DOCK2 Antibody (YA2710)(PBS only)

Cat. No.: HY-P82965A: Fiche technique User Guide for Antibodies
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Technical Support

DOCK2 Antibody (YA2710) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DOCK2.

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Size		Stock
50 μL		Obtenir un devis
100 μL		Obtenir un devis

* Veuillez sélectionner la quantité avant d'ajouter des articles.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Description

Description

DOCK2 Antibody (YA2710) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DOCK2.

Host

Rabbit

Masse moléculaire

Predicted band size: 212 kDa;

Observed band size: 212 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q92608

Gene ID

1794 [NCBI]

Immunogen

A synthetic peptide of human DOCK2

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:5000

Pureté	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Livraison

Shipping with blue ice.

Background

Function：Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2

Subcellular Localization：Endomembrane system; Peripheral membrane protein; Cytoplasm, cytoskeleton

Expression：
Tissue_specificity:Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon

Isoforms & Post-Translational Modification：Q92608 has 2 isomers: Q92608-1: 211948 Da (predicted); Q92608-2: 38461 Da (predicted).

Subunit：Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z

Research Field

Signal Transduction

Synonyms

DOCK 2; IMD40

Documentation

User Guide for Antibodies (1077 KB)