413624-71-2
413624-71-2
Chemical Structure
ESP15228
- CAS No.: 413624-71-2
- Formula:C19H34O5
- Molecular Weight:342.47
IUPAC Name: 2,2,14,14-tetramethyl-8-oxopentadecanedioic acid
InChIKey: NHVXRVOYVVPVDU-UHFFFAOYSA-N
SMILES: O=C(O)C(C)(C)CCCCCC(CCCCCC(C)(C)C(O)=O)=O
Biological Activity: ESP15228 is a metabolite of Bempedoic acid (HY-12357). ESP15228 undergoes glucuronidation to form ESP15228-glucuronide. ESP15228 can form excretory ESP15228-taurine conjugate in feces. ESP15228-CoA is a selective hepatic ATP citrate lyase inhibitor. ESP15228 can be used in the research of hypercholesterolemia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ESP15228 | 98.0% | ESP15228 is a metabolite of Bempedoic acid (HY-12357). ESP15228 undergoes glucuronidation to form ESP15228-glucuronide. ESP15228 can form excretory ESP15228-taurine conjugate in feces. ESP15228-CoA is a selective hepatic ATP citrate lyase inhibitor. ESP15228 can be used in the research of hypercholesterolemia. | ||||||||||||||||||||
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Bempedoic acid impurity 1-d4 | 98.0% | Bempedoic acid impurity 1-d4 is the deuterium labeled Bempedoic acid impurity 1. | ||||||||||||||||||||
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References
- [1]. Amore BM, et al. The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects. Drug metabolism and disposition: the biological fate of chemicals. 2023 May;51(5):599-609. [Content Brief]
- [2]. Zampieri M, et al. X-ray powder diffraction data for ESP15228, C19H34O5, a bempedoic acid metabolite[J]. Powder Diffraction, 2023, 38(2): 158-160.
