Cat. No.: HY-123825

GX-674

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Based on 1 Customer Validation

GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC₅₀ of 0.1 nM at -40 mV.

For research use only. We do not sell to patients.

Purity: 98.45%
CAS No.: 1432913-36-4
Formula: C₂₁H₁₃ClF₂N₆O₃S₂
Molecular Weight:534.95

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

GX-674 Chemical Structure

CAS No.: 1432913-36-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC₅₀ of 0.1 nM at -40 mV^[1].

IC₅₀ & Target

hNa_v1.7

0.1 nM (IC₅₀)

All Sodium Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>10 μM Compound: 30	Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assay Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assay	[PMID: 25927480]
HEK293	IC₅₀	30 nM Compound: 30	Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assay Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assay	[PMID: 25927480]
HEK293	IC₅₀	>10000 nM Compound: 16	Inhibition of full length human Nav1.5 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by automated voltage clamp analysis Inhibition of full length human Nav1.5 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	0.2 nM Compound: 16	Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by automated voltage clamp analysis Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	0.3 nM Compound: 16	Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by automated voltage clamp analysis Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	0.3 nM Compound: 16	Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage clamp analysis Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	0.8 nM Compound: 16	Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by automated voltage clamp analysis Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	3850 nM Compound: 16	Inhibition of full length human Nav1.8 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at holding potential -20 mV by manual voltage clamp analysis Inhibition of full length human Nav1.8 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at holding potential -20 mV by manual voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	6380 nM Compound: 16	Inhibition of full length human Nav1.1 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -40 mV by automated voltage clamp analysis Inhibition of full length human Nav1.1 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -40 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	9330 nM Compound: 16	Inhibition of full length human Nav1.3 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -50 mV by automated voltage clamp analysis Inhibition of full length human Nav1.3 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -50 mV by automated voltage clamp analysis	[PMID: 26985315]
HEK293	IC₅₀	>10000 nM Compound: 16	Inhibition of full length human Nav1.4 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 by automated voltage clamp analysis Inhibition of full length human Nav1.4 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 by automated voltage clamp analysis	[PMID: 26985315]

Chemical Information

CAS No. 1432913-36-4
Appearance Solid
Molecular Weight 534.95
Formula C₂₁H₁₃ClF₂N₆O₃S₂
Color Off-white to light brown
SMILES

O=S(C1=CC(F)=C(OC2=CC=C(Cl)C=C2C3=CC=C4N=C(N)NC4=C3)C=C1F)(NC5=NC=NS5)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (93.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8693 mL

9.3467 mL

18.6933 mL

5 mM

0.3739 mL

1.8693 mL

3.7387 mL

10 mM

0.1869 mL

0.9347 mL

1.8693 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahuja S, et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science. 2015 Dec 18;350(6267):aac5464. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8693 mL	9.3467 mL	18.6933 mL	46.7333 mL
	5 mM	0.3739 mL	1.8693 mL	3.7387 mL	9.3467 mL
	10 mM	0.1869 mL	0.9347 mL	1.8693 mL	4.6733 mL
	15 mM	0.1246 mL	0.6231 mL	1.2462 mL	3.1156 mL
	20 mM	0.0935 mL	0.4673 mL	0.9347 mL	2.3367 mL
	25 mM	0.0748 mL	0.3739 mL	0.7477 mL	1.8693 mL
	30 mM	0.0623 mL	0.3116 mL	0.6231 mL	1.5578 mL
	40 mM	0.0467 mL	0.2337 mL	0.4673 mL	1.1683 mL
	50 mM	0.0374 mL	0.1869 mL	0.3739 mL	0.9347 mL
	60 mM	0.0312 mL	0.1558 mL	0.3116 mL	0.7789 mL
	80 mM	0.0234 mL	0.1168 mL	0.2337 mL	0.5842 mL

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GX-674

Membrane Transporter/Ion Channel Compound Library

Anti-Cardiovascular Disease Compound Library

Neuroprotective Compound Library

Mechanoreceptors Compound Library

Sodium Channel Blocker Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

All Sodium Channel Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

GX-674

Membrane Transporter/Ion Channel Compound Library

Anti-Cardiovascular Disease Compound Library

Neuroprotective Compound Library

Mechanoreceptors Compound Library

Sodium Channel Blocker Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

All Sodium Channel Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

GX-674 Related Classifications

Cat. No.: HY-123825