HI | MedChemExpress (MCE) Life Science Reagents

By Targets:	Apoptosis (2) Cholinesterase (ChE) (3) FLT3 (1) Fluorescent Dye (1) Histamine Receptor (1) HIV (5) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (1) Isotope-Labeled Compounds (2) Lipase (1) Microtubule/Tubulin (1) nAChR (3) Reference Standards (1) Reverse Transcriptase (4) Small Interfering RNA (siRNA) (2) Somatostatin Receptor (1) TOPK (2)
By Research Areas:	Cancer (4) Infection (4) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (3)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101550

HI-TOPK-032 4 Publications Verification	TOPK	Cancer
HI-TOPK-032 is a potent and specific TOPK inhibitor.

HY-153523

Hi 76-0079 1 Publications Verification NNC0076-0079; 76-0079	Lipase	Metabolic Disease
Hi 76-0079 (NNC0076-0079; 76-0079) is a lipase inhibitor that specifically targets hormone-sensitive lipase (HSL). Hi 76-0079 inhibits PNPB Hydrolysis in cell lysates of HEK293A cells overexpressing Lipe with an IC₅₀ value of 0.1 μM. Hi 76-0079 synergizes with the ATGL inhibitor Atglistatin (HY-15859) to block lipolysis in vitro. Hi 76-0079 can be used for the study of lipid metabolism .

HY-D0219

Thymol blue Thymolsulphonephthalein	Fluorescent Dye	Others
Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

HY-106901A

Asoxime dichloride HI-6	Cholinesterase (ChE) nAChR	Neurological Disease
Asoxime dichloride (HI-6) is an orally active thiosemicarbazone-based antidote. Asoxime dichloride is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dichloride significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dichloride is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dichloride can serve as an effective immunomodulator, improving the immune effect of the nervous system .

HY-106901AS

Asoxime-d4 dichloride 1 Publications Verification HI-6-d₄	Isotope-Labeled Compounds Cholinesterase (ChE) nAChR	Neurological Disease
Asoxime-d₄ dichloride (HI-6-d₄) is the deuterium labeled Asoxime dichloride. Asoxime dichloride is an orally active thiosemicarbazone-based antidote. Asoxime dichloride is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dichloride significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dichloride is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dichloride can serve as an effective immunomodulator, improving the immune effect of the nervous system.

HY-118711

HI-346	HIV Reverse Transcriptase	Infection
HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC₅₀ value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC₅₀ value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research .

HY-164040

Zavolosotine	Somatostatin Receptor	Metabolic Disease
Zavolosotine (Compound 1) is an orally active agonist for somatostatin receptor type 5 (SST5) with EC₅₀ <1 nM. Zavolosotine inhibits insulin and glucagon secretion, increases levels of glucagon in blood in rat model .

HY-105386

HI-280	HIV Reverse Transcriptase	Infection
HI-280 is a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor. HI-280 can be used for the research of infection .

HY-121611

HI-236	HIV	Inflammation/Immunology
HI-236 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.? HI-236 inhibits HIV activity (wild type HTLV_IIB IC₅₀p24 < 0.001 μM) .

HY-P99140

Anti-Mouse IL-1R Antibody (JAMA-147)	Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Anti-Mouse IL-1R Antibody (JAMA-147) is an anti-mouse IL-1R IgG2b antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IL-1R Antibody (JAMA-147) diminishes Spp1hi-TAM-mediated T cell suppression. Anti-Mouse IL-1R Antibody (JAMA-147) can be used for the researches of inflammation, metabolic disease and infection, such as diabetes .

HY-146261

HI5	Microtubule/Tubulin Indoleamine 2,3-Dioxygenase (IDO) Apoptosis	Cancer
HI5 is a potent tublin and IDO inhibitor, with an IC₅₀ value of 70 nM in HeLa cells. HI5 inhibit IDO expression and decrease kynurenine production, leading to stimulating T cells activation and proliferation. HI5 can inhibit tubulin polymerization and cell migration, cause G2/M phase arrest, and induce apoptosis via the mitochondrial dependent apoptosis pathway and cause reactive oxidative stress generation in HeLa cells. HI5 can be used for researching anticancer .

HY-126900

HI-253	HIV Reverse Transcriptase	Others
HI-253 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase that has demonstrated greater activity than multiple anti-HIV compounds against both resistant and sensitive HIV-1 strains.

HY-175473

HI042	FLT3 Apoptosis	Cancer
HI042 is a FMS-like Tyrosine Kinase 3 (FLT3) inhibitor. HI042 shows IC₅₀ values of 0.62 μM for MOLM-13, 0.33 μM for MV4-11, and 0.89 μM for OCI-AML3 cells. HI042 selectively reduces the viability of FLT3-internal tandem duplication (FLT3-\|TD) mutations-positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes the clonogenic potential. HI042 can be used for the research of acute myeloid leukemia (AML) .

HY-150669S

HI-P224-d6 hydrochloride	Isotope-Labeled Compounds	Others
HI-P224-d₆ (hydrochloride) is the deuterium labeled HI-P224 hydrochloride .

