Citric acid triammonium
Based on 10 publication(s) in Google Scholar
Citric acid triammonium (Triammonium citrate) is a natural preservative and food tartness enhancer. Citric acid triammonium induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid triammonium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid triammonium is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 3458-72-8
- Formula: C6H17N3O7
- Molecular Weight:243.22
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-Y1325I
Sodium acetate trihydrate, 99.5% -
HY-W251598C
Sodium bicarbonate, for cell culture -
HY-Y1891
Tween 80 -
HY-Y1369C
Manganese sulfate monohydrate, for cell culture -
HY-D0856
Bis-Tris -
HY-D0877
TAPS -
HY-B1610
Sodium citrate dihydrate -
HY-D0871
CHES -
HY-W251598B
Sodium bicarbonate, for molecular biology -
HY-D0866
ACES
Publications Citing Use of MedChemExpress (MCE) Citric acid triammonium
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Mol Cancer. 2025 Oct 2;24(1):238. [Abstract]
- Cell Rep Med. 2026 Feb 17;7(2):102621. [Abstract]
- Food Chem. 2025 Oct 15:489:144992. [Abstract]
- Food Chem. 2023 Mar 30;405(Pt A):134807. [Abstract]
- Food Res Int. 2026 Feb 6.
- Life Sci. 2024 Jun 15:347:122682. [Abstract]
- BMC Complement Med Ther. 2026 Apr 2;26(1):177. [Abstract]
- J Sep Sci. 2025 Nov;48(11):e70312. [Abstract]
- New J Chem. 03 Aug 2022.
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
In Vitro
Citric acid triammonium (Triammonium citrate) can serve as an electrolyte additive; it refines PbSO4 grains in the pure lead foil negative electrode of lead-acid batteries, modifies the PbSO4 morphology into a layered stacked structure, inhibits sulfation, reduces charge-transfer resistance, and suppresses the hydrogen evolution reaction[5].
Triammonium citrate enhances the high-rate partial state-of-charge (HRPSoC) cycling performance and high-rate discharge specific capacity of pure lead foil lead-acid batteries[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3458-72-8
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Appearance Solid
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Molecular Weight 243.22
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Formula C6H17N3O7
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Color White to off-white
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SMILES
O=C(CC(C(O)=O)(O)CC(O)=O)O.[3NH3]
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Synonyms
Triammonium citrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (10)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Mol Cancer
Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization. [Abstract]2025 Oct 2;24(1):238. PMID: 41039575 -
Cell Rep Med
Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer. [Abstract]2026 Feb 17;7(2):102621. PMID: 41707647 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
Food Chem
Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]2023 Mar 30;405(Pt A):134807. PMID: 36370576 -
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Life Sci
Homogentisic acid metabolism inhibits papillary thyroid carcinoma proliferation through ROS and p21-induced cell cycle arrest. [Abstract]2024 Jun 15:347:122682. PMID: 38702025 -
BMC Complement Med Ther
Hepatotoxicity prediction for traditional Chinese medicine: a two-step in silico framework integrating network and machine learning approaches. [Abstract]2026 Apr 2;26(1):177. PMID: 41923057 -
J Sep Sci
Cell Metabolomics Reveals the Hepatotoxic Mechanism of Copper in Normal Rat Liver Cells Using Reversed-Phase and Hydrophilic Interaction Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry. [Abstract]2025 Nov;48(11):e70312. PMID: 41172059 -
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (411.15 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (287 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. [Content Brief]
[2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. [Content Brief]
[3]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. [Content Brief]
[4]. Ciriminna R, et al. Citric acid: emerging applications of key biotechnology industrial product. Chem Cent J. 2017 Mar 8;11:22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.1115 mL | 20.5575 mL | 41.1150 mL | 102.7876 mL |
| 5 mM | 0.8223 mL | 4.1115 mL | 8.2230 mL | 20.5575 mL | |
| 10 mM | 0.4112 mL | 2.0558 mL | 4.1115 mL | 10.2788 mL | |
| 15 mM | 0.2741 mL | 1.3705 mL | 2.7410 mL | 6.8525 mL | |
| 20 mM | 0.2056 mL | 1.0279 mL | 2.0558 mL | 5.1394 mL | |
| 25 mM | 0.1645 mL | 0.8223 mL | 1.6446 mL | 4.1115 mL | |
| 30 mM | 0.1371 mL | 0.6853 mL | 1.3705 mL | 3.4263 mL | |
| 40 mM | 0.1028 mL | 0.5139 mL | 1.0279 mL | 2.5697 mL | |
| 50 mM | 0.0822 mL | 0.4112 mL | 0.8223 mL | 2.0558 mL | |
| 60 mM | 0.0685 mL | 0.3426 mL | 0.6853 mL | 1.7131 mL | |
| 80 mM | 0.0514 mL | 0.2570 mL | 0.5139 mL | 1.2848 mL | |
| 100 mM | 0.0411 mL | 0.2056 mL | 0.4112 mL | 1.0279 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Citric acid triammonium Related Classifications
HY-B1529A Related Classifications
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