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Citrate lyase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ATP Citrate Lyase (17) Acetyl-CoA Carboxylase (1) AMPK (6) Apoptosis (2) Autophagy (1) Biochemical Assay Reagents (1) DNA/RNA Synthesis (2) Endogenous Metabolite (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (2) Free Fatty Acid Receptor (1) Keap1-Nrf2 (2) mTOR (2) NF-κB (2) Reference Standards (2) Ribosomal S6 Kinase (RSK) (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (16)

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Isotope-Labeled Compounds

Antibodies

Targets Recommended: ATP Citrate Lyase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16450

SB 204990 Maximum Cited Publications 25 Publications Verification	ATP Citrate Lyase	Metabolic Disease
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

HY-12357

Bempedoic acid 20+ Cited Publications ETC-1002; ESP-55016	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid (ETC-1002) is an *ATP-citrate* lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK** .

HY-16107

BMS-303141 20+ Cited Publications	ATP Citrate Lyase	Metabolic Disease
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 0.13 μM.

HY-N1437

Hydroxycitric acid 1 Publications Verification	Apoptosis Ferroptosis mTOR DNA/RNA Synthesis Keap1-Nrf2 Ribosomal S6 Kinase (RSK) NF-κB ATP Citrate Lyase AMPK	Cardiovascular Disease Metabolic Disease Cancer
Hydroxycitric acid is an orally active, multi-target, multi-bioactive organic acid. activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Hydroxycitric acid activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Hydroxycitric acid activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

HY-127111

NDI-091143 2 Publications Verification	ATP Citrate Lyase	Cancer
NDI-091143 is a potent and high-affinity *human ATP-citrate* lyase (ACLY) inhibitor with an IC₅₀ of 2.1 nM (ADP-Glo assay), a K_i of 7.0 nM and a K_d of 2.2 nM. NDI-091143 inhibits ACLY** catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate .

HY-175606

EVT0185	ATP Citrate Lyase	Cancer
EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC₅₀ of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increase tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC) .

HY-P1123

MEDICA16	ATP Citrate Lyase Free Fatty Acid Receptor Acetyl-CoA Carboxylase	Metabolic Disease
MEDICA16 is an orally active acetyl-CoA carboxylase and ATP-citrate lyase inhibitor. MEDICA16 limits the acetyl-CoA supply for acetyl-CoA carboxylase, inhibits acetyl-CoA carboxylase activity, exerts citrate-competitive inhibitory effects on ATP-citrate lyase, and reduces hepatic AMPK activity. MEDICA16 can be used in research related to insulin resistance, hyperlipidemia, and obesity .

HY-W338584

Hydroxycitric acid tripotassium 1 Publications Verification	Keap1-Nrf2 Ferroptosis Apoptosis mTOR NF-κB ATP Citrate Lyase AMPK Ribosomal S6 Kinase (RSK) DNA/RNA Synthesis	Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-17640

Nicodicosapent	Fatty Acid Synthase (FASN) Autophagy	Metabolic Disease
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

HY-172914

ACLY-IN-1	ATP Citrate Lyase	Cardiovascular Disease Metabolic Disease
ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity (IC₅₀ = 8.3 nM) and high binding affinity (K_D = 72.0 nM) to ACLY. ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect .

HY-12357S2

Bempedoic acid-d4 ETC-1002-d₄; ESP-55016-d₄	ATP Citrate Lyase AMPK	Others
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK .

HY-177136

ACLY-IN-2	ATP Citrate Lyase	Metabolic Disease Inflammation/Immunology Cancer
ACLY-IN-2 (Compound 7) has inhibitory effect against *human ATP citrate* lyase (hACLY), with an IC₅₀** of less than 1 nM. ACLY-IN-2 can be studied in research on liver-related diseases, type-2 diabetes, autoimmunity, and cancer .

HY-P2843

**Citrate lyase**	Endogenous Metabolite	Metabolic Disease
Citrate lyase is an enzyme that converts citrate to oxaloacetate .

HY-12357S

Bempedoic acid-d5 ETC-1002-d₅; ESP-55016-d₅	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid . Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

HY-12357R

Bempedoic acid (Standard) ETC-1002 (Standard); ESP-55016 (Standard)	ATP Citrate Lyase AMPK Reference Standards	Metabolic Disease
Bempedoic acid (Standard) is the analytical standard of Bempedoic acid. This product is intended for research and analytical applications. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

HY-N12336

Gnetuhainin I	Others	Metabolic Disease
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC₅₀=2.63 μM) .

HY-P2843A

Citrate Lyase, Klebsiella pneumoniae	Biochemical Assay Reagents	Metabolic Disease
Citrate Lyase, Klebsiella pneumoniae (EC 4.1.3.6) catalyzes the first step of Citrate degradation, forming acetate and oxaloacetate. Citrate Lyase, Klebsiella pneumoniae (EC 4.1.3.6) contains 3 polypeptide subunits, α-subunit (a transferase), β-subunit (acyl lyase) and γ-subunit (acyl-carrier protein).

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard) Garcinia lactone (Standard)	Reference Standards ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-182750

ACLY-IN-3	ATP Citrate Lyase	Inflammation/Immunology
ACLY-IN-3 is an ATP-citrate lyase (ACLY) inhibitor with an IC₅₀ of 0.036 μM and a target K_d of 0.54 μM. ACLY-IN-3 interacts with the allosteric binding site of ACLY to inhibit its activity. ACLY-IN-3 exhibits excellent lipid-lowering effects and alleviates hepatic inflammation and liver fibrosis. ACLY-IN-3 can be used for the research of metabolic dysfunction-associated steatohepatitis .

