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Results for "

HIV-1 latency

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (24) Apoptosis (6) Autophagy (4) Bacterial (2) CDK (2) Drug Derivative (1) Epigenetic Reader Domain (4) HDAC (5) IAP (1) Isotope-Labeled Compounds (1) Ligands for E3 Ligase (1) NF-κB (2) PKC (2) PROTACs (1) Proteasome (2) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (6) Infection (20) Inflammation/Immunology (3) Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds

Targets Recommended: HIV Integrase HIV HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10224

Panobinostat Maximum Cited Publications 83 Publications Verification LBH589; NVP-LBH589	HDAC Autophagy HIV Apoptosis	Cancer
Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities . Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells . Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma .

HY-13207

ONX-0914 20+ Cited Publications PR-957	Proteasome Bacterial HIV	Infection Inflammation/Immunology
ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .

HY-114268

BRD-K98645985 3 Publications Verification	HIV	Infection
BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC₅₀ of ~2.37 μM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses *HIV-1* latency, without T cell activation or toxicity .

HY-19618

BRD3308 1 Publications Verification	HDAC HIV Apoptosis	Infection Metabolic Disease
BRD3308 is a highly selective HDAC3 inhibitor with an IC₅₀ of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC₅₀ of 1.26 μM) or HDAC2 (IC₅₀ of 1.34 μM). BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates *HIV-1* transcription and disrupts *HIV-1* latency .

HY-15815

Bromosporine 5 Publications Verification	Epigenetic Reader Domain Apoptosis CDK HIV	Cancer
Bromosporine, a chemical probe, is a potent BET inhibitor with an IC₅₀ value of 2.1 μM for PCAF. Bromosporine can arrest cell cycle and induce apoptosis in cancer cells. Bromosporine exhibits excellent antitumor activity in xenograft mice model when combined with 5-Fluorouracil (HY-90006). Bromosporine can increase CDK9 T-loop phosphorylation in *HIV-1* latency models, resulting the protection of reactivate HIV-1 replication from latency. Bromosporine can be used to research colorectal cancer, acute myeloid leukemia (AML) and AIDS .

HY-A0068

Aurothioglucose 2 Publications Verification Gold thioglucose	NF-κB HIV Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .

HY-130514

SMAPP1	HIV CDK	Infection
SMAPP1 is an activator of protein phosphatase-1 (PP1). SMAPP1 increases phosphorylation of CDK9’s Ser90 and Thr186 residues, but not Ser175. SMAPP1 induces HIV-1 replication, upregulates HIV-1 transcription that led to the reactivation of latent HIV-1 provirus .

HY-10224R

Panobinostat (Standard) 80+ Cited Publications LBH589 (Standard); NVP-LBH589 (Standard)	Reference Standards HDAC Autophagy HIV Apoptosis	Infection Cancer
Panobinostat (Standard) (LBH589 (Standard)) is the analytical standard of Panobinostat (HY-10224). This product is intended for research and analytical applications. Panobinostat is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities . Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells . Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma .

HY-13207A

ONX-0914 TFA 20+ Cited Publications PR-957 TFA	Proteasome Bacterial HIV	Infection Inflammation/Immunology
ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .

HY-10224S

Panobinostat-d4 LBH589-d₄; NVP-LBH589-d₄	HDAC Autophagy HIV Apoptosis	Cancer
Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-10224S1

Panobinostat-d4 hydrochloride LBH589-d4 hydrochloride; NVP-LBH589-d4 hydrochloride	Isotope-Labeled Compounds HDAC Autophagy HIV Apoptosis	Cancer
Panobinostat-d₄ (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-163666

HIV-1 inhibitor-68	HIV PKC	Infection
HIV-1 inhibitor-68 (compound 26) is a protein kinase C (PKC) activator derivative with reversal activity in *HIV-1* latency. HIV-1 inhibitor-68 may be able to eliminate cells latently infected with *HIV-1*, .

HY-162077

HIV-IN-10	HIV	Infection
HIV-IN-10 is a *HIV-1 latency* reversing agent .

HY-147553

HIV-1 inhibitor-36	HIV	Infection
HIV-1 inhibitor-36 (Compound 2) is a potent *HIV-1. HIV-1* inhibitor-36 has the potential for further development as novel latency reversing agents .

HY-147555

HIV-1 inhibitor-38	HIV	Infection
HIV-1 inhibitor-38 (Compound 91) is a potent *HIV-1. HIV-1* inhibitor-38 has the potential for further development as novel latency reversing agents .

HY-147554

HIV-1 inhibitor-37	HIV	Infection
HIV-1 inhibitor-37 (Compound 83) is a potent *HIV-1. HIV-1* inhibitor-37 has the potential for further development as novel latency reversing agents .

