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Results for "

Gram-negative bacterium

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (6) Bacterial (14) Endogenous Metabolite (1) Environmental Pollutants (1) Fungal (1) MOFs (1) Phospholipase (2) Reference Standards (1)
By Research Areas:	Cancer (1) Infection (13) Inflammation/Immunology (3)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128780B

SPR206 acetate 1 Publications Verification	Bacterial Antibiotic	Infection
SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against *Pseudomonas aeruginosa* Pa14 and *Acinetobacter baumannii* NCTC13301 are both 0.125 mg/L .

HY-101128

Bicyclomycin benzoate 2 Publications Verification FR2054	Bacterial Antibiotic	Infection
Bicyclomycin benzoate is an antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium.

HY-W074648

Antibacterial agent 18	MOFs Bacterial	Infection
Antibacterial agent 18 is a multi-arm AIE molecule extracted from patent CN110123801A, compound 23. Antibacterial agent 18 can be used for resisting Gram-positive and Gram-negative bacteria. Antibacterial agent 18 can be conjugated in the cell wall of rigid arm configuration insertion bacterium, and block cell wall turns sugar and turns peptide process, to inhibit or kill bacterium .

HY-W012595A

trans-Benzylideneacetone trans-Benzalacetone	Environmental Pollutants Phospholipase	Inflammation/Immunology
trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant .

HY-162329

Antibacterial agent 195	Bacterial Fungal Antibiotic	Infection Inflammation/Immunology
Antibacterial agent 195 (compound A20), a Matrine (HY-N0164) derivative, is a potent antibiotic. Antibacterial agent 195 shows antibacterial activity against Gram-positive bacterium (MIC_S.aureus=0.021 mg/mL; MIC_P.acnes=0.030 mg/mL), Gram-negative bacterium (MIC_E.coli=0.092 mg/mL; MIC_C.albicans=0.379 mg/mL) and Fungus (MIC=2.806 mg/mL) .

HY-W012595AR

trans-Benzylideneacetone (Standard) trans-Benzalacetone (Standard)	Reference Standards Phospholipase	Inflammation/Immunology
trans-Benzylideneacetone (Standard) is the analytical standard of trans-Benzylideneacetone. This product is intended for research and analytical applications. trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant[1].

HY-N16657

Fusaricidin B LI-F 04b	Bacterial	Infection
Fusaricidin B (LI-F 04b) is one of the components of a lipopeptide biosurfactant extracted from the marine bacterium Paenibacillus polymyxa. Fusaricidin B can significantly inhibit the formation of multiple single species biofilms, including Gram positive and Gram negative bacteria. Fusaricidin B also has inhibitory effects on complex biofilms and can effectively destroy mature biofilms that have already formed. Fusaricidin B can be used for research on bacterial infections .

HY-176776

Antibacterial agent 287	Bacterial Antibiotic	Infection
Antibacterial agent 287 (Compound 26), a derivative of Deoxynybomycin (HY-116926), is an antibacterial agent. Antibacterial agent 287 has potent antibacterial activity against a variety of Gram-negative bacterium with MICs of 0.5, 0.5 and 0.06 μg/mL for WT S. aureus, WT E. coli and E. coli ΔtolC, respectively. Antibacterial agent 287 can be used for multidrug-resistant (MDR) bacterium infections research .

HY-N12096

Galbinic acid α-Acetylsalazinic acid	Bacterial	Infection
Galbinic acid (α-Acetylsalazinic acid), a lichen acid, shows antibacterial activities against the Gram-positive bacteria B. cereus, B. subtilis, and S. aureus (MICs=62.5, 62.5, 250 μg/ml, respectively). Galbinic acid inhibits the Gram-negative bacterium E. coli (MIC=125 μg/ml) .

HY-N16389

Oresbiusin A	Endogenous Metabolite Bacterial	Infection
Oresbiusin A (Compound 6) is a plant secondary metabolite. Oresbiusin A can be isolated from Origanum dictamnus L. Oresbiusin A has antimicrobial activity against Gram-negative bacterium, such as Acinetobacter hemolyticus, Empedobacter brevis and Pseudomonas aeruginosa with a MIC of 0.236 μg/mL for Acinetobacter hemolyticus .

HY-121716

Pelagiomicin A Antibiotic 2088A; LL-14I352α	Bacterial	Cancer
Pelagiomicin A is a novel phenazine antibiotic produced by the marine bacterium Pelagiobacter variabilis. The compound is unstable in water and small alcohols. The absolute structure of its major component, Pelagiomicin A, as well as the properties of minor amounts of other structures, were determined by spectroscopic data and synthesis. Pelagiomicin A is active against both Gram-positive and Gram-negative bacteria and exhibits antitumor activity in vitro and in vivo.

HY-174326

Antibacterial agent 282	Bacterial	Infection
Antibacterial agent 282 (Compound CP7), a seleno-Ciprofloxacin (HY-B0356) derivative, is an Antibacterial agent. Antibacterial agent 282 has significant antibacterial activity against gram-positive bacterium and gram-negative bacterium with MICs of 0.1-1.56 and 0.1-3.13 μg/mL, respectively (MBCs of 0.2-1.56 and 0.39-12.5 μg/mL). Antibacterial agent 282 potently disrupts and prevents biofilms formation of P. aeruginosa. Antibacterial agent 282 shows significant inhibitory activity towards the DNA gyrase from E. coli .

