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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
Citrate lyase
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "Citrate lyase" in MCE Product Catalog:
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Citrate lyase is an enzyme that converts citrate to oxaloacetate .
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26 Publications Verification
Cat. No.: HY-16450
CAS No.: 154566-12-8
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SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
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23 Cited Publications
Synonyms: ETC-1002; ESP-55016
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Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .
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23 Cited Publications
Cat. No.: HY-16107
CAS No.: 943962-47-8
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BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
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2 Cited Publications
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NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate .
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1 Cited Publications
Cat. No.: HY-W338584
CAS No.: 232281-44-6
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Cat. No.: HY-175606
CAS No.: 2588489-03-4
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EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increase tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC) .
Cat. No.: HY-P1123
CAS No.: 87272-20-6
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MEDICA16 is an orally active acetyl-CoA carboxylase and ATP-citrate lyase inhibitor. MEDICA16 limits the acetyl-CoA supply for acetyl-CoA carboxylase, inhibits acetyl-CoA carboxylase activity, exerts citrate-competitive inhibitory effects on ATP-citrate lyase, and reduces hepatic AMPK activity. MEDICA16 can be used in research related to insulin resistance, hyperlipidemia, and obesity .
Cat. No.: HY-N7347
CAS No.: 27750-13-6
Synonyms: Garcinia lactone
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ESP15228 is a metabolite of Bempedoic acid (HY-12357). ESP15228 undergoes glucuronidation to form ESP15228-glucuronide. ESP15228 can form excretory ESP15228-taurine conjugate in feces. ESP15228-CoA is a selective hepatic ATP citrate lyase inhibitor. ESP15228 can be used in the research of hypercholesterolemia .
Cat. No.: HY-17640
CAS No.: 1269181-69-2
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Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
Cat. No.: HY-172914
CAS No.: 2897695-26-8
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ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity (IC50 = 8.3 nM) and high binding affinity (KD = 72.0 nM) to ACLY. ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect .
Synonyms: ETC-1002-d4; ESP-55016-d4
Cat. No.: HY-177136
CAS No.: 3009136-86-8
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ACLY-IN-2 (Compound 7) has inhibitory effect against human ATP citrate lyase (hACLY), with an IC50 of less than 1 nM. ACLY-IN-2 can be studied in research on liver-related diseases, type-2 diabetes, autoimmunity, and cancer .
Cat. No.: HY-12357S
CAS No.: 2408131-71-3
Synonyms: ETC-1002-d5; ESP-55016-d5
Cat. No.: HY-12357R
CAS No.: 738606-46-7
Synonyms: ETC-1002 (Standard); ESP-55016 (Standard)
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Bempedoic acid (Standard) is the analytical standard of Bempedoic acid. This product is intended for research and analytical applications. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .
Cat. No.: HY-N12336
CAS No.: 308105-06-8
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Cat. No.: HY-P2843A
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Citrate Lyase, Klebsiella pneumoniae (EC 4.1.3.6) catalyzes the first step of Citrate degradation, forming acetate and oxaloacetate. Citrate Lyase, Klebsiella pneumoniae (EC 4.1.3.6) contains 3 polypeptide subunits, α-subunit (a transferase), β-subunit (acyl lyase) and γ-subunit (acyl-carrier protein).
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
