Ammonium citrate dibasic, 99%
Based on 10 publication(s) in Google Scholar
Ammonium citrate dibasic, 99% (Ammonium hydrogencitrate, 99%; Diammonium hydrogen citrate, 99%) is a natural preservative and food tartness enhancer. Ammonium citrate dibasic, 99% induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Ammonium citrate dibasic, 99% cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Ammonium citrate dibasic, 99% is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 3012-65-5
- Formula: C6H14N2O7
- Molecular Weight:226.18
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-D0227F
THAM hydrochloride (≥99%, reagent grade) -
HY-D0850
Tartaric acid disodium dihydrate -
HY-D0858B
MES sodium salt -
HY-D0227A
THAM hydrochloride -
HY-D0227J
THAM hydrochloride (≥99%, for cell culture) -
HY-D0858
MES -
HY-B1610
Sodium citrate dihydrate -
HY-B0167
Salicylic acid -
HY-B1610I
Sodium citrate dihydrate, for molecular biology -
HY-D0859
MOPS -
HY-D0875
PIPES -
HY-B1610E
Sodium citrate dihydrate, meets USP testing specifications
Publications Citing Use of MedChemExpress (MCE) Ammonium citrate dibasic, 99%
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Mol Cancer. 2025 Oct 2;24(1):238. [Abstract]
- Cell Rep Med. 2026 Feb 17;7(2):102621. [Abstract]
- Food Chem. 2025 Oct 15:489:144992. [Abstract]
- Food Chem. 2023 Mar 30;405(Pt A):134807. [Abstract]
- Food Res Int. 2026 Feb 6.
- Life Sci. 2024 Jun 15:347:122682. [Abstract]
- BMC Complement Med Ther. 2026 Apr 2;26(1):177. [Abstract]
- J Sep Sci. 2025 Nov;48(11):e70312. [Abstract]
- New J Chem. 03 Aug 2022.
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
In Vitro
Ammonium citrate dibasic, 99% (Triammonium citrate) can serve as an electrolyte additive; it refines PbSO4 grains in the pure lead foil negative electrode of lead-acid batteries, modifies the PbSO4 morphology into a layered stacked structure, inhibits sulfation, reduces charge-transfer resistance, and suppresses the hydrogen evolution reaction[5].
Triammonium citrate enhances the high-rate partial state-of-charge (HRPSoC) cycling performance and high-rate discharge specific capacity of pure lead foil lead-acid batteries[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3012-65-5
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Appearance Solid
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Molecular Weight 226.18
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Formula C6H14N2O7
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Color White to off-white
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SMILES
O=C(CC(C(O)=O)(O)CC(O)=O)O.N.N
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Synonyms
Ammonium hydrogencitrate, 99%; Diammonium hydrogen citrate, 99%
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (10)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Mol Cancer
Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization. [Abstract]2025 Oct 2;24(1):238. PMID: 41039575 -
Cell Rep Med
Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer. [Abstract]2026 Feb 17;7(2):102621. PMID: 41707647 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
Food Chem
Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]2023 Mar 30;405(Pt A):134807. PMID: 36370576 -
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Life Sci
Homogentisic acid metabolism inhibits papillary thyroid carcinoma proliferation through ROS and p21-induced cell cycle arrest. [Abstract]2024 Jun 15:347:122682. PMID: 38702025 -
BMC Complement Med Ther
Hepatotoxicity prediction for traditional Chinese medicine: a two-step in silico framework integrating network and machine learning approaches. [Abstract]2026 Apr 2;26(1):177. PMID: 41923057 -
J Sep Sci
Cell Metabolomics Reveals the Hepatotoxic Mechanism of Copper in Normal Rat Liver Cells Using Reversed-Phase and Hydrophilic Interaction Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry. [Abstract]2025 Nov;48(11):e70312. PMID: 41172059 -
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (442.13 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (596 KB)
- English - EN (596 KB)
- Français - FR (596 KB)
- Deutsch - DE (596 KB)
- Norwegian - NO (596 KB)
- Español - ES (596 KB)
- Swedish - SV (596 KB)
- Italian - IT (596 KB)
- Korean - KR (596 KB)
- Portuguese - PT (596 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. [Content Brief]
[2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. [Content Brief]
[3]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. [Content Brief]
[4]. Ciriminna R, et al. Citric acid: emerging applications of key biotechnology industrial product. Chem Cent J. 2017 Mar 8;11:22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.4213 mL | 22.1063 mL | 44.2126 mL | 110.5314 mL |
| 5 mM | 0.8843 mL | 4.4213 mL | 8.8425 mL | 22.1063 mL | |
| 10 mM | 0.4421 mL | 2.2106 mL | 4.4213 mL | 11.0531 mL | |
| 15 mM | 0.2948 mL | 1.4738 mL | 2.9475 mL | 7.3688 mL | |
| 20 mM | 0.2211 mL | 1.1053 mL | 2.2106 mL | 5.5266 mL | |
| 25 mM | 0.1769 mL | 0.8843 mL | 1.7685 mL | 4.4213 mL | |
| 30 mM | 0.1474 mL | 0.7369 mL | 1.4738 mL | 3.6844 mL | |
| 40 mM | 0.1105 mL | 0.5527 mL | 1.1053 mL | 2.7633 mL | |
| 50 mM | 0.0884 mL | 0.4421 mL | 0.8843 mL | 2.2106 mL | |
| 60 mM | 0.0737 mL | 0.3684 mL | 0.7369 mL | 1.8422 mL | |
| 80 mM | 0.0553 mL | 0.2763 mL | 0.5527 mL | 1.3816 mL | |
| 100 mM | 0.0442 mL | 0.2211 mL | 0.4421 mL | 1.1053 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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