HY-155599

HIV-1 protease-IN-10	HIV PKC	Infection
HIV-1 protease-IN-10 (Compound 2) has *HIV-1* latency reversing activity (IC₅₀: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC₅₀: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis .

HY-119490

UMB-136	Epigenetic Reader Domain HIV	Infection
UMB-136 is a bromodomain inhibitor. UMB-136 is a promising latency-reversing agent (LRA) for *HIV-1* eradication. UMB-136 reactivates HIV-1 in multiple cell models. UMB-136 enhances HIV-1 transcription and increases viral production through the release of P-TEFb .

HY-147552

HIV-1 inhibitor-35	HIV	Infection
HIV-1 inhibitor-35 (compound 74) is a potent *HIV-1* inhibitor with EC₅₀s of 80 nM and 70 nM for LTR and CMV in HEK293 cells, respectively. HIV-1 inhibitor-35 has inhibitory activity against liver cancer cell HepG2 with a CC₅₀ of 40 nM. HIV-1 inhibitor-35 can be used as HIV-1 latency reversing agent .

HY-134844

Ciapavir SBI-0953294	HIV IAP NF-κB	Infection
Ciapavir (SBI-0953294) is a *HIV-1* latency-reversing agent. Ciapavir reverses latent HIV-1 reservoir in vitro and in vivo without inducing systemic T cell activation or broad cytokine release. Ciapavir degrades cIAP1 and activates non-canonical NF-κB pathway. Ciapavir can be used for the research of HIV-1 infection .

HY-181841

TLR8 agonist 10	Toll-like Receptor (TLR) HIV	Infection
TLR8 agonist 10 is a selective TLR8 agonist with an EC₅₀ of 0.019 μM in humans. TLR8 agonist 10 activates TLR8-mediated signaling pathways. As a latency-reversing agent, TLR8 agonist 10 reactivates latent *HIV-1* reservoirs. TLR8 agonist 10 activates innate cytotoxic natural killer cells to target HIV-infected CD4 ⁺ T cells. TLR8 agonist 10 is applicable to research related to HIV-1 infection .

HY-181831

XQ2	Drug Derivative HIV Epigenetic Reader Domain	Infection
XQ2 is a resveratrol (HY-16561) derivative and latency-reversing agent. XQ2 releases positive transcription elongation factor b (P-TEFb) from BRD4, thereby promoting Tat-dependent viral transcription. XQ2 reactivates latent *HIV-1* via activating P-TEFb .

HY-181164

PROTAC BRD4 Degrader-43	PROTACs Epigenetic Reader Domain HIV	Infection
PROTAC BRD4 Degrader-43 is a BRD4 PROTAC degrader. PROTAC BRD4 Degrader-43 recruits the DCAF1-DDB1-Cul4A E3 ligase complex via a Vpr-derived peptide moiety to induce BRD4 ubiquitination and degradation through the ubiquitin-proteasome system. PROTAC BRD4 Degrader-43 exhibits potent HIV latency-reversing activity. PROTAC BRD4 Degrader-43 can be used for the research of HIV-1 latent infection . (Pink: BRD4 ligand (HY-13030); Blue: Cul4A-DDB1-DCAF1 ligand (HY-P11640); Black: conjugate of PEG linker + cell-penetrating peptide (HY-P2483))

HY-P11640

Vpr (1-14)	Ligands for E3 Ligase HIV	Infection
Vpr (1-14) is a viral protein R and acts as an accessory protein of HIV-1. Vpr (1-14) can binds to Cul4A-DDB1-DCAF1 E3 ligase complex and can be used as an E3 ligase-binding component in PROTACs. Vpr (1-14) can be used to synthesize PROTAC BRD4 Degrader-43 (HY-181164) .

Cat. No.	Product Name	Target	Research Area

HY-P11640

Vpr (1-14)	Ligands for E3 Ligase HIV	Infection
Vpr (1-14) is a viral protein R and acts as an accessory protein of HIV-1. Vpr (1-14) can binds to Cul4A-DDB1-DCAF1 E3 ligase complex and can be used as an E3 ligase-binding component in PROTACs. Vpr (1-14) can be used to synthesize PROTAC BRD4 Degrader-43 (HY-181164) .

Cat. No.	Product Name	Chemical Structure

HY-10224S

Panobinostat-d4
Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

Panobinostat-d4

Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-10224S1

Panobinostat-d4 hydrochloride
Panobinostat-d₄ (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

Panobinostat-d4 hydrochloride

Panobinostat-d₄ (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

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