6205-14-7
Chemical Structure
Hydroxycitric acid
- CAS No.: 6205-14-7
- Formula:C6H8O8
- Molecular Weight:208.12
IUPAC Name: 1,2-dihydroxypropane-1,2,3-tricarboxylic acid
InChIKey: ZMJBYMUCKBYSCP-UHFFFAOYSA-N
SMILES: OC(C(C(O)=O)O)(C(O)=O)CC(O)=O
Biological Activity: Hydroxycitric acid is an orally active, multi-target, multi-bioactive organic acid. activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Hydroxycitric acid activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Hydroxycitric acid activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation[1][2][3][4].
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Hydroxycitric acid | Hydroxycitric acid is an orally active, multi-target, multi-bioactive organic acid. activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Hydroxycitric acid activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Hydroxycitric acid activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation. | |||||||||||||||||||||
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Similarity Score 0.91
HY-1133712-Methylcitric acid -
Similarity Score 0.86
HY-N1428RCitric acid (standard) -
Similarity Score 0.86
HY-N1428S1Citric acid-13C6 -
Similarity Score 0.86
HY-N1428S2Citric acid-13C2 -
Similarity Score 0.86
HY-N1428S3Citric acid-13C3 -
Similarity Score 0.86
HY-W127841Citric acid-2,4-13C2 -
Similarity Score 0.85
HY-B1529ACitric acid triammonium -
Similarity Score 0.85
HY-B2201Citric acid trisodium -
Similarity Score 0.85
HY-N1428ACitric acid monohydrate -
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References
- [1]. Verrelli D, et al. Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway. Nutrients. 2022;14(13):2669. Published 2022 Jun 27. [Content Brief]
- [2]. Yang D, et al. Hydroxycitric acid inhibits ferroptosis and ameliorates benign prostatic hyperplasia by upregulating the Nrf2/GPX4 pathway. World J Urol. 2025;43(1):318. Published 2025 May 20. [Content Brief]
- [3]. Wang S, et al. Hydroxycitric Acid Tripotassium Hydrate Attenuates Monocrotaline and Hypoxia-Induced Pulmonary Hypertension in Rats. Int Heart J. 2024;65(2):318-328. [Content Brief]
- [4]. Yang B, et al. Hydroxycitric acid prevents hyperoxaluric-induced nephrolithiasis and oxidative stress via activation of the Nrf2/Keap1 signaling pathway. Cell Cycle. 2023;22(17):1884-1899. [Content Brief]
