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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
GX
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "GX" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: GX15-070 Mesylate
Target:
Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2 . Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity .
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Target:
Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2 . Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity .
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4 Cited Publications
Cat. No.: HY-D0001
CAS No.: 33864-99-2
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GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7 .
Cat. No.: HY-W357818
CAS No.: 18865-38-8
Synonyms: GX
Cat. No.: HY-P99932
CAS No.: 1905448-17-0
Synonyms: TJ-101; GX-H9; hGH-hyFc; HL-2356
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Cat. No.: HY-120078
CAS No.: 1845753-81-2
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AZD2716 is an orally active secretory phospholipase A2 (sPLA2) inhibitor. AZD2716 inhibits human GIIA sPLA2 (IC50=10 nM), human GV sPLA2 (IC50=40 nM), human GX sPLA2 (IC50=400 nM), snake venom sPLA2 (IC50=2 pM), and snake (Bothrops jararacussu) Lys49-PLA2-like toxin (Kd=110 μM). AZD2716 inhibits sPLA2 isoforms IIa, V, X, snake venom sPLA2s, and snake venom Lys49-PLA2-like toxin myotoxic activity via hydrophobic channel binding. AZD2716 suppresses GIIA sPLA2 production, neutralizes snake venom-induced myotoxicity, and improves survival in envenomed mice. AZD2716 can be used for the research of coronary artery disease, atherosclerosis, and snakebite envenoming .
Cat. No.: HY-123825
CAS No.: 1432913-36-4
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GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 of 0.1 nM at -40 mV .
Cat. No.: HY-123414
CAS No.: 1235406-09-3
Synonyms: PF-05196233
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GX-936 (PF-05196233), a potent and Nav1.7-subtype selective inhibitor, binds to the activated state of voltage-sensor domain IV (VSD4) .
Cat. No.: HY-167852
CAS No.: 2098540-08-8
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GX-585 is a sulfonamide analog that acts as a Nav1.7 channel inhibitor, demonstrating analgesic activity in treating neuropathic pain and inflammation.
Cat. No.: HY-101621
CAS No.: 108700-03-4
Synonyms: GR53992B; GX1296B
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Teludipine is a lipophilic calcium channel blocker.
Cat. No.: HY-RS13441
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SMO Human Pre-designed siRNA Set A contains three designed siRNAs for SMO gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-143971S
CAS No.: 1217098-46-8
Synonyms: GX-d6
Cat. No.: HY-RS11592
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RAC2 Human Pre-designed siRNA Set A contains three designed siRNAs for RAC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P11415
CAS No.: 1189359-89-4
Cat. No.: HY-10969R
CAS No.: 803712-79-0
Synonyms: GX15-070 Mesylate (Standard)
Obatoclax mesylate (Standard) is the analytical standard of Obatoclax (Mesylate) (HY-10969). This product is intended for research and analytical applications. Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2 . Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity .
Cat. No.: HY-P72208
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GNAZ; Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide; G Protein Subunit Alpha Z; Heterotrimeric Guanine Nucleotide-Binding Protein 1H; Guanine Nucleotide-Binding Protein G(Z) Subunit Alpha; Transducin Alpha; G(X) Alpha Chain; HG1H; Gz
Cat. No.: HY-P74607
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: RAC2; Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP-Binding Protein Rac2); Rac Family Small GTPase 2; Small Monomeric GTPase; EN-7; HSPC022; Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2); IMD73
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
