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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
CaMKIIα-PHOTAC
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "CaMKIIα-PHOTAC" in MCE Product Catalog:
Cat. No.: HY-156104
CAS No.: 2481744-33-4
Research Areas:
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains .
Cat. No.: HY-175681
CAS No.: 1613270-82-8
Research Areas:
CaMKIIα ligand-1 is a photoactivatable CaMKIIα ligand that can be used for PROTAC synthesis. CaMKIIα ligand-1 serves as the target protein ligand for CaMKIIα-PHOTAC (HY-156104). CaMKIIα ligand-1 is applicable to research related to neurological diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
