149486-68-0
Chemical Structure
HI-346
- CAS No.: 149486-68-0
- Formula:C14H18BrN3S
- Molecular Weight:340.28
IUPAC Name: 1-(5-bromopyridin-2-yl)-3-(2-(cyclohex-1-en-1-yl)ethyl)thiourea
InChIKey: DMUWBIHBABUYBI-UHFFFAOYSA-N
SMILES: BrC1=CC=C(NC(NCCC2=CCCCC2)=S)N=C1
Biological Activity: HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC50 value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC50 value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research[1].
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HI-346 | HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC50 value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC50 value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research. | |||||||||||||||||||||
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Keywords