HY-182751

ACLY-IN-4	ATP Citrate Lyase	Inflammation/Immunology
ACLY-IN-4 is an ATP-citrate lyase (ACLY) inhibitor with an IC₅₀ of 0.022 μM and a K_d of 0.19 μM. ACLY-IN-4 binds to the allosteric binding site of ACLY. ACLY-IN-4 exhibits hypolipidemic, anti-steatotic, insulin sensitivity-improving, anti-oxidative stress, anti-inflammatory and anti-fibrotic activities. ACLY-IN-4 alleviates hepatic steatosis, systemic insulin resistance, oxidative stress, hepatic inflammation and fibrosis. ACLY-IN-4 can be used for the research of metabolic dysfunction-associated steatohepatitis .

Cat. No.	Product Name	Type

HY-W338584

Hydroxycitric acid tripotassium 1 Publications Verification	Biochemical Assay Reagents
Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

Hydroxycitric acid tripotassium

1 Publications Verification

Biochemical Assay Reagents

Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1437

Hydroxycitric acid 1 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Guttiferae Plants Garcinia gummi-gutta (L.) Roxb. Source Classification	Apoptosis Ferroptosis mTOR DNA/RNA Synthesis Keap1-Nrf2 Ribosomal S6 Kinase (RSK) NF-κB ATP Citrate Lyase AMPK
Hydroxycitric acid is an orally active, multi-target, multi-bioactive organic acid. activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Hydroxycitric acid activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Hydroxycitric acid activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	other families Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Plants Disease Research Fields Source Classification	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-N12336

Gnetuhainin I	Urticaceae Pouzolzia zeylanica (L.) Benn. Phenols Polyphenols Plants Source Classification	Others
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC₅₀=2.63 μM) .

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard) Garcinia lactone (Standard)	other families Ketones, Aldehydes, Acids Plants Source Classification	Reference Standards ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

Species:	Human (2)
Tag:	SUMO (1) His (2)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72070

	ACLY Protein, Human (His-SUMO) 1 Publications Verification ACL; Acly; ACLY_HUMAN; ATP Citrate pro-S; lyase; ATP Citrate lyase; ATP Citrate synthase; ATP-Citrate pro-S-; -lyase; ATP-Citrate synthase; ATPCitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773	Human	E. coli
	ACLY Protein, Human (His-SUMO) is an important enzyme in the cholesterol biosynthetic pathway. ACLY produces acetyl-CoA (AcCoA) from mitochondrial citrate for cholesterol and fatty acid biosynthesis.

HY-P705696

	ACLY Protein, Human (Sf9, His) ACL; Acly; ACLY_HUMAN; ATP Citrate pro-S; lyase; ATP Citrate lyase; ATP Citrate synthase; ATP-Citrate pro-S-; -lyase; ATP-Citrate synthase; ATPCitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773	Human	Sf9 insect cells
	ACLY Protein, Human (Sf9, His) is an important enzyme in the cholesterol biosynthetic pathway. ACLY produces acetyl-CoA (AcCoA) from mitochondrial citrate for cholesterol and fatty acid biosynthesis.

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Cat. No.	Product Name	Chemical Structure

HY-12357S2

Bempedoic acid-d4
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK .

HY-12357S

Bempedoic acid-d5
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid . Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

Host:	Mouse (4) Rabbit (4)
Reactivity:	Human (8) Rat (5) Mouse (8) Monkey (4) Rabbit (2)
Application:	IHC-P (5) ICC/IF (8) IP (3) WB (8) FC (5) ELISA (3)
Isotype:	IgG,Kappa (1) IgG (3) IgG1 (2) IgG2a (2)
Conjugation:	Non-conjugated (8)
Clonality:	Monoclonal (5) Monoclonal Antibody (1) Recombinant (4)
Modification:	Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80560

	*ATP Citrate* Lyase Antibody (YA829)** ACLY; ATP-Citrate synthase; ATP-Citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme	WB, ICC/IF, FC	Human, Mouse, Monkey
	ATP Citrate Lyase Antibody (YA829) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P80560A

	*ATP Citrate* Lyase Antibody (YA829)(PBS only)** ACLY; ATP-Citrate synthase; ATP-Citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme	WB, ICC/IF, FC	Human, Mouse, Monkey
	ATP Citrate Lyase Antibody (YA829) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P80380

	*ATP Citrate* Lyase Antibody (YA596)**	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	ATP Citrate Lyase Antibody (YA596) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P87887

	*ATP-Citrate* Lyase Antibody (YA7572)**	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ATP-Citrate Lyase Antibody (YA7572) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to ATP-Citrate Lyase.

HY-P84388

	*ATP Citrate* Lyase Antibody (YA4085)** ACL; ATPCL; CLATP	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
	ATP Citrate Lyase Antibody (YA4085) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P84388A

	*ATP Citrate* Lyase Antibody (YA4085)(PBS only)** ACL; ATPCL; CLATP	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
	ATP Citrate Lyase Antibody (YA4085) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P82406

	Aconitase 2 Antibody (YA2151) Aconitate hydratase; mitochondrial; Aconitase; Citrate hydro-lyase	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Aconitase 2 Antibody (YA2151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aconitase 2.

HY-P83105

	Aconitase 1 Antibody (YA2850) ACO1; IREB1; Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1	WB, ICC/IF	Human, Mouse, Rat
	Aconitase 1 Antibody (YA2850) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aconitase 1.

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Citrate lyase

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products