1 Result for "

EGFR-IN-154

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "EGFR-IN-154" in MCE Product Catalog:

Cat. No.: HY-173188
Target:  

EGFR Akt PERK JNK p38 MAPK

Research Areas:  

Cancer

EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 μM, 21.73 μM and 41.56 μM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels .
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