3104316-29-9
Chemical Structure
Tamoxifen-PEG-Clozapine
- CAS No.: 3104316-29-9
- Formula:C54H63ClN6O7
- Molecular Weight:943.57
InChIKey: CSMUZRSXZXLELT-YVUJEYQCSA-N
SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C(CCC(NCCOCCOCCOCCN3CCN(CC3)C4=NC5=CC(Cl)=CC=C5NC6=CC=CC=C64)=O)=O)C)/C7=CC=C(C=C7)O
Biological Activity: Tamoxifen-PEG-Clozapine is a ERα PROTAC degrader. Tamoxifen-PEG-Clozapine induces ubiquitination and degradation of ERα protein. Tamoxifen-PEG-Clozapine mediates ERα degradation by utilizing UBR5 as a component of the ubiquitin-proteasome system. Tamoxifen-PEG-Clozapine exhibits anticancer activity against breast cancer. Tamoxifen-PEG-Clozapine can be used in the research of breast cancer[1].
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Tamoxifen-PEG-Clozapine | Tamoxifen-PEG-Clozapine is a ERα PROTAC degrader. Tamoxifen-PEG-Clozapine induces ubiquitination and degradation of ERα protein. Tamoxifen-PEG-Clozapine mediates ERα degradation by utilizing UBR5 as a component of the ubiquitin-proteasome system. Tamoxifen-PEG-Clozapine exhibits anticancer activity against breast cancer. Tamoxifen-PEG-Clozapine can be used in the research of breast cancer. | |||||||||||||||||||||
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