HY-N14354

Ferrocin B	Antibiotic Bacterial	Infection
Ferrocin B is an iron-containing cyclic decapeptide antibiotic found in the bacterium Pseudomonas fluorescens YK-310, exhibiting strong antibacterial activity primarily against Gram-negative bacteria, with particularly potent inhibitory effects on Pseudomonas aeruginosa. In a mouse infection model, Ferrocin B shows a half effective dose (ED₅₀) of 0.593 mg/kg against P. aeruginosa. Ferrocin B holds potential for research in the field of anti-infective therapies .

HY-174852

Antibacterial agent 285	Antibiotic Bacterial	Infection
Antibacterial agent 285 (Compound 3) is a cephalosporin antibiotic. Antibacterial agent 285 has significant antibacterial activity against gram-negative bacterium with MICs of 0.125-0.5, 0.125-0.5 and 0.125-2 μg/mL for carbapenem-resistant Acinetobacter baumannii (CRAB), Klebsiella pneumoniae (CRE) and Pseudomonas aeruginosa (CRPA), respectively. Antibacterial agent 285 can be used for bacterial infection research, such as complicated urinary tract infections (cUTI) and kidney infections .

HY-180330

Antimicrobial agent-46	Bacterial	Infection
Antimicrobial agent-46 is a inhibitor of Salmonella typhimurium serine acetyltransferase (StSAT) with an IC₅₀ of 48.6 μM. Antimicrobial agent-46 inhibits bacterial growth in minimal medium lacking cysteine (LB 20%). Antimicrobial agent-46 exerts its effect by targeting the cysteine biosynthesis pathway, which is crucial for bacterial persistence and adaptability. Antimicrobial agent-46 exhibits antibacterial activity against the Gram-negative bacterium Escherichia coli. Antimicrobial agent-46 can be used in infection-related research .

HY-N17858

Guajaphenone A	Bacterial	Infection
Guajaphenone A is a benzophenone glycoside antibacterial agent that can be found in the leaves of Psidium guajava L. Guajaphenone A inhibits the growth of Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Guajaphenone A is applicable to research related to bacterial infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012595A

trans-Benzylideneacetone trans-Benzalacetone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Phospholipase
trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant .

HY-W012595AR

trans-Benzylideneacetone (Standard) trans-Benzalacetone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Phospholipase
trans-Benzylideneacetone (Standard) is the analytical standard of trans-Benzylideneacetone. This product is intended for research and analytical applications. trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant[1].

HY-N16657

Fusaricidin B LI-F 04b	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Fusaricidin B (LI-F 04b) is one of the components of a lipopeptide biosurfactant extracted from the marine bacterium Paenibacillus polymyxa. Fusaricidin B can significantly inhibit the formation of multiple single species biofilms, including Gram positive and Gram negative bacteria. Fusaricidin B also has inhibitory effects on complex biofilms and can effectively destroy mature biofilms that have already formed. Fusaricidin B can be used for research on bacterial infections .

HY-N12096

Galbinic acid α-Acetylsalazinic acid	Microorganisms Ketones, Aldehydes, Acids Phenols Polyphenols Source Classification	Bacterial
Galbinic acid (α-Acetylsalazinic acid), a lichen acid, shows antibacterial activities against the Gram-positive bacteria B. cereus, B. subtilis, and S. aureus (MICs=62.5, 62.5, 250 μg/ml, respectively). Galbinic acid inhibits the Gram-negative bacterium E. coli (MIC=125 μg/ml) .

HY-N16389

Oresbiusin A	Artemisia judaica L. Animals Labiatae Phenols Polyphenols Plants Lipid Source Classification	Endogenous Metabolite Bacterial
Oresbiusin A (Compound 6) is a plant secondary metabolite. Oresbiusin A can be isolated from Origanum dictamnus L. Oresbiusin A has antimicrobial activity against Gram-negative bacterium, such as Acinetobacter hemolyticus, Empedobacter brevis and Pseudomonas aeruginosa with a MIC of 0.236 μg/mL for Acinetobacter hemolyticus .

HY-121716

Pelagiomicin A Antibiotic 2088A; LL-14I352α	Antibiotics Marine natural products Source Classification	Bacterial
Pelagiomicin A is a novel phenazine antibiotic produced by the marine bacterium Pelagiobacter variabilis. The compound is unstable in water and small alcohols. The absolute structure of its major component, Pelagiomicin A, as well as the properties of minor amounts of other structures, were determined by spectroscopic data and synthesis. Pelagiomicin A is active against both Gram-positive and Gram-negative bacteria and exhibits antitumor activity in vitro and in vivo.

HY-N14354

Ferrocin B	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Ferrocin B is an iron-containing cyclic decapeptide antibiotic found in the bacterium Pseudomonas fluorescens YK-310, exhibiting strong antibacterial activity primarily against Gram-negative bacteria, with particularly potent inhibitory effects on Pseudomonas aeruginosa. In a mouse infection model, Ferrocin B shows a half effective dose (ED₅₀) of 0.593 mg/kg against P. aeruginosa. Ferrocin B holds potential for research in the field of anti-infective therapies .

HY-N17858

Guajaphenone A	Structural Classification Psidium guajava Linn. Phenols Polyphenols Myrtaceae Plants Source Classification	Bacterial
Guajaphenone A is a benzophenone glycoside antibacterial agent that can be found in the leaves of Psidium guajava L. Guajaphenone A inhibits the growth of Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Guajaphenone A is applicable to research related to bacterial infections .

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Gram-negative bacterium

Inhibitors & Agonists

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Natural
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