9 Results for "

Caspase-11

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "Caspase-11" in MCE Product Catalog:

25
Wedelolactone
Wedelolactone
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25 Publications Verification
Cat. No.: HY-N0551
CAS No.: 524-12-9
Category:  

Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Caspase Lipoxygenase Apoptosis

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .
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12
Ac-FLTD-CMK
Ac-FLTD-CMK
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12 Cited Publications
Cat. No.: HY-111675
CAS No.: 2376255-48-8
Purity:  99.53%
Target:  

Caspase Pyroptosis

Research Areas:  

Inflammation/Immunology

Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3 .
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1
Caspase 11 Antibody (YA562)
Caspase 11 Antibody (YA562)
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1 Cited Publications
Cat. No.: HY-P80588
Synonyms: Caspl; ich-3; CASP-4; Casp11; CASP-11

Host:  

Rabbit

Application:  

WB, IP

Reactivity:  

Human, Mouse, Rat

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Phaseoloidin
Phaseoloidin
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Cat. No.: HY-N7400
CAS No.: 118555-82-1
Category:  

other families Monophenols Other Diseases Phenols Plants Disease Research Fields

Target:  

NOD-like Receptor (NLR) Caspase Autophagy Apoptosis AMPK mTOR Insecticide

Phaseoloidin is an orally active multi-target inhibitor. Phaseoloidin inhibits the activation of the NLRP3 inflammasome and blocks the caspase-11-GSDMD pyroptosis axis. Phaseoloidin reduces the expression of collagen-degrading enzymes to maintain the integrity of cartilage matrix. Phaseoloidin activates the AMPK/mTOR pathway to enhance autophagy function and reverse apoptosis resistance. Phaseoloidin inhibits the growth and development of Manduca sexta and Spodoptera littoralis larvae, thereby helping Nicotiana attenuata defend against lepidopteran herbivorous insects. Phaseoloidin can be used in research related to acute gouty arthritis and pulmonary fibrosis .
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1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine
1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine
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Cat. No.: HY-W040255
CAS No.: 89947-79-5
Synonyms: PGPC
1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is an oxidized phospholipid. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine reduces the viability of HUVECs, increases the levels of ferrous ions and lipid peroxidation, promotes the production of superoxide anions, and decreases the levels of glutathione and GPX4 in cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine upregulates the mRNA and protein levels of FABP3 in HUVECs, impairs mitochondrial membrane potential, and induces ferroptosis-related changes as well as mitochondrial dysfunction and damage. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine activates caspase-11 and promotes the continuous release of IL-1β from macrophages and dendritic cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibits the proliferation of aortic smooth muscle cells and induces apoptosis in these cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is applicable to relevant research on atherosclerosis .
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Wedelolactone (Standard)
Wedelolactone (Standard)
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Cat. No.: HY-N0551R
CAS No.: 524-12-9
Category:  

Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae

Target:  

Reference Standards Caspase Lipoxygenase Apoptosis

Wedelolactone (Standard) is the analytical standard of Wedelolactone. This product is intended for research and analytical applications. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .
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Caspase 11 Antibody (YA562)(PBS only)
Caspase 11 Antibody (YA562)(PBS only)
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Cat. No.: HY-P80588A
Synonyms: Caspl; ich-3; CASP-4; Casp11; CASP-11

Host:  

Rabbit

Application:  

WB, IP

Reactivity:  

Human, Mouse, Rat

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Ac-YEVD-AMC
Ac-YEVD-AMC
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Cat. No.: HY-P10142
CAS No.: 1631716-11-4
Target:  

Fluorescent Dye

Research Areas:  

Others

Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .
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CASP4 Antibody
CASP4 Antibody
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Cat. No.: HY-P81251
Synonyms: Caspase-4 subunit 2; Caspase-4 subunit p10; Caspase-11; CASP-11; Protease ICH-3; Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP 4; CASP-4; CASP4; CASP4_HUMAN; CASP4_MOUSE; Caspase 4 apoptosis related cysteine peptidase; Caspase-4 subunit 2; Caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; ICH 2 protease; ICH2; Mih1/TX; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease; EC:3.4.22.64.

Host:  

Rabbit

Application:  

WB, ELISA

Reactivity:  

Human, Rat

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