EGFR-IN-154
EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 μM, 21.73 μM and 41.56 μM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C20H21N5O2
- Peso molecular:363.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Actividad biológica
Descripciòn
Chemical Information
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Peso molecular 363.41
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Fòrmula C20H21N5O2
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SMILES
N=C(NC1CC1)C(C=C2)=CC=C2NC3=NC=NC4=C3C=C(OC)C(OC)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-154 Related Classifications
HY-173188 Related Classifications
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