HI042
HI042 is a FMS-like Tyrosine Kinase 3 (FLT3) inhibitor. HI042 shows IC50 values of 0.62 μM for MOLM-13, 0.33 μM for MV4-11, and 0.89 μM for OCI-AML3 cells. HI042 selectively reduces the viability of FLT3-internal tandem duplication (FLT3-|TD) mutations-positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes the clonogenic potential. HI042 can be used for the research of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- CAS No.: 898168-15-5
- Formula: C14H11N3O3S
- Molecular Weight:301.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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FLT3 |
HI042 shows IC50 values for MOLM-13 cells were 0.88, 0.52, and 0.36 μM and >40, 1.03, and 0.64 μM for MV4-11 cells for the periods of 24, 48, and 72 h, respectively[1].
HI042 (0.3-5 μM, 7-10 days) reduces autonomous clonal growth in MOLM-13 and MV4-11 cells[1].
HI042 (0.25-4 μM, 72 h) induces cell apoptosis and disrupts in MOLM-13 and MV4-11 cells[1].
HI042 (0.25-1 μM, 72 h) induces cell differentiation in MOLM-13 and MV4-11 cells[1].
HI042 (0.06-1 μM, 72 h) significantly reduces the viability companied with Quizartinib (HY-13001) (0.12-2 nM) in MOLM-13 and MV4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLM-13 and MV4-11 cells
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Concentration:0.312, 0.625, 1.25, 2.5, 5, 10, 20, and 40 μM
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Incubation Time:24, 48 and 72 h
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Result:Reduced cell viability in a time- and concentration dependent manner.
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Cell Line:MOLM-13 and MV4-11 cells
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Concentration:0.25, 0.5 1, 2 and 4 μM
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Incubation Time:72 h
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Result:Increased the SubG1 cell population.
Increased PARP1 cleavage and γH2AX expression.
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Cell Line:MOLM-13 and MV4-11 cells
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Concentration:0.25, 0.5 and 1 μM
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Incubation Time:72 h
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Result:Increased CD11b-positive cells.
Increased expression of the genes CEBPA and CEBPB.
Chemical Information
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CAS No. 898168-15-5
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Molecular Weight 301.32
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Formula C14H11N3O3S
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SMILES
O=C(N/N=C/C1=CC=C([N+]([O-])=O)S1)/C=C/C2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HI042 Related Classifications
HY-175473 Related Classifications
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