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EGFR-IN-154

EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 μM, 21.73 μM and 41.56 μM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels.

For research use only. We do not sell to patients.

  • Formula: C20H21N5O2
  • Molecular Weight:363.41
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • EGFR-IN-154 Chemical Structure
    EGFR-IN-154 Chemical Structure
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All EGFR Isoforms

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All Akt Isoforms

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All JNK Isoforms

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All p38 MAPK Isoforms

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100 mg

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  • EGFR-IN-154 Chemical Structure
    EGFR-IN-154 Chemical Structure
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  • EGFR-IN-154