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1 Result for "
Estradiol 3-methyl ether
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "Estradiol 3-methyl ether" in MCE Product Catalog:
Cat. No.: HY-W008581
CAS No.: 1035-77-4
Synonyms: 3-O-methyl Estradiol; 17β-Estradiol 3-methyl ether; 3-MethoxyEstradiol
Research Areas:
Estradiol 3-methyl ether (EDME) is a highly selective TRPML1 ion channel antagonist and microtubule (microtubule) depolymerizing agent, with IC50 values of 0.22 μM and 3.8 μM against TRPML1 and TRPML2, respectively; it shows no activity against TRPML3. Estradiol 3-methyl ether induces the disruption of cytoplasmic microtubule networks in mammalian cells, with an EC50 of 9 μM. Independent of estrogen receptors, Estradiol 3-methyl ether blocks autophagy (autophagy), TFEB nuclear translocation, and inhibits the migration and invasion of triple-negative breast cancer cells by suppressing TRPML1. Estradiol 3-methyl ether is applicable for relevant research on triple-negative breast cancer .
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Protocols
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