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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
E3 Enzyme
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "E3 Enzyme" in MCE Product Catalog:
26
26 Publications Verification
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Research Areas:
PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 μM, with little activity at E2 and E3.
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4 Cited Publications
Cat. No.: HY-P79449
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2D2; Ubiquitin Conjugating Enzyme E2 D2; UBC4; UbcH5B; Ubiquitin‑Conjugating Enzyme E2D 2 (Homologous To Yeast UBC4/5); (E3‑Independent) E2 Ubiquitin‑Conjugating Enzyme D2; P53‑Regulated Ubiquitin‑Conjugating Enzyme 1; Ubiquitin‑Conjugating Enzyme E2‑1
3
3 Cited Publications
Cat. No.: HY-P70998
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2D3; Ubiquitin Conjugating Enzyme E2 D3; UbcH5C; Ubiquitin‑Conjugating Enzyme E2D 3 (Homologous To Yeast UBC4/5); Ubiquitin‑Conjugating Enzyme E2D 3 (UBC4/5 Homolog,Yeast); (E3‑Independent) E2 Ubiquitin‑Conjugating Enzyme D3; Ubiquitin‑Conjugating Enzy
Synonyms: Cbl-b-IN-3
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NX-1607 (Compound 23) is an inhibitor of Cbl-b, an E3 enzyme in the ubiquitin-proteasome pathway, with an IC50 value of less than 1 nM. NX-1607 can be used in cancer research .
Cat. No.: HY-148381
CAS No.: 2378056-80-3
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A947 is a VHL-based SMARCA2 PROTAC degrader with a DC50 of 39 pM and a Kd of 93 nM for human SMARCA2. A947 recruits SMARCA2 to the VHL E3 ubiquitin ligase for ubiquitination modification, mediates its degradation via the proteasome, and exerts selective degradation effects on SMARCA4 and PBRM1. A947 induces G1 cell cycle arrest, inhibits transcription, and exerts growth inhibitory effects in SMARCA4 G12C-mutant cancer cells. A947 acts synergistically with MCL1 inhibitors to induce apoptosis in SMARCA4 G12C-mutant cancer cells. A947 can be used in studies related to SMARCA4 G12C-mutant non-small cell lung cancer and non-small cell lung cancer .
Cat. No.: HY-174444A
PROTAC HDAC degrader-2 TFA is the trifluoroacetate salt of PROTAC HDAC degrader-2. PROTAC HDAC degrader-2 is a selective IIb HDACs PROTAC degrader, with DC50s of 13 nM for HDAC6, 29 nM for HDAC10, respectively. PROTAC HDAC degrader-2 exhibits low cytotoxicity against hematological and solid cancer cell lines. PROTAC HDAC degrader-2 can be used for the chemical knockdown of class IIb HDACs .
Cat. No.: HY-141431
CAS No.: 2503325-21-9
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Cbl-b-IN-2 (Example 8) is an orally bioavailable compound, can inhibit the E3 enzyme Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) in the ubiquitin proteasome pathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases amenable to immune system modulation. Cbl-b-IN-2 (Example 8) also may be administered to an individual with cancer, either alone or as part of a combination, with one or more of an immune checkpoint inhibitor, an anti-neoplastic agent, and radiation agent .
Cat. No.: HY-174444
PROTAC HDAC degrader-2 is a selective IIb HDACs PROTAC degrader, with DC50s of 13 nM for HDAC6, 29 nM for HDAC10, respectively. PROTAC HDAC degrader-2 exhibits low cytotoxicity against hematological and solid cancer cell lines. PROTAC HDAC degrader-2 can be used for the chemical knockdown of class IIb HDACs .
Cat. No.: HY-141432G
CAS No.: 2573775-59-2
Synonyms: Cbl-b-IN-3 (GMP)
Cat. No.: HY-168869
CAS No.: 3104316-29-9
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Tamoxifen-PEG-Clozapine is a ERα PROTAC degrader. Tamoxifen-PEG-Clozapine induces ubiquitination and degradation of ERα protein. Tamoxifen-PEG-Clozapine mediates ERα degradation by utilizing UBR5 as a component of the ubiquitin-proteasome system. Tamoxifen-PEG-Clozapine exhibits anticancer activity against breast cancer. Tamoxifen-PEG-Clozapine can be used in the research of breast cancer .
Cat. No.: HY-E71082
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(E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) transfers a single ubiquitin directly from an ubiquitinated E1 ubiquitin-activating enzyme to itself, and on to a lysine residue of the acceptor protein without involvement of E3 ubiquitin transferases.
Cat. No.: HY-161960
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EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958) .
Cat. No.: HY-L050
494 compounds
Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.
MCE offers a unique collection of 494 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.
Cat. No.: HY-P701487
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2E3; Ubiquitin Conjugating Enzyme E2 E3; UbcH9; Ubiquitin‑Conjugating Enzyme E2E 3 (Homologous To Yeast UBC4/5); Ubiquitin‑Conjugating Enzyme E2E 3 (UBC4/5 Homolog,Yeast); Ubiquitin‑Conjugating Enzyme E2‑23 KDa; Ubiquitin‑Conjugating Enzyme E2 E3; E2 U
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Cat. No.: HY-P701490
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2E3; Ubiquitin Conjugating Enzyme E2 E3; UbcH9; Ubiquitin‑Conjugating Enzyme E2E 3 (Homologous To Yeast UBC4/5); Ubiquitin‑Conjugating Enzyme E2E 3 (UBC4/5 Homolog,Yeast); Ubiquitin‑Conjugating Enzyme E2‑23 KDa; Ubiquitin‑Conjugating Enzyme E2 E3; E2 U
Species:
Source:
Cat. No.: HY-L045
4,246 compounds
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.
HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O2 concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.
MCE offers a unique collection of 4,246 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.
Cat. No.: HY-185391
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DCAF1 ligand 2 (Tert-butyl (2-((2-(1-(4-chlorophenyl)cyclohexyl)-7-(piperazin-1-yl)quinazolin-4-yl)amino)ethyl)carbamate) is a ligand of the E3 connecting enzyme DCAF1. DCAF1 ligand 2 can be used for the synthesis of PROTACs .
Cat. No.: HY-P71403
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2I; Ubiquitin Conjugating Enzyme E2 I; UBC9; RING‑Type E3 SUMO Transferase UBC9; SUMO‑Conjugating Enzyme UBC9; Ubiquitin Carrier Protein 9; Ubiquitin Carrier Protein I; Ubiquitin‑Protein Ligase I; SUMO‑Protein Ligase; Ubiquitin‑Conjugating Enzyme E2I (
Cat. No.: HY-P76688A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2F; Ubiquitin Conjugating Enzyme E2 F (Putative); NCE2; Ubiquitin‑Conjugating Enzyme E2F (Putative); RING‑Type E3 NEDD8 Transferase UBE2F; NEDD8‑Conjugating Enzyme UBE2F; NEDD8 Carrier Protein UBE2F; NEDD8 Protein Ligase UBE2F; NEDD8‑Conjugating Enzyme
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
