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Results for "

DOCK2

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Natural
Products

1

Isotope-Labeled Compounds

4

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-110100
    CPYPP
    3 Publications Verification

    		 DOCK Inflammation/Immunology
    CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2 DHR-2 for Rac1 in a dose-dependent manner with an IC50 of 22.8 µM. CPYPP also inhibits DOCK180 and DOCK5 and less inhibits DOCK9 .
    CPYPP
  • HY-111355B
    Cholesteryl sulfate sodium

    		Sirtuin Endogenous Metabolite PKC AMPK DOCK Metabolic Disease Inflammation/Immunology Cancer
    Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC50 values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions [2] .
    Cholesteryl sulfate sodium
  • HY-153128
    DOCK2-IN-1

    		DOCK Drug Derivative Inflammation/Immunology
    DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases .
    DOCK2-IN-1
  • HY-111355
    Cholesterol sulfate

    		Endogenous Metabolite DOCK PKC AMPK Sirtuin Metabolic Disease Inflammation/Immunology Cancer
    Cholesterol sulfate is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate acts as a DOCK2 inhibitor, with IC50 values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions [2] .
    Cholesterol sulfate
  • HY-RS03924
    DOCK2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DOCK2 Human Pre-designed siRNA Set A contains three designed siRNAs for DOCK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DOCK2 Human Pre-designed siRNA Set A
    DOCK2 Human Pre-designed siRNA Set A
  • HY-RS18172
    Dock2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dock2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dock2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dock2 Mouse Pre-designed siRNA Set A
    Dock2 Mouse Pre-designed siRNA Set A
  • HY-RS24646
    Dock2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dock2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dock2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dock2 Rat Pre-designed siRNA Set A
    Dock2 Rat Pre-designed siRNA Set A
  • HY-111355S
    Cholesterol sulfate-d7 sodium

    		Isotope-Labeled Compounds Sirtuin Endogenous Metabolite PKC AMPK DOCK Metabolic Disease Inflammation/Immunology Cancer
    Cholesterol sulfate sodium-d7 is the deuterium labeled Cholesterol sulfate sodium. Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC50 values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions.
    Cholesterol sulfate-d7 sodium

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