2416971-32-7
2416971-32-7
Chemical Structure
HIV-1 inhibitor-35
- CAS No.: 2416971-32-7
- Formula:C13H12Cl3N5OS
- Molecular Weight:392.69
IUPAC Name: N-(5-chlorothiazol-2-yl)-4-(5,6-dichloropyridin-3-yl)piperazine-1-carboxamide
InChIKey: RBHIWEJLJQXJSA-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC1)C2=CN=C(C(Cl)=C2)Cl)NC3=NC=C(S3)Cl
Biological Activity: HIV-1 inhibitor-35 (compound 74) is a potent HIV-1 inhibitor with EC50s of 80 nM and 70 nM for LTR and CMV in HEK293 cells, respectively. HIV-1 inhibitor-35 has inhibitory activity against liver cancer cell HepG2 with a CC50 of 40 nM. HIV-1 inhibitor-35 can be used as HIV-1 latency reversing agent[1].
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HIV-1 inhibitor-35 | HIV-1 inhibitor-35 (compound 74) is a potent HIV-1 inhibitor with EC50s of 80 nM and 70 nM for LTR and CMV in HEK293 cells, respectively. HIV-1 inhibitor-35 has inhibitory activity against liver cancer cell HepG2 with a CC50 of 40 nM. HIV-1 inhibitor-35 can be used as HIV-1 latency reversing agent. | |||||||||||||||||||||
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References
Keywords