HY-119832

Setastine EGIS-2062 free acid; EGYT-2062 free acid	Histamine Receptor	Inflammation/Immunology
Setastine (EGIS-2062 (free acid); EGYT-2062 (free acid) is an orally effective, non-sedative and long acting anti-allergic agent. Setastine possesses potent histamine Hi-receptor blocking properties and can be used for allergies and rhinitis research ^[1]<.

HY-RS00519

AKAP4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AKAP4 Human Pre-designed siRNA Set A contains three designed siRNAs for AKAP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AKAP4 Human Pre-designed siRNA Set A AKAP4 Human Pre-designed siRNA Set A

HY-108930

HI-207	Reverse Transcriptase HIV	Infection
HI-207 is a non-nucleoside reverse transcriptase inhibitor. HI-207 has anti-HIV activity (PBMC/p24 inhibition assay: IC₅₀ = 0.27 μM). HI-207 can be used for HIV infection research .

HY-RS00066

ABCC8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ABCC8 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCC8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ABCC8 Human Pre-designed siRNA Set A ABCC8 Human Pre-designed siRNA Set A

HY-101550R

HI-TOPK-032 (Standard)	TOPK Reference Standards	Cancer
HI-TOPK-032 (Standard) is the analytical standard of HI-TOPK-032 (HY-101550). This product is intended for research and analytical applications. HI-TOPK-032 is a potent and specific TOPK inhibitor.

HY-106901B

Asoxime dimesylate HI-6 dimesylate	Cholinesterase (ChE) nAChR	Neurological Disease
Asoxime dimesylate (HI-6 dimesylate) is an orally active thiosemicarbazone-based antidote. Asoxime dimesylate is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dimesylate significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dimesylate is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dimesylate can serve as an effective immunomodulator, improving the immune effect of the nervous system .

Cat. No.	Product Name	Type

HY-D0219

Thymol blue Thymolsulphonephthalein	Fluorescent Dye
Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

Thymol blue

Thymolsulphonephthalein

Fluorescent Dye

Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99140

Anti-Mouse IL-1R Antibody (JAMA-147)	Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Anti-Mouse IL-1R Antibody (JAMA-147) is an anti-mouse IL-1R IgG2b antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IL-1R Antibody (JAMA-147) diminishes Spp1hi-TAM-mediated T cell suppression. Anti-Mouse IL-1R Antibody (JAMA-147) can be used for the researches of inflammation, metabolic disease and infection, such as diabetes .

Cat. No.	Product Name	Chemical Structure

HY-106901AS

Asoxime-d4 dichloride 1 Publications Verification
Asoxime-d₄ dichloride (HI-6-d₄) is the deuterium labeled Asoxime dichloride. Asoxime dichloride is an orally active thiosemicarbazone-based antidote. Asoxime dichloride is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dichloride significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dichloride is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dichloride can serve as an effective immunomodulator, improving the immune effect of the nervous system.

Asoxime-d4 dichloride

1 Publications Verification

Asoxime-d₄ dichloride (HI-6-d₄) is the deuterium labeled Asoxime dichloride. Asoxime dichloride is an orally active thiosemicarbazone-based antidote. Asoxime dichloride is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dichloride significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dichloride is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dichloride can serve as an effective immunomodulator, improving the immune effect of the nervous system.

HY-150669S

HI-P224-d6 hydrochloride
HI-P224-d₆ (hydrochloride) is the deuterium labeled HI-P224 hydrochloride .

Host:	Mouse (2) Rabbit (4)
Reactivity:	Human (6) Rat (3) Mouse (3)
Application:	IHC-P (1) ICC/IF (3) IP (3) WB (6) ELISA (1)
Isotype:	IgG (4) IgG2b (2)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86301

	SESN2 Antibody (YA5993) Sestrin-2; HI95;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	SESN2 Antibody (YA5993) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SESN2.

HY-P82189

	SESN2 Antibody (YA1934) HI95; SES2; SEST2	WB, ICC/IF, IP	Human, Mouse, Rat
	SESN2 Antibody (YA1934) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SESN2.

HY-P82189A

	SESN2 Antibody (YA1934)(PBS only) HI95; SES2; SEST2	WB, ICC/IF, IP	Human, Mouse, Rat
	SESN2 Antibody (YA1934) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SESN2.

HY-P83624

	AMBP Antibody (YA3369) A1M; alpha 1 microglobulin bikunin; Alpha 1 microglycoprotein; AMBP; Bikunin; EDC1; HI30	WB, IHC-P	Human
	AMBP Antibody (YA3369) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMBP.

HY-P80874

	PRMT1 Antibody (YA686) ANM 1; ANM1; ANM1_HUMAN; complete cds; HCP 1; HCP1; Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like2; HI	WB	Human
	PRMT1 Antibody (YA686) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PRMT1.

HY-P80874A

	PRMT1 Antibody (YA686)(PBS only) ANM 1; ANM1; ANM1_HUMAN; complete cds; HCP 1; HCP1; Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like2; HI	WB	Human
	PRMT1 Antibody (YA686) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PRMT1.

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Cat. No.	Product Name		Classification

HY-RS00519

AKAP4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
AKAP4 Human Pre-designed siRNA Set A contains three designed siRNAs for AKAP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00066

ABCC8 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ABCC8 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCC8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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HI

Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

Isotope-Labeled Compounds

Antibodies

Oligonucleotides