson M, et al. Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N terminus in chemokine binding[J]. Science signaling, 2019, 12(598): eaaw3657.
- [3]. Lounsbury N. Advances in CXCR7 modulators[J]. Pharmaceuticals, 2020, 13(2): 33.
- [4]. Gustavsson M, et al. Structural basis of ligand interaction with atypical chemokine receptor 3. Nat Commun. 2017;8:14135. Published 2017 Jan 18. [Content Brief]
