GX-674

Cat. No.: HY-123825 Purity: 98.45%: Data Sheet
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GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC₅₀ of 0.1 nM at -40 mV.

For research use only. We do not sell to patients.

GX-674 Chemical Structure

CAS No. : 1432913-36-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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View All Isoforms

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8 Na_v1.9

Biological Activity
Purity & Documentation
References
Customer Review

Description

GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC₅₀ of 0.1 nM at -40 mV^[1].

IC₅₀ & Target

hNa_v1.7

0.1 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.2 nM Compound: 16	Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by automated voltage clamp analysis Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	0.3 nM Compound: 16	Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by automated voltage clamp analysis Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	0.3 nM Compound: 16	Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage clamp analysis Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	0.8 nM Compound: 16	Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by automated voltage clamp analysis Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	30 nM Compound: 30	Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assay Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assay	[PMID: 25927480]
HEK293	IC₅₀	3850 nM Compound: 16	Inhibition of full length human Nav1.8 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at holding potential -20 mV by manual voltage clamp analysis Inhibition of full length human Nav1.8 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at holding potential -20 mV by manual voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	6380 nM Compound: 16	Inhibition of full length human Nav1.1 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -40 mV by automated voltage clamp analysis Inhibition of full length human Nav1.1 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -40 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	9330 nM Compound: 16	Inhibition of full length human Nav1.3 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -50 mV by automated voltage clamp analysis Inhibition of full length human Nav1.3 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -50 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	> 10 μM Compound: 30	Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assay Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assay	[PMID: 25927480]
HEK293	IC₅₀	> 10000 nM Compound: 16	Inhibition of full length human Nav1.4 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 by automated voltage clamp analysis Inhibition of full length human Nav1.4 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	> 10000 nM Compound: 16	Inhibition of full length human Nav1.5 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by automated voltage clamp analysis Inhibition of full length human Nav1.5 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by automated voltage clamp analysis	[PMID: 26985315]

Molecular Weight

534.95

Formula

C₂₁H₁₃ClF₂N₆O₃S₂

CAS No.

1432913-36-4

Appearance

Solid

Color

Off-white to light brown

SMILES

O=S(C1=CC(F)=C(OC2=CC=C(Cl)C=C2C3=CC=C4N=C(N)NC4=C3)C=C1F)(NC5=NC=NS5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (93.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8693 mL	9.3467 mL	18.6933 mL
5 mM	0.3739 mL	1.8693 mL	3.7387 mL
10 mM	0.1869 mL	0.9347 mL	1.8693 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.45%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (255 KB) HNMR (316 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Ahuja S, et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science. 2015 Dec 18;350(6267):aac5464. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8693 mL	9.3467 mL	18.6933 mL	46.7333 mL
	5 mM	0.3739 mL	1.8693 mL	3.7387 mL	9.3467 mL
	10 mM	0.1869 mL	0.9347 mL	1.8693 mL	4.6733 mL
	15 mM	0.1246 mL	0.6231 mL	1.2462 mL	3.1156 mL
	20 mM	0.0935 mL	0.4673 mL	0.9347 mL	2.3367 mL
	25 mM	0.0748 mL	0.3739 mL	0.7477 mL	1.8693 mL
	30 mM	0.0623 mL	0.3116 mL	0.6231 mL	1.5578 mL
	40 mM	0.0467 mL	0.2337 mL	0.4673 mL	1.1683 mL
	50 mM	0.0374 mL	0.1869 mL	0.3739 mL	0.9347 mL
	60 mM	0.0312 mL	0.1558 mL	0.3116 mL	0.7789 mL
	80 mM	0.0234 mL	0.1168 mL	0.2337 mL	0.5842 mL

GX-674 Related Classifications

Neurological Disease Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GX-6741432913-36-4GX674GX 674Sodium ChannelNa channelsNa+ channelspainneurological disorderscardiovascular disordersstate-dependentInhibitorinhibitorinhibit

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GX-674

Customer Review

GX-674 Related Antibodies

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View All Sodium Channel Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

GX-674 